Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (SYRE)

Q: What does CUSIP 00773J202 represent in this 13F holders report?

CUSIP 00773J202 is the security identifier for SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share used to aggregate holder disclosures.

Q: How many institutions held SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share in Q4 2023?

54 institutional investors reported SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share for Q4 2023. Use the holders table for investor-level position and value details.

CUSIP: 00773J202

Q4 2023 13F Holders as of 31 Dec 2023

Type / Class: Equity / Common Stock, $0.0001 Par Value Per Share
Shares outstanding: 86,389,920
Total 13F shares: 28,010,905
Share change: +24,367,716
Total reported value: $600,997,673
Put/Call ratio: 6.7%
Price per share: $21.52
Number of holders: 54
Value change: +$524,495,293
Number of buys: 42
Number of sells: 8

Security key

00773J202

Report period

Q4 2023

Institutions

Top holders

SYRE full security history Newer quarter: Q1 2024 Previous quarter: Q3 2023 Spyre Therapeutics, Inc. SEC filings Spyre Therapeutics, Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 00773J202

Newer quarter: Q1 2024 Previous quarter: Q3 2023

Recent filing periods:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Top shareholders of SYRE - Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
DRIEHAUS CAPITAL MANAGEMENT LLC	13F	Company	0.93%	800,853	$9,810,449	—	30 Sep 2023	13F
Fairmount Funds Management LLC	13F	Company	0.44%	378,421	$4,635,657	—	30 Sep 2023	13F
Polar Capital Holdings Plc	13F	Company	0.35%	300,000	$3,675,000	—	30 Sep 2023	13F
WELLINGTON MANAGEMENT GROUP LLP	13F	Company	0.35%	299,929	$3,674,130	—	30 Sep 2023	13F
Affinity Asset Advisors, LLC	13F	Company	0.28%	242,297	$2,968,138	—	30 Sep 2023	13F
Logos Global Management LP	13F	Company	0.24%	210,000	$2,572,500	—	30 Sep 2023	13F
EcoR1 Capital, LLC	13F	Company	0.23%	199,996	$2,449,951	—	30 Sep 2023	13F
SUVRETTA CAPITAL MANAGEMENT, LLC	13F	Company	0.19%	162,395	$1,989,339	—	30 Sep 2023	13F
Rock Springs Capital Management LP	13F	Company	0.16%	136,556	$1,672,811	—	30 Sep 2023	13F
Commodore Capital LP	13F	Company	0.13%	116,324	$1,424,969	—	30 Sep 2023	13F
CITADEL ADVISORS LLC	13F	Company	0.11%	97,053	$1,188,899	—	30 Sep 2023	13F
PERCEPTIVE ADVISORS LLC	13F	Company	0.09%	81,116	$993,671	—	30 Sep 2023	13F
Aisling Capital Management LP	13F	Company	0.08%	67,645	$828,652	—	30 Sep 2023	13F
MILLENNIUM MANAGEMENT LLC	13F	Company	0.04%	37,813	$463,209	—	30 Sep 2023	13F
VANGUARD GROUP INC	13F	Company	0.04%	33,077	$405,193	—	30 Sep 2023	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	0.03%	26,800	$328,396	—	30 Sep 2023	13F
RENAISSANCE TECHNOLOGIES LLC	13F	Company	0.03%	23,229	$285,000	—	30 Sep 2023	13F
BlackRock Finance, Inc.	13F	Company	0.02%	19,768	$242,158	—	30 Sep 2023	13F
ACADIAN ASSET MANAGEMENT LLC	13F	Company	0.01%	11,888	$145,000	—	30 Sep 2023	13F
Avoro Capital Advisors LLC	13F	Company	0.01%	11,458	$140,361	—	30 Sep 2023	13F
