Quick Takeaways
- PERCEPTIVE ADVISORS LLC filed SCHEDULE 13G for SPYRE THERAPEUTICS, INC. Common Stock, $0.0001 Par Value Per Share (SYRE).
- Disclosed ownership: 5%.
- Date of event: 15 Apr 2026.
PERCEPTIVE ADVISORS LLC - 15 Apr 2026 SCHEDULE 13G Report for SPYRE THERAPEUTICS, INC. Common Stock, $0.0001 Par Value Per Share (SYRE)
- Filing Manager
- PERCEPTIVE ADVISORS LLC
- Reporting Manager
- Perceptive Advisors LLC
- Symbol
- SYRE
- Shares outstanding
- 86,389,920 shares
- Disclosed Ownership
- 4,319,496 shares
- Ownership
- 5%
- Form type
- SCHEDULE 13G
- Filing time
- 22 Apr 2026, 16:00:02 UTC
- Date of event
- 15 Apr 2026
- Previous filing
- 14 Feb 2025
- SEC
- View on sec.gov
Quoteable Key Fact
"PERCEPTIVE ADVISORS LLC disclosed 5% ownership in SPYRE THERAPEUTICS, INC. Common Stock, $0.0001 Par Value Per Share (SYRE) on 15 Apr 2026."
What Changed
- Previous schedule filing date: 14 Feb 2025.
- Current filing was accepted on 22 Apr 2026, 16:00.
Why This Matters
- This page explains what this Schedule 13D/13G filing tells you before manager-level rows.
- You can verify ownership claims directly against the original SEC filing.
Source Evidence
Backed by Schedule 13D/13G
See Original Filing
Beneficial ownership values are sourced from the original SEC Schedule 13D/13G filing.
Reporting Managers (3)
| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Perceptive Advisors LLC | 5% | 4,319,496 | 0 | 4,319,496 | /s/ Joseph Edelman | Joseph Edelman, Managing Member | |
| Joseph Edelman | 5% | 4,319,496 | 0 | 4,319,496 | /s/ Joseph Edelman | Joseph Edelman | |
| Perceptive Life Sciences Master Fund, Ltd. | 5% | 4,319,496 | 0 | 4,319,496 | /s/ Joseph Edelman | Joseph Edelman, Managing Member |