Security key
00773J202
Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (SYRE)
CUSIP: 00773J202
Q4 2024 13F Holders as of 31 Dec 2024
- Type / Class
- Equity / Common Stock, $0.0001 Par Value Per Share
- Shares outstanding
- 86,389,920
- Total 13F shares
- 59,883,954
- Share change
- +7,893,875
- Total reported value
- $1,394,038,124
- Put/Call ratio
- 49%
- Price per share
- $23.28
- Number of holders
- 129
- Value change
- +$171,655,898
- Number of buys
- 86
- Number of sells
- 41
Report period
Q4 2024
Institutions
129
Top holders
10
SYRE full security history
Newer quarter: Q1 2025
Previous quarter: Q3 2024
Spyre Therapeutics, Inc. SEC filings
Spyre Therapeutics, Inc. company facts
Broader feeds
Reporting periods
Holder history for CUSIP 00773J202
Recent filing periods:
Top shareholders of SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP |
13F
13D/G
|
Company |
6.2%
from 13D/G
|
3,258,360
|
$95,828,368 | — | 30 Sep 2024 | |
| Venrock Healthcare Capital Partners III, L.P. |
13D/G
|
— |
4.6%
|
2,685,448
|
$40,335,429 | $0 | 31 Dec 2024 | |
| FMR LLC |
13F
|
Company |
8.8%
|
7,623,881
|
$224,218,339 | — | 30 Sep 2024 | |
| Fairmount Funds Management LLC |
13F
|
Company |
4.7%
|
4,018,101
|
$118,172,350 | — | 30 Sep 2024 | |
| PERCEPTIVE ADVISORS LLC |
13F
|
Company |
3.3%
|
2,872,547
|
$84,481,607 | — | 30 Sep 2024 | |
| Venrock Adviser, LLC |
13F
|
Company |
3.1%
|
2,685,448
|
$78,979,026 | — | 30 Sep 2024 | |
| BlackRock, Inc. |
13F
|
Company |
3.1%
|
2,663,147
|
$78,323,155 | — | 30 Sep 2024 | |
| VANGUARD GROUP INC |
13F
|
Company |
2.9%
|
2,515,920
|
$73,993,207 | — | 30 Sep 2024 | |
| BRAIDWELL LP |
13F
|
Company |
2.5%
|
2,189,836
|
$64,403,077 | — | 30 Sep 2024 | |
| Commodore Capital LP |
13F
|
Company |
2.3%
|
1,988,084
|
$58,469,550 | — | 30 Sep 2024 | |
| STATE STREET CORP |
13F
|
Company |
1.8%
|
1,541,555
|
$45,337,133 | — | 30 Sep 2024 | |
| WELLINGTON MANAGEMENT GROUP LLP |
13F
|
Company |
1.7%
|
1,507,200
|
$44,326,752 | — | 30 Sep 2024 | |
| Paradigm Biocapital Advisors LP |
13F
|
Company |
1.5%
|
1,267,581
|
$37,279,557 | — | 30 Sep 2024 | |
| Assenagon Asset Management S.A. |
13F
|
Company |
1.3%
|
1,142,768
|
$33,608,807 | — | 30 Sep 2024 | |
| JANUS HENDERSON GROUP PLC |
13F
|
Company |
1.3%
|
1,120,531
|
$32,921,201 | — | 30 Sep 2024 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
13F
|
Company |
1.2%
|
1,055,000
|
$31,027,550 | — | 30 Sep 2024 | |
| Deep Track Capital, LP |
13F
|
Company |
1.2%
|
1,000,000
|
$29,410,000 | — | 30 Sep 2024 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
1%
|
891,048
|
$26,211,391 | — | 30 Sep 2024 | |
| Pictet Asset Management Holding SA |
13F
|
Company |
0.96%
|
825,706
|
$24,284,013 | — | 30 Sep 2024 | |
| FRANKLIN RESOURCES INC |
13F
|
Company |
0.88%
|
760,666
|
$23,322,019 | — | 30 Sep 2024 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
0.82%
|
707,586
|
$20,810,104 | — | 30 Sep 2024 | |
| Boxer Capital, LLC |
13F
|
Company |
0.81%
|
696,480
|
$20,483,477 | — | 30 Sep 2024 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
13F
|
Company |
0.8%
|
687,080
|
$20,207,023 | — | 30 Sep 2024 | |
| Avoro Capital Advisors LLC |
13F
|
Company |
0.69%
|
598,600
|
$17,604,826 | — | 30 Sep 2024 | |
| Polar Capital Holdings Plc |
13F
|
Company |
0.58%
|
500,000
|
$14,705,000 | — | 30 Sep 2024 | |
| Affinity Asset Advisors, LLC |
13F
|
Company |
0.58%
|
498,420
|
$14,658,532 | — | 30 Sep 2024 | |
| Jefferies Financial Group Inc. |
13F
|
Company |
0.53%
|
454,807
|
$13,375,874 | — | 30 Sep 2024 | |
| PRICE T ROWE ASSOCIATES INC /MD/ |
13F
|
Company |
0.5%
|
429,127
|
$12,621,000 | — | 30 Sep 2024 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.39%
|
333,275
|
$9,801,618 | — | 30 Sep 2024 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.36%
|
314,290
|
$9,243,269 | — | 30 Sep 2024 | |
| Ikarian Capital, LLC |
13F
|
Company |
0.35%
|
302,247
|
$8,889,085 | — | 30 Sep 2024 | |
| Blackstone Inc. |
13F
|
Company |
0.34%
|
292,995
|
$8,616,983 | — | 30 Sep 2024 | |
| EMERALD ADVISERS, LLC |
13F
|
Company |
0.34%
|
292,569
|
$8,604,454 | — | 30 Sep 2024 | |
| Woodline Partners LP |
13F
|
Company |
0.31%
|
264,256
|
$7,771,769 | — | 30 Sep 2024 | |
| BANK OF AMERICA CORP /DE/ |
13F
|
Company |
0.3%
|
257,797
|
$7,581,810 | — | 30 Sep 2024 | |
| EMERALD MUTUAL FUND ADVISERS TRUST |
13F
|
Company |
0.29%
|
253,550
|
$7,456,906 | — | 30 Sep 2024 | |
| MORGAN STANLEY |
13F
|
Company |
0.28%
|
243,742
|
$7,168,452 | — | 30 Sep 2024 | |
| Walleye Capital LLC |
13F
|
Company |
0.28%
|
243,372
|
$7,157,571 | — | 30 Sep 2024 | |
| BALYASNY ASSET MANAGEMENT L.P. |
13F
|
Company |
0.26%
|
227,950
|
$6,704,010 | — | 30 Sep 2024 | |
| Logos Global Management LP |
13F
|
Company |
0.23%
|
200,000
|
$5,882,000 | — | 30 Sep 2024 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
0.2%
|
169,314
|
$4,979,525 | — | 30 Sep 2024 | |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
13F
|
Company |
0.18%
|
156,481
|
$4,602,106 | — | 30 Sep 2024 | |
| SOROS FUND MANAGEMENT LLC |
13F
|
Company |
0.17%
|
145,000
|
$4,264,450 | — | 30 Sep 2024 | |
| Invesco Ltd. |
13F
|
Company |
0.16%
|
137,858
|
$4,054,403 | — | 30 Sep 2024 | |
| ARMISTICE CAPITAL, LLC |
13F
|
Company |
0.16%
|
136,000
|
$3,999,760 | — | 30 Sep 2024 | |
| Nuveen Asset Management, LLC |
13F
|
Company |
0.15%
|
125,290
|
$3,684,779 | — | 30 Sep 2024 | |
| BARCLAYS PLC |
13F
|
Company |
0.12%
|
105,467
|
$3,101,785 | — | 30 Sep 2024 | |
| HighVista Strategies LLC |
13F
|
Company |
0.12%
|
105,351
|
$3,098,373 | — | 30 Sep 2024 | |
| S.c.a. Candriam |
13F
|
Individual |
0.12%
|
105,000
|
$3,087,912 | — | 30 Sep 2024 | |
| Bank of New York Mellon Corp |
13F
|
Company |
0.12%
|
104,806
|
$3,082,344 | — | 30 Sep 2024 |
Institutional Holders of Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (SYRE) as of Q4 2024
As of 31 Dec 2024,
Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (SYRE) was held by
129 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
59,883,954 shares.
The largest 10 holders included
FMR LLC, Fairmount Funds Management LLC, RTW INVESTMENTS, LP, BlackRock, Inc., VANGUARD GROUP INC, Driehaus Capital Management LLC, VR Adviser, LLC, BRAIDWELL LP, PERCEPTIVE ADVISORS LLC, and COMMODORE CAPITAL LP.
This page lists
129
institutional shareholders reporting positions in this security
for the Q4 2024 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q4 2024 vs Q3 2024 Across Filers
Q3 2024 holders
118
Q4 2024 holders
129
Holder diff
11
| Investor | Q3 2024 Shares | Q4 2024 Shares | Share Diff | Share Chg % | Q3 2024 Value $ | Q4 2024 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.