ROYAL BANK OF CANADA	13F	Company	0%	437	$5,000	—	30 Sep 2023	13F
Tower Research Capital LLC (TRC)	13F	Company	0%	422	$5,170	—	30 Sep 2023	13F
OSAIC HOLDINGS, INC.	13F	Company	0%	283	$3,466	—	30 Sep 2023	13F
IFP Advisors, Inc	13F	Company	0%	114	$1,397	—	30 Sep 2023	13F
MORGAN STANLEY	13F	Company	0%	46	$564	—	30 Sep 2023	13F
JPMORGAN CHASE & CO	13F	Company	0%	41	$502	—	30 Sep 2023	13F
WELLS FARGO & COMPANY/MN	13F	Company	0%	22	$270	—	30 Sep 2023	13F
Anthony G. Quinn	3/4/5	President & CEO, Director	— class O/S missing	816,835	$579,952	—	16 Mar 2022	3/4/5
Marcio Souza	3/4/5	Director	— class O/S missing	90,000	$63,900	—	25 Aug 2022	3/4/5
Jonathan Alspaugh	3/4/5	President and CFO	— class O/S missing	19,787,969	—	—	22 Jun 2023	3/4/5
Alison Frances Lawton	3/4/5	Director	— class O/S missing	1,950,000	—	—	22 Jun 2023	3/4/5
Hunter C. Smith	3/4/5	Director	— class O/S missing	1,950,000	—	—	22 Jun 2023	3/4/5
Ivana Magovcevic-Liebisch	3/4/5	Director	— class O/S missing	1,950,000	—	—	22 Jun 2023	3/4/5
Russell J. Cox	3/4/5	Director	— class O/S missing	1,950,000	—	—	22 Jun 2023	3/4/5
Jeff Marc Goldberg	3/4/5	President and CEO, Director	— class O/S missing	1,884,838	—	—	29 Nov 2022	3/4/5
Linda L. Neuman	3/4/5	Chief Medical Officer	— class O/S missing	550,000	—	—	23 Feb 2023	3/4/5
James Paul Kastenmayer	3/4/5	General Counsel	— class O/S missing	500,000	—	—	23 Feb 2023	3/4/5
Jr. Michael Conick Hanley	3/4/5	Chief Business Officer	— class O/S missing	500,000	—	—	23 Feb 2023	3/4/5
Leslie Sloan	3/4/5	Chief Operating Officer	— class O/S missing	130,000	—	—	23 Aug 2022	3/4/5
Armen Shanafelt	3/4/5	Director	— class O/S missing	43,000	—	—	07 Jun 2022	3/4/5
Bryan Lawlis V	3/4/5	Director	— class O/S missing	43,000	—	—	07 Jun 2022	3/4/5
Sandesh Mahatme	3/4/5	Director	— class O/S missing	43,000	—	—	07 Jun 2022	3/4/5
BAKER BROS. ADVISORS LP	3/4/5	Director	— class O/S missing	40,000	—	—	08 Jun 2021	3/4/5
Steven Weber	3/4/5	VP, Controller&Princ Acctg Off	— class O/S missing	30,000	—	—	17 Feb 2022	3/4/5

Institutional Holders of Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (SYRE) as of Q4 2023

As of 31 Dec 2023, Spyre Therapeutics, Inc. - Common Stock, $0.0001 Par Value Per Share (SYRE) was held by 54 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 28,010,905 shares. The largest 10 holders included FMR LLC, PERCEPTIVE ADVISORS LLC, VR Adviser, LLC, RTW INVESTMENTS, LP, Deep Track Capital, LP, COMMODORE CAPITAL LP, Avoro Capital Advisors LLC, ADAGE CAPITAL PARTNERS GP, L.L.C., Cormorant Asset Management, LP, and EcoR1 Capital, LLC. This page lists 54 institutional shareholders reporting positions in this security for the Q4 2023 filing period.

Investor	Option	Weight %	Change %	Value $	* Price	Shares	Share Change	Activity	Report Period

Compare Q4 2023 vs Q3 2023 Across Filers

Q3 2023 holders

Q4 2023 holders

Holder diff

Investor	Q3 2023 Shares	Q4 2023 Shares	Share Diff	Share Chg %	Q3 2023 Value $	Q4 2023 Value $	Value Diff $	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.