BAKER BROS. ADVISORS LP

Insider Reports History

Identity Names, identifiers, and filing context for this profile. 1 identity field
Reporting-owner location
New York, NY
SEC source record Original filing metadata and source links for verification. 1 source field
Latest reporting-owner signature
By: Baker Bros. Advisors LP, Name: Scott L. Lessing, Title: President /s/ Scott L. Lessing
Source: Latest parsed Forms 3/4/5 signature
Source evidence Original filing metadata and source links for verification. 1 source field
Transaction source note
Rows are grouped by transaction date from the original SEC filing. Open the aggregated insider activity page to review issuer-level activity across dates.

Reported holdings for BAKER BROS. ADVISORS LP

Form 4 holding Director, 10%+ Owner

INCYTE CORP

Security class
Common Stock
Shares / value
28,205,760
Estimated value
$2,654,726,131
Report date
30 Jun 2026
Price
$94.12
Ownership
Indirect
Form 4 holding Director

BeOne Medicines Ltd.

Security class
American Depositary Shares
Shares / value
8,068,411
Estimated value
$2,097,786,860
Report date
11 Jun 2026
Price
$260.00
Ownership
Indirect
Form 4 holding Director

Denali Therapeutics Inc.

Security class
$0.01 Prefunded Warrants
Shares / value
25,996,310
Estimated value
$454,675,461
Report date
11 Dec 2025
Price
$17.49
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

Kymera Therapeutics, Inc.

Security class
Prefunded Warrants
Shares / value
10,225,962
Estimated value
$449,941,305
Report date
30 Jun 2025
Price
$44.00
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Former 10% owner

Celcuity Inc.

Security class
Common Stock
Shares / value
4,372,852
Estimated value
$448,217,330
Report date
14 Jul 2026
Price
$102.50
Ownership
Indirect
Form 4 holding Director, 10%+ Owner

BICYCLE THERAPEUTICS PLC

Security class
American Depositary Shares
Shares / value
10,018,674
Estimated value
$153,412,999
Report date
02 Jan 2026
Price
$15.34
Ownership
Indirect
Form 4 holding Director, 10%+ Owner

Replimune Group, Inc.

Security class
Common Stock
Shares / value
10,116,095
Estimated value
$125,641,900
Report date
05 Mar 2025
Price
$12.42
Ownership
Indirect
Form 4 holding Director, 10%+ Owner

Prelude Therapeutics Inc

Security class
Warrants to purchase Common Stock
Shares / value
20,105,994
Estimated value
$89,268,602
Report date
21 Apr 2026
Price
$4.44
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

Immunocore Holdings plc

Security class
American Depositary Shares
Shares / value
2,144,060
Estimated value
$63,379,057
Report date
17 Mar 2025
Price
$29.56
Ownership
Indirect
Form 4 holding Director, 10%+ Owner

Replimune Group, Inc.

Security class
2026 $0.0001 Prefunded Warrants
Shares / value
2,609,946
Estimated value
$31,475,687
Report date
11 Aug 2026
Price
$12.06
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

INCYTE CORP

Security class
Common Stock
Shares / value
281,190
Estimated value
$26,465,602
Report date
30 Jun 2026
Price
$94.12
Ownership
Direct
Form 4 holding Director

BeOne Medicines Ltd.

Security class
American Depositary Shares
Shares / value
10,418
Estimated value
$2,708,680
Report date
11 Jun 2026
Price
$260.00
Ownership
Direct
Form 4 holding Former 10% Owner

Atreca, Inc.

Security class
Class A common stock
Shares / value
2,971,128
Estimated value
$1,195,879
Report date
19 Oct 2023
Price
$0.4025
Ownership
Indirect
Form 4 holding Director, Former 10% Owner

Neurogene Inc.

Security class
Common Stock
Shares / value
414,547
Estimated value
$287,198
Report date
18 Dec 2023
Price
$0.6928
Ownership
Indirect
Form 4 holding Director, Former 10% Owner

Neurogene Inc.

Security class
Common Stock
Shares / value
113
Estimated value
$78
Report date
18 Dec 2023
Price
$0.6928
Ownership
Direct
Form 4 holding Director

DBV Technologies S.A.

Security class
First Pre-Funded Warrant
Shares / value
25,005,240
Estimated value
Report date
27 Mar 2025
Price
Ownership
Indirect
Underlying class
Ordinary Shares
Underlying amount
Form 4 holding 10%+ Owner

BELLICUM PHARMACEUTICALS, INC

Security class
Warrants (right to buy)
Shares / value
14,217,844
Estimated value
Report date
22 Nov 2023
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

vTv Therapeutics Inc.

Security class
Prefunded Warrants
Shares / value
5,176,974
Estimated value
Report date
03 Sep 2025
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding 10%+ Owner

SERA PROGNOSTICS, INC.

