Type / Class
Equity / Common Stock, $0.0001 par value
Shares outstanding
81,149,970
Total 13F shares
64,298,657
Share change
+600,744
Total reported value
$1,077,601,900
Put/Call ratio
59%
Price per share
$16.76
Number of holders
136
Value change
+$12,201,038
Number of buys
64
Number of sells
56

Institutional Holders of Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE) as of Q3 2025

As of 30 Sep 2025, Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE) was held by 136 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 64,298,657 shares. The largest 10 holders included FMR LLC, Fairmount Funds Management LLC, BlackRock, Inc., RTW INVESTMENTS, LP, TANG CAPITAL MANAGEMENT LLC, VANGUARD GROUP INC, VR ADVISER, LLC, BRAIDWELL LP, Capital International Investors, and Driehaus Capital Management LLC. This page lists 136 institutional shareholders reporting positions in this security for the Q3 2025 filing period.
Investor Option Weight % Change % Value $ * Price Shares Share Change Activity Report Period
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.