RTW INVESTMENTS, LP

Holdings History for Spyre Therapeutics, Inc. - Common Stock, par value $0.0001 per share (SYRE)

Symbol: SYRE on Nasdaq
Investment type: Equity / Common Stock, par value $0.0001 per share
Latest Disclosed Shares Owned: 3,621,996 shares
Security Ownership %: 6.2%

Shares, Excluding Options vs Price

Value, Excluding Options

RTW Investments, LP ownership in Spyre Therapeutics, Inc. Common Stock, par value $0.0001 per share (SYRE)

14 Feb 2025 - RTW Investments, LP has filed an SCHEDULE 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 3,621,996 shares of Spyre Therapeutics, Inc. Common Stock, par value $0.0001 per share (SYRE). This represents 6.2% ownership of the company. This is the first filing by RTW INVESTMENTS, LP disclosing ownership of Spyre Therapeutics, Inc. Common Stock, par value $0.0001 per share (SYRE).

Reporting Name	Ownership %	Change	Value $	Shares owned	Change	Activity %	Price	Form	Report date	Filing time
RTW Investments, LP	6.2%		$54,402,380	3,621,996			$15.02	13G/A	31 Dec 2024	14 Feb 2025, 09:00

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025	1.4%	+0.18%	$136,674,589	4,171,996	+550,000	+15%	$32.76	Q4 2025
30 Sep 2025	0.75%	0%	$60,704,653	3,621,996	0		$16.76	Q3 2025
30 Jun 2025	0.77%	0%	$54,221,280	3,621,996	0		$14.97	Q2 2025
31 Mar 2025	0.89%	0%	$58,440,905	3,621,996	0		$16.13	Q1 2025
31 Dec 2024	1.3%	+0.13%	$84,320,067	3,621,996	+363,636	+11%	$23.28	Q4 2024
30 Sep 2024	1.4%	0%	$95,828,368	3,258,360	0		$29.41	Q3 2024
30 Jun 2024	1.2%	+0.36%	$76,604,044	3,258,360	+1,025,600	+46%	$23.51	Q2 2024
31 Mar 2024	1.3%	0%	$84,688,586	2,232,760	0		$37.93	Q1 2024
31 Dec 2023	0.75%	+0.75%	$48,048,995	2,232,760	+2,232,760	NEW	$21.52	Q4 2023

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.