Security class
Common Stock
Shares / value
5,065,736
Estimated value
Report date
12 Feb 2025
Price
Ownership
Indirect
Form 4 holding Director, Former 10% Owner

Neurogene Inc.

Security class
Prefunded Warrants
Shares / value
2,656,101
Estimated value
Report date
18 Dec 2023
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

vTv Therapeutics Inc.

Security class
Common Warrant
Shares / value
2,400,605
Estimated value
Report date
03 Sep 2025
Price
Ownership
Indirect
Underlying class
Common Stock or Prefunded Warrant
Underlying amount
Form 4 holding Director, Former 10% Owner

Neoleukin Therapeutics, Inc.

Security class
Pre-funded Warrants
Shares / value
1,521,176
Estimated value
Report date
05 Oct 2023
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

vTv Therapeutics Inc.

Security class
Common Stock
Shares / value
135,946
Estimated value
Report date
03 Sep 2025
Price
Ownership
Indirect
Form 4 holding Director

TScan Therapeutics, Inc.

Security class
Non- Qualified Stock Option (right to buy)
Shares / value
67,000
Estimated value
Report date
20 May 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

BeiGene, Ltd.

Security class
Share Option (Right to Buy)
Shares / value
45,500
Estimated value
Report date
21 May 2025
Price
Ownership
Indirect
Underlying class
Ordinary Shares
Underlying amount
Form 4 holding Director, 10%+ Owner

Replimune Group, Inc.

Security class
Non-Qualified Stock Option (right to buy)uy)
Shares / value
44,500
Estimated value
Report date
01 Apr 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

Aeglea BioTherapeutics, Inc.

Security class
Non-Qualified Stock Option (right to buy)
Shares / value
40,000
Estimated value
Report date
08 Jun 2021
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

BICYCLE THERAPEUTICS PLC

Security class
Share Option (Right to Buy)
Shares / value
38,000
Estimated value
Report date
02 Jan 2026
Price
Ownership
Indirect
Underlying class
American Depositary Shares
Underlying amount
Form 4 holding Director, 10%+ Owner

Prelude Therapeutics Inc

Security class
Non-Qualified Stock Option (right to buy)
Shares / value
38,000
Estimated value
Report date
09 Jun 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

ACADIA PHARMACEUTICALS INC

Security class
Non- Qualified Stock Option (right to buy)
Shares / value
32,008
Estimated value
Report date
29 May 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

Denali Therapeutics Inc.

Security class
Non-Qualified Stock Option (right to buy)uy)
Shares / value
31,695
Estimated value
Report date
03 Jun 2025
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

Talis Biomedical Corp

Security class
Non- Qualified Stock Option (right to buy)
Shares / value
23,685
Estimated value
Report date
09 Jun 2023
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

Prelude Therapeutics Inc

Security class
Non- Qualified Stock Option (right to buy)
Shares / value
23,500
Estimated value
Report date
14 Jun 2024
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

Denali Therapeutics Inc.

Security class
Non- Qualified Stock Option (right to buy)
Shares / value
19,226
Estimated value
Report date
03 Jun 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

Kodiak Sciences Inc.

Security class
Non-Qualified Stock Options (right to buy)
Shares / value
17,731
Estimated value
Report date
30 Jun 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

INCYTE CORP

Security class
Non-Qualified Stock Options (right to buy)
Shares / value
6,111
Estimated value
Report date
08 Jun 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, 10%+ Owner

Kymera Therapeutics, Inc.

Security class
Non-Qualified Stock Option (right to buy)
Shares / value
6,068
Estimated value
Report date
24 Jun 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director

DBV Technologies S.A.

Security class
BS Warrant
Shares / value
0
Estimated value
Report date
12 Jan 2026
Price
Ownership
Indirect
Underlying class
Second Pre-Funded Warrant
Underlying amount
Form 4 holding Director

Immunocore Holdings plc

Security class
2.5% Convertible Senior Notes due 2030
Shares / value
0
Estimated value
Report date
17 Mar 2025
Price
Ownership
Indirect
Underlying class
American Depositary Shares
Underlying amount
Form 4 holding Director, 10%+ Owner

INCYTE CORP

Security class
Non-Qualified Stock Options
Shares / value
0
Estimated value
Report date
08 May 2026
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount
Form 4 holding Director, Former 10% Owner

Seagen Inc.

Security class
Common Stock
Shares / value
0
Estimated value
Report date
14 Dec 2023
Price
$229.00
Ownership
Direct
Form 4 holding Director, Former 10% Owner

Seagen Inc.

Security class
Common Stock
Shares / value
0
Estimated value
Report date
14 Dec 2023
Price
$229.00
Ownership
Indirect
Form 4 holding Director, Former 10% Owner

Seagen Inc.

Security class
Stock Options (right to buy)
Shares / value
0
Estimated value
Report date
14 Dec 2023
Price
Ownership
Indirect
Underlying class
Common Stock
Underlying amount

Insider Reports Filed by BAKER BROS. ADVISORS LP

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