How many institutions held SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value in Q4 2023?

54 institutional investors reported SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value for Q4 2023. Use the holders table for investor-level position and value details.

Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (SYRE)

Q: What does CUSIP 00773J202 represent in this 13F holders report?

CUSIP 00773J202 is the security identifier for SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value used to aggregate holder disclosures.

CUSIP: 00773J202

Q4 2023 13F Holders as of 31 Dec 2023

Security type / class: Equity / Common Stock, $0.0001 par value
Total 13F shares: 28,010,905
Total 13F value: $600,997,673
Share change: +24,367,716
Put/Call ratio: 6.7%
SEC-reported price per share: $21.52
Number of holders: 54
Value change: +$524,495,293
Number of buys: 42
Number of sells: 8
Shares outstanding: 96,768,779

Security key

00773J202

Report period

Q4 2023

Institutions

Top holders

SYRE full security history Ownership snapshot Full 13F holder table Newer quarter: Q2 2026 Spyre Therapeutics, Inc. SEC filings Spyre Therapeutics, Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 00773J202

Newer quarter: Q2 2026

Recent filing periods:

Q2 2026

Ownership snapshot

Top reported holders of SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 par value (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

DRIEHAUS CAPITAL MANAGEME...

Disclosed value leader

DRIEHAUS CAPITAL MANAGEME...

Comparable rows

15/15

Latest evidence

30 Sep 2023

13F Lead comparable stake: 0.83% Showing 1-6 of 15 holder rows.

Quick read

DRIEHAUS CAPITAL MANAGEMENT LLC leads the comparable SEC ownership view at 0.83%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens DRIEHAUS CAPITAL MANAGEMENT LLC's linked filing trail.

Comparable ownership Top 5

DRIEHAUS CAPITAL MANAGEMENT LLC 0.83%

Fairmount Funds Management LLC 0.39%

Polar Capital Holdings Plc 0.31%

WELLINGTON MANAGEMENT GROUP LLP 0.31%

Affinity Asset Advisors, LLC 0.25%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
DRIEHAUS CAPITAL MANAGEMENT LLC	13F Company 13F	0.83%	$9,810,449 800,853 shares	—	30 Sep 2023
Fairmount Funds Management LLC	13F Company 13F	0.39%	$4,635,657 378,421 shares	—	30 Sep 2023
Polar Capital Holdings Plc	13F Company 13F	0.31%	$3,675,000 300,000 shares	—	30 Sep 2023
WELLINGTON MANAGEMENT GROUP LLP	13F Company 13F	0.31%	$3,674,130 299,929 shares	—	30 Sep 2023
Affinity Asset Advisors, LLC	13F Company 13F	0.25%	$2,968,138 242,297 shares	—	30 Sep 2023
Logos Global Management LP	13F Company 13F	0.22%	$2,572,500 210,000 shares	—	30 Sep 2023

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2023

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

28,010,905

Rows available

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q4 2023 vs Q3 2023 Across Filers

Q3 2023 holders

Q4 2023 holders

Holder diff

Investor	Q3 2023 Shares	Q4 2023 Shares	Share Diff	Share Chg %	Q3 2023 value	Q4 2023 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend