RTW INVESTMENTS, LP - 31 Dec 2024 SCHEDULE 13G/A Report for Spyre Therapeutics, Inc. Common Stock, par value $0.0001 per share (SYRE)

Filing Manager: RTW INVESTMENTS, LP
Reporting Manager: RTW Investments, LP
Security: Spyre Therapeutics, Inc. Common Stock, par value $0.0001 per share
Symbol: SYRE
Shares outstanding: 58,419,290 shares
Disclosed Ownership: 3,621,996 shares
Ownership: 6.2%
Form type: SCHEDULE 13G/A
Filing time: 14 Feb 2025, 09:00:03 UTC
Date of event: 31 Dec 2024
SEC: View on sec.gov

Reporting Managers (2)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
RTW Investments, LP	6.2%	3,621,996	0	3,621,996	/s/ Roderick Wong, M.D.	Roderick Wong, M.D., Managing Partner
Roderick Wong, M.D.	6.2%	3,621,996	0	3,621,996	/s/ Roderick Wong, M.D.	Roderick Wong, M.D.