| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 18.9% | +69.1% | $103,327,531 | +$46,529,346 | 7,745,692 | +81.9% | Baker Bros. Advisors LP | 01 Aug 2025 |
| Sullivan Brian F. | 9.1% | $198,252,228 | 4,013,203 | Brian F. Sullivan | 30 Sep 2025 | |||
| Soleus Capital Master Fund, L.P. | 9.9% | $42,748,911 | 3,872,184 | Soleus Capital Master Fund, L.P. | 31 Dec 2024 | |||
| Growth Equity Opportunities 18 VGE, LLC | 8.1% | $142,483,108 | 3,535,561 | Growth Equity Opportunities 18 VGE, LLC | 14 Aug 2025 | |||
| PERCEPTIVE ADVISORS LLC | 6.55% | +56% | $35,625,764 | +$13,838,769 | 2,670,597 | +63.5% | Perceptive Advisors LLC | 30 Jul 2025 |
| BlackRock, Inc. | 5.9% | $24,056,867 | 2,179,064 | BlackRock, Inc. | 31 Dec 2024 | |||
| Laing Lance G. | 3.6% | $77,497,040 | 1,568,766 | Lance G. Laing | 30 Sep 2025 | |||
| COMMODORE CAPITAL LP | 2.9% | $12,095,976 | 1,095,650 | COMMODORE CAPITAL LP | 31 Dec 2024 | |||
| BIOTECHNOLOGY VALUE FUND L P | 1.6% | $32,525,997 | 658,421 | BVF PARTNERS L P/IL | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 39,074,393 | $1,930,231,066 | +$426,141,076 | $49.4 | 175 |
| 2025 Q2 | 31,673,216 | $422,835,620 | +$15,733,373 | $13.35 | 96 |
| 2025 Q1 | 30,900,170 | $312,487,179 | +$898,666 | $10.11 | 93 |
| 2024 Q4 | 30,331,206 | $397,021,776 | -$1,092,989 | $13.09 | 101 |
| 2024 Q3 | 29,969,744 | $446,851,829 | +$2,686,502 | $14.91 | 103 |
| 2024 Q2 | 29,307,857 | $480,064,541 | +$111,720,486 | $16.38 | 90 |
| 2024 Q1 | 22,076,655 | $476,856,986 | +$132,629,386 | $21.6 | 77 |
| 2023 Q4 | 15,958,101 | $232,511,640 | +$16,970,910 | $14.57 | 59 |
| 2023 Q3 | 14,109,550 | $128,962,621 | +$12,312,187 | $9.14 | 55 |
| 2023 Q2 | 13,990,031 | $152,609,568 | +$20,838,872 | $10.98 | 55 |
| 2023 Q1 | 12,092,759 | $123,950,456 | +$9,073,876 | $10.25 | 41 |
| 2022 Q4 | 11,188,481 | $156,752,383 | +$89,861,266 | $14.01 | 38 |
| 2022 Q3 | 4,800,325 | $48,193,566 | +$8,790,870 | $10.04 | 29 |
| 2022 Q2 | 4,674,423 | $42,534,327 | -$5,316,020 | $9.1 | 35 |
| 2022 Q1 | 4,534,183 | $42,373,387 | -$3,150,211 | $9.35 | 51 |
| 2021 Q4 | 5,410,201 | $71,337,002 | -$4,744,047 | $13.19 | 53 |
| 2021 Q3 | 5,688,763 | $102,442,012 | -$21,097,032 | $18 | 61 |
| 2021 Q2 | 6,482,071 | $155,605,368 | +$79,414,255 | $24 | 65 |
| 2021 Q1 | 3,218,175 | $46,148,778 | +$18,398,118 | $14.34 | 37 |
| 2020 Q4 | 1,936,080 | $17,740,302 | -$64,895 | $9.17 | 26 |
| 2020 Q3 | 1,909,259 | $11,076,569 | -$1,171,713 | $5.8 | 27 |
| 2020 Q2 | 2,078,883 | $14,400,479 | -$1,166,257 | $6.93 | 33 |
| 2020 Q1 | 2,259,210 | $14,682,895 | +$6,912 | $6.5 | 41 |
| 2019 Q4 | 2,233,025 | $23,758,098 | -$564,921 | $10.64 | 45 |
| 2019 Q3 | 2,272,720 | $38,590,454 | -$477,368 | $16.98 | 45 |
| 2019 Q2 | 2,297,887 | $57,435,925 | +$1,230,639 | $25 | 45 |
| 2019 Q1 | 2,249,537 | $49,281,125 | +$252,022 | $21.9 | 45 |
| 2018 Q4 | 2,236,812 | $53,661,216 | +$16,387,100 | $23.99 | 43 |
| 2018 Q3 | 1,548,234 | $44,530,761 | +$3,262,151 | $28.77 | 45 |
| 2018 Q2 | 1,445,918 | $35,886,504 | +$5,066,356 | $24.82 | 46 |
| 2018 Q1 | 1,333,984 | $21,980,256 | -$967,034 | $16.48 | 37 |
| 2017 Q4 | 1,389,537 | $26,331,138 | +$1,178,926 | $18.95 | 38 |
| 2017 Q3 | 1,336,534 | $16,359,000 | +$16,359,000 | $12.24 | 16 |