Security key
00773J202
Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (SYRE)
CUSIP: 00773J202
Q3 2025 13F Holders as of 30 Sep 2025
- Security type / class
- Equity / Common Stock, $0.0001 Par Value Per Share
- Shares outstanding
- 86,389,920
- Total 13F shares
- 64,298,657
- Share change
- +600,718
- Total reported value
- $1,077,601,900
- Put/Call ratio
- 59%
- Reported price per share
- $16.76
- Number of holders
- 136
- Value change
- +$12,200,602
- Number of buys
- 64
- Number of sells
- 56
Security identity
Holder snapshot
Report period
Q3 2025
Institutions
136
Top holders
10
SYRE full security history
Ownership snapshot
Full 13F holder table
Newer quarter: Q4 2025
Previous quarter: Q2 2025
Spyre Therapeutics, Inc. SEC filings
Spyre Therapeutics, Inc. company facts
Broader feeds
Reporting periods
Holder history for CUSIP 00773J202
Recent filing periods:
Ownership snapshot
Top shareholders of SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Lead holder
BlackRock, Inc.
13D/G signal
BlackRock, Inc.
Evidence rows
50
Latest as of
30 Jun 2025
13F
13D/G
3/4/5
Lead comparable stake: 6.6%
13D/G row: BlackRock, Inc.
Showing first 8 of 50 holder rows.
Open remaining rows
Rank 1 holder
BlackRock, Inc.
13F
13D/G
- Ownership
- 6.6%
- Position
- $59.99M
Rank 2 holder
RTW INVESTMENTS, LP
13D/G
13F
- Ownership
- 6.2%
- Position
- $54.4M
Rank 3 holder
Venrock Healthcare Capital Partners III, L.P.
13D/G
- Ownership
- 4.6%
- Position
- $40.34M
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| BlackRock, Inc. |
13F
13D/G
Company
|
6.6%
from 13D/G
|
$59,989,221
4,007,296 shares
|
— | 30 Jun 2025 |
| RTW INVESTMENTS, LP |
13D/G
13F
Company
|
6.2%
|
$54,402,380
3,621,996 shares
|
$0 | 31 Dec 2024 |
| Venrock Healthcare Capital Partners III, L.P. |
13D/G
|
4.6%
|
$40,335,429
2,685,448 shares
|
$0 | 31 Dec 2024 |
| FMR LLC |
13F
Company
|
10%
|
$135,523,919
9,053,034 shares
|
— | 30 Jun 2025 |
| Fairmount Funds Management LLC |
13F
Company
|
4.7%
|
$60,150,972
4,018,101 shares
|
— | 30 Jun 2025 |
| TANG CAPITAL MANAGEMENT LLC |
13F
Company
|
3.7%
|
$47,904,000
3,200,000 shares
|
— | 30 Jun 2025 |
| VANGUARD GROUP INC |
13F
Company
|
3.5%
|
$45,906,793
3,066,586 shares
|
— | 30 Jun 2025 |
| Venrock Adviser, LLC |
13F
Company
|
3.1%
|
$40,201,157
2,685,448 shares
|
— | 30 Jun 2025 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
13F holder rows
Institutional holders as of Q3 2025
Investor-level positions for this CUSIP, loaded as an interactive table.
Institutions
136
Shares
64,298,657
Rows loaded
136
| Investor | Option | Weight % | Change % | Reported value | * Price | Shares | Share Change | Activity | Report Period |
|---|
* Reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that failed the local validity check.
Compare Q3 2025 vs Q2 2025 Across Filers
Q2 2025 holders
128
Q3 2025 holders
136
Holder diff
8
| Investor | Q2 2025 Shares | Q3 2025 Shares | Share Diff | Share Chg % | Q2 2025 value | Q3 2025 value | Value change | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend