Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (SYRE)

CUSIP: 00773J202

Q3 2024 13F Holders as of 30 Sep 2024

Security identity
Shares outstanding
86,389,920
Holder snapshot
Share change
+732,563
Put/Call ratio
217%
Reported price per share
$29.41
Number of holders
118
Value change
+$36,820,905
Number of buys
70
Number of sells
42

Security key

00773J202

Report period

Q3 2024

Institutions

118

Top holders

10

Ownership snapshot

Top shareholders of SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Lead holder
FMR LLC
13D/G signal
Evidence rows
50
Latest as of
30 Jun 2024
13F Lead comparable stake: 8.7% Showing first 8 of 50 holder rows. Open remaining rows

Rank 1 holder

FMR LLC

13F
Ownership
8.7%
Position
$176.51M
13F
Holder Evidence Ownership % Position 12M Net Δ As of
FMR LLC
13F
Company
13F
8.7%
$176,512,680
7,507,983 shares
30 Jun 2024
Fairmount Funds Management LLC
13F
Company
13F
4.7%
$94,465,555
4,018,101 shares
30 Jun 2024
RTW INVESTMENTS, LP
13F
Company
13F
3.8%
$76,604,044
3,258,360 shares
30 Jun 2024
PERCEPTIVE ADVISORS LLC
13F
Company
13F
3.5%
$71,259,233
3,031,018 shares
30 Jun 2024
Venrock Adviser, LLC
13F
Company
13F
3.1%
$63,134,882
2,685,448 shares
30 Jun 2024
BRAIDWELL LP
13F
Company
13F
2.9%
$59,116,788
2,514,538 shares
30 Jun 2024
BlackRock Finance, Inc.
13F
Company
13F
2.8%
$56,504,899
2,403,441 shares
30 Jun 2024
Commodore Capital LP
13F
Company
13F
2.3%
$46,739,855
1,988,084 shares
30 Jun 2024
Show 42 additional holder rows in the full holder list
Holder Evidence Ownership % Position 12M Net Δ As of
VANGUARD GROUP INC
13F
Company
13F
2.2%
$44,940,916
1,911,566 shares
30 Jun 2024
Avoro Capital Advisors LLC
13F
Company
13F
2.1%
$43,238,134
1,839,138 shares
30 Jun 2024
Deep Track Capital, LP
13F
Company
13F
2%
$41,299,241
1,756,667 shares
30 Jun 2024
STATE STREET CORP
13F
Company
13F
1.6%
$33,141,083
1,409,659 shares
30 Jun 2024
ADAGE CAPITAL PARTNERS GP, L.L.C.
13F
Company
13F
1.3%
$27,093,183
1,152,411 shares
30 Jun 2024
GOLDMAN SACHS GROUP INC
13F
Company
13F
1%
$20,996,381
893,083 shares
30 Jun 2024
WELLINGTON MANAGEMENT GROUP LLP
13F
Company
13F
0.92%
$18,712,691
795,946 shares
30 Jun 2024
GEODE CAPITAL MANAGEMENT, LLC
13F
Company
13F
0.89%
$18,008,295
765,834 shares
30 Jun 2024
FRANKLIN RESOURCES INC
13F
Company
13F
0.86%
$17,442,163
741,904 shares
30 Jun 2024
CITADEL ADVISORS LLC
13F
Company
13F
0.82%
$16,635,347
707,586 shares
30 Jun 2024
Boxer Capital, LLC
13F
Company
13F
0.81%
$16,374,245
696,480 shares
30 Jun 2024
DRIEHAUS CAPITAL MANAGEMENT LLC
13F
Company
13F
0.8%
$16,153,251
687,080 shares
30 Jun 2024
JANUS HENDERSON GROUP PLC
13F
Company
13F
0.78%
$15,916,739
673,867 shares
30 Jun 2024
FARALLON CAPITAL MANAGEMENT LLC
13F
Company
13F
0.77%
$15,657,660
666,000 shares
30 Jun 2024
Logos Global Management LP
13F
Company
13F
0.67%
$13,518,250
575,000 shares
30 Jun 2024
Affinity Asset Advisors, LLC
13F
Company
13F
0.59%
$12,070,504
513,420 shares
30 Jun 2024
Polar Capital Holdings Plc
13F
Company
13F
0.58%
$11,755,000
500,000 shares
30 Jun 2024
First Turn Management, LLC
13F
Company
13F
0.54%
$10,918,867
464,435 shares
30 Jun 2024
Darwin Global Management, Ltd.
13F
Company
13F
0.52%
$10,265,828
452,040 shares
30 Jun 2024
MORGAN STANLEY
13F
Company
13F
0.47%
$9,612,133
408,853 shares
30 Jun 2024
Pictet Asset Management Holding SA
13F
Company
13F
0.45%
$9,089,366
386,617 shares
30 Jun 2024
PRICE T ROWE ASSOCIATES INC /MD/
13F
Company
13F
0.36%
$7,242,000
307,976 shares
30 Jun 2024
Blackstone Inc.
13F
Company
13F
0.34%
$6,888,312
292,995 shares
30 Jun 2024
VOLORIDGE INVESTMENT MANAGEMENT, LLC
13F
Company
13F
0.32%
$6,470,563
275,226 shares
30 Jun 2024
BALYASNY ASSET MANAGEMENT L.P.
13F
Company
13F
0.32%
$6,409,672
272,636 shares
30 Jun 2024
Woodline Partners LP
13F
Company
13F
0.3%
$6,174,102
262,616 shares
30 Jun 2024
Ghost Tree Capital, LLC
13F
Company
13F
0.29%
$5,883,072
250,237 shares
30 Jun 2024
Avidity Partners Management LP
13F
Company
13F
0.23%
$4,584,450
195,000 shares
30 Jun 2024
BANK OF AMERICA CORP /DE/
13F
Company
13F
0.22%
$4,494,383
191,169 shares
30 Jun 2024
Walleye Capital LLC
13F
Company
13F
0.17%
$3,545,778
150,820 shares
30 Jun 2024
STEMPOINT CAPITAL LP
13F
Company
13F
0.17%
$3,537,080
150,450 shares
30 Jun 2024
SOROS FUND MANAGEMENT LLC
13F
Company
13F
0.17%
$3,408,950
145,000 shares
30 Jun 2024
ARMISTICE CAPITAL, LLC
13F
Company
13F
0.16%
$3,197,360
136,000 shares
30 Jun 2024
GREAT POINT PARTNERS LLC
13F
Company
13F
0.16%
$3,164,728
134,612 shares
30 Jun 2024
Bank of New York Mellon Corp
13F
Company
13F
0.14%
$2,766,798
117,686 shares
30 Jun 2024
Nuveen Asset Management, LLC
13F
Company
13F
0.14%
$2,753,962
117,140 shares
30 Jun 2024
HighVista Strategies LLC
13F
Company
13F
0.13%
$2,669,561
113,550 shares
30 Jun 2024
SUVRETTA CAPITAL MANAGEMENT, LLC
13F
Company
13F
0.12%
$2,522,858
107,310 shares
30 Jun 2024
S.c.a. Candriam
13F
Individual
13F
0.12%
$2,468,435
105,000 shares
30 Jun 2024
Integral Health Asset Management, LLC
13F
Company
13F
0.12%
$2,351,000
100,000 shares
30 Jun 2024
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
13F
Company
13F
0.11%
$2,308,235
98,181 shares
30 Jun 2024
Jefferies Financial Group Inc.
13F
Company
13F
0.11%
$2,293,941
97,573 shares
30 Jun 2024
How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q3 2024

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions
118
Shares
51,375,323
Rows loaded
118
Investor Option Weight % Change % Reported value * Price Shares Share Change Activity Report Period

* Reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. An asterisk next to the price means the price is likely invalid.

Compare Q3 2024 vs Q2 2024 Across Filers

Q2 2024 holders
106
Q3 2024 holders
118
Holder diff
12
Investor Q2 2024 Shares Q3 2024 Shares Share Diff Share Chg % Q2 2024 value Q3 2024 value Value change Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
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