| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 10.9% | +14% | $551M | $128M | 8.68M | +30.2% | Baker Bros. Advisors LP | 09 Dec 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 8.5% | $436M | 6.87M | BVF PARTNERS L P/IL | 11 Dec 2025 | |||
| FMR LLC | 8.2% | +20% | $333M | $83.2M | 5.88M | +33.3% | FMR LLC | 30 Sep 2025 |
| WELLINGTON MANAGEMENT GROUP LLP | 7.7% | -16.7% | $241M | -$28M | 5.37M | -10.4% | Wellington Management Group LLP | 30 Jun 2025 |
| VANGUARD GROUP INC | 8.05% | $174M | 5.23M | The Vanguard Group | 31 Mar 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 7.1% | $289M | 5.1M | T. Rowe Price Associates, Inc. | 30 Sep 2025 | |||
| BlackRock, Inc. | 5.4% | $166M | 3.8M | BlackRock, Inc. | 30 Jun 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 80.9M | $4.58B | +$138M | $56.60 | 206 |
| 2025 Q2 | 78.8M | $3.44B | +$271M | $43.64 | 208 |
| 2025 Q1 | 72.8M | $2B | +$5.35M | $27.37 | 171 |
| 2024 Q4 | 71.7M | $2.89B | +$14.4M | $40.23 | 177 |
| 2024 Q3 | 69.1M | $3.27B | +$183K | $47.33 | 174 |
| 2024 Q2 | 67.4M | $2.01B | +$5.55M | $29.85 | 153 |
| 2024 Q1 | 67.2M | $2.7B | +$297M | $40.20 | 161 |
| 2023 Q4 | 60.5M | $1.54B | +$89M | $25.46 | 134 |
| 2023 Q3 | 57.4M | $797M | -$18.2M | $13.90 | 120 |
| 2