MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2018 to Q4 2025

Type / Class: Equity / Ordinary Shares, nominal value $0.00003881 per share
Symbol: MGTX on Nasdaq
Shares outstanding: 80,942,341
Price per share: $7.95
All holders as of 30 Sep 2025: Q3 2025
Total 13F shares: 64,091,394
Total reported value: $527,366,098
% of total 13F portfolios: 0%
Share change: -162,182
Value change: +$100,848
Number of holders: 121
Price from insider filings: $7.95

Reported Shares, Excluding Options vs Price

Reported Value, Excluding Options

Total Investors

Significant Owners of MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX) based on Schedule 13D/G filings

Filer	Ownership	Holdings Value	Nb Shares	Reporting Name	Report Period
PERCEPTIVE ADVISORS LLC	13%	$85,934,055	10,441,562	Perceptive Advisors LLC	31 Dec 2025
Prosight Management, LP	5.4%	$29,189,026	4,356,571	W. Lawrence Hawkins	31 Mar 2025
Adage Capital Management, L.P.	5.2%	$34,439,077	4,184,578	Adage Capital Management, L.P.	30 Sep 2025

As of 30 Sep 2025, 121 institutional investors reported holding 64,091,394 shares of MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX). This represents 79% of the company’s total 80,942,341 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX) together control 75% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution	Ownership %	Shares Held	Share Change %	Portfolio %	Holdings Value
PERCEPTIVE ADVISORS LLC	16%	12,626,103	0%	3%	$103,792,540
Sanofi	15%	12,197,737	0%	39%	$100,387,376
JOHNSON & JOHNSON	8.2%	6,641,064	0%	11%	$54,655,957
ADAGE CAPITAL PARTNERS GP, L.L.C.	5.2%	4,184,578	-31%	0.05%	$34,439,077
Prosight Management, LP	5.1%	4,089,509	-11%	8.1%	$33,656,659
Rubric Capital Management LP	4.6%	3,726,451	0%	0.41%	$30,668,692
BlackRock, Inc.	3.4%	2,774,272	-3.1%	0%	$22,832,257
683 Capital Management, LLC	3.2%	2,625,000	-2.4%	2%	$21,603,749
MILLENNIUM MANAGEMENT LLC	3.2%	2,560,969	+226%	0.02%	$21,076,775
J. Goldman & Co LP	2.2%	1,800,931	-12%	0.56%	$14,821,662
Knoll Capital Management, LLC	1.5%	1,250,000	0%	5.5%	$10,287,500
MORGAN STANLEY	1.5%	1,241,994	+173%	0%	$10,221,611
Erste Asset Management GmbH	0.88%	709,702	-10%	0.06%	$5,855,042
STATE STREET CORP	0.84%	681,031	-0.17%	0%	$5,604,885
22NW, LP	0.72%	586,519	0%	2.5%	$4,827,051
GEODE CAPITAL MANAGEMENT, LLC	0.69%	555,313	-0.4%	0%	$4,570,225
Long Focus Capital Management, LLC	0.65%	524,745	0%	0.25%	$4,318,651
VANGUARD GROUP INC	0.57%	463,935	+10%	0%	$3,818,185
ROYAL BANK OF CANADA	0.37%	300,343	-1.2%	0%	$2,471,000
NORTHERN TRUST CORP	0.33%	270,893	-1.1%	0%	$2,229,450
GOLDMAN SACHS GROUP INC	0.32%	260,219	+78%	0%	$2,141,602
CITADEL ADVISORS LLC	0.25%	204,865	+1.6%	0%	$1,686,039
Woodline Partners LP	0.25%	200,323		0.01%	$1,648,658
BANK OF AMERICA CORP /DE/	0.24%	198,206	-26%	0%	$1,631,235
D. E. Shaw & Co., Inc.	0.21%	173,202		0%	$1,425,453

Institutional Holders of MeiraGTx Holdings plc - Ordinary Shares, nominal value $0.00003881 per share (MGTX) across Reporting Periods

Period	Reported Shares, Excl. Options	Value, Excl. Options	Value Change	Puts Notional Value	Calls Notional Value	Price (Median)	Investors
2025 Q4	417,868	$3,322,313	+$1,703,741			$7.95	8
2025 Q3	64,091,394	$527,366,098	+$100,848	$511,083	$476,517	$8.23	121
2025 Q2	64,273,449	$419,562,716	+$27,529,421	$88,672	$237,980	$6.52	111
2025 Q1	59,986,380	$406,655,139	+$13,171,914	$260,352	$1,078,020	$6.78	118
2024 Q4	58,134,853	$353,880,152	+$5,661,044	$187,572	$1,657,698	$6.09	101
2024 Q3	45,221,185	$188,552,401	+$19,157,134	$129,270	$80,064	$4.17	97
2024 Q2	40,458,048	$170,235,110	+$4,338,640	$129,247	$101,882	$4.21	91
2024 Q1	39,300,324	$238,469,096	+$641,712	$126,863	$20,031	$6.07	95
2023 Q4	39,193,056	$275,136,034	+$9,570,624	$954,720	$483,658	$7.02	86
2023 Q3	37,791,917	$185,560,138	+$956,121	$137,971	$70,213	$4.91	74
2023 Q2	37,549,331	$252,327,936	+$61,583,237	$198,912	$61,152	$6.72	77
2023 Q1	28,748,444	$148,619,405	-$5,267,767	$91,509	$133,386	$5.17	88
2022 Q4	29,625,998	$193,116,514	+$5,062,552	$279,708	$459,660	$6.52	98
2022 Q3	27,968,146	$234,567,872	-$9,091,785	$645,000	$409,000	$8.41	98
2022 Q2	28,548,680	$216,121,658	-$5,764,085	$182,000	$268,000	$7.57	105
2022 Q1	29,291,750	$405,685,931	+$11,811,095	$386,000	$323,000	$13.85	101
2021 Q4	28,368,763	$672,844,608	+$17,527,958	$1,593,000	$1,373,000	$23.74	95
2021 Q3	27,863,121	$367,263,288	-$1,783,285	$217,000	$0	$13.18	79
2021 Q2	27,969,634	$433,466,019	+$13,341,762	$200,000	$172,000	$15.50	76
2021 Q1	27,129,412	$384,781,966	+$5,393,087	$182,000	$186,000	$14.43	79
2020 Q4	26,738,368	$404,815,585	+$66,577,970			$15.14	90
2020 Q3	22,138,540	$293,123,916	+$16,367,005			$13.24	82
2020 Q2	20,907,650	$261,758,875	+$10,066,092			$12.52	78
2020 Q1	20,093,813	$270,060,598	+$42,993,852			$13.44	82
2019 Q4	16,682,969	$333,992,017	+$16,114,615			$20.02	85
2019 Q3	15,884,005	$253,345,768	+$49,225,801			$15.95	81
2019 Q2	12,692,608	$334,563,403	+$25,170,435			$26.88	68
2019 Q1	11,974,218	$205,287,171	+$83,916,121			$17.23	54
2018 Q4	7,221,365	$69,612,048	+$7,485,483			$9.64	37
2018 Q3	6,408,742	$87,153,000	-$155,481			$13.60	35
2018 Q2	6,512,433	$74,625,000	+$74,625,013			$11.46	23