| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 9.9% | $18,525,720 | 2,470,096 | Vestal Point Capital, LP | 30 Sep 2024 | |||
| Ikarian Capital, LLC | 16% | -27% | $6,473,244 | 967,600 | 0% | Ikarian Capital, LLC | 30 Nov 2025 | |
| JANUS HENDERSON GROUP PLC | 10% | +150% | $4,172,774 | +$3,057,778 | 623,733 | +274% | JANUS HENDERSON GROUP PLC | 28 Nov 2025 |
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | $4,147,275 | 552,970 | Venrock Healthcare Capital Partners III, L.P. | 30 Sep 2025 | |||
| Lind Global Fund II LP | 8.8% | $3,318,600 | 442,480 | Lind Global Fund II LP | 30 Sep 2025 | |||
| PERCEPTIVE ADVISORS LLC | 7% | $4,158,675 | 439,142 | Perceptive Advisors LLC | 18 Dec 2025 | |||
| Invus Global Management, LLC | 9.4% | $2,562,846 | 427,141 | Raymond Debbane | 26 Sep 2025 | |||
| RTW INVESTMENTS, LP | 10% | $2,460,427 | 418,440 | RTW Investments, LP | 31 Mar 2025 | |||
| Dellora Investments LP | 8.8% | -15% | $2,064,297 | +$739,528 | 351,071 | 0% | Dellora Investments LP | 05 Mar 2025 |
| Point72 Asset Management, L.P. | 7.4% | $2,037,798 | 339,633 | Point72 Asset Management, L.P. | 22 Oct 2025 | |||
| INTEGRATED CORE STRATEGIES (US) LLC | 6.9% | +22% | $1,882,272 | +$480,576 | 313,712 | +34% | Integrated Core Strategies (US) LLC | 30 Sep 2025 |
| S.H.N. Financial Investments Ltd. | 5% | $1,052,814 | 179,050 | S.H.N. Financial Investments Ltd. | 31 Dec 2024 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Ikarian Capital, LLC | 15% | 967,600 | 1.7% | $7,363,436 | |
| VR ADVISER, LLC | 7% | 437,708 | +344% | 0.19% | $3,330,958 |
| RTW INVESTMENTS, LP | 6% | 378,346 | 0% | 0.04% | $2,879,213 |
| Siren, L.L.C. | 5.6% | 352,441 | 0.1% | $2,682,076 | |
| BOOTHBAY FUND MANAGEMENT, LLC | 5.6% | 352,206 | 0.07% | $2,680,288 | |
| BVF INC/IL | 5.4% | 339,549 | 0% | 0.1% | $2,583,968 |
| MILLENNIUM MANAGEMENT LLC | 5% | 313,712 | +34% | 0% | $2,387,348 |
| Vivo Capital, LLC | 3.3% | 208,333 | 0% | 0.13% | $1,585,414 |
| MORGAN STANLEY | 2.8% | 178,329 | +0.18% | 0% | $1,357,084 |
| MARSHALL WACE, LLP | 2.8% | 177,209 | 0% | $1,348,560 | |
| Integral Health Asset Management, LLC | 2.7% | 167,000 | 0% | 0.09% | $1,270,870 |
| JANUS HENDERSON GROUP PLC | 2.7% | 166,666 | 0% | 0% | $1,273,328 |
| VANGUARD GROUP INC | 2.6% | 161,800 | +626% | 0% | $1,231,298 |
| Woodline Partners LP | 1.4% | 88,211 | 0% | $671,286 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.3% | 83,333 | 0% | 0% | $634,164 |
| Velan Capital Investment Management LP | 1.3% | 83,333 | 0% | 0.6% | $634,164 |
| RENAISSANCE TECHNOLOGIES LLC | 0.9% | 56,600 | 0% | $430,726 | |
| Vestal Point Capital, LP | 0.85% | 53,439 | 0% | 0.02% | $406,671 |
| ADAR1 Capital Management, LLC | 0.85% | 53,428 | -66% | 0.04% | $406,587 |
| CITADEL ADVISORS LLC | 0.69% | 43,253 | +318% | 0% | $329,156 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.55% | 34,425 | +0.55% | 0% | $261,974 |
| Virtu Financial LLC | 0.19% | 12,119 | 0.01% | $92,000 | |
| DRW Securities, LLC | 0.17% | 10,514 | 0% | $80,011 | |
| Tower Research Capital LLC (TRC) | 0.01% | 501 | -60% | 0% | $3,813 |
| BlackRock, Inc. | 0% | 301 | +0.33% | 0% | $2,291 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (% of par) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 1 | $9 | 900% | 1 | |
| 2025 Q3 | 4,720,738 | $35,929,590 | +$18,970,343 | 761% | 34 |
| 2025 Q2 | 2,231,961 | $12,926,914 | +$1,314,380 | 576% | 25 |
| 2025 Q1 | 2,006,422 | $13,111,231 | +$4,224,591 | 655% | 23 |
| 2024 Q4 | 1,362,190 | $8,426,122 | +$1,144,778 | 619% | 21 |
| 2024 Q3 | 1,228,920 | $4,253,022 | +$4,189,827 | 346% | 19 |
| 2024 Q2 | 18,829 | $57,207 | +$35,228 | 301.5% | 10 |
| 2024 Q1 | 7,235 | $30,532 | +$30,532 | 423.99% | 9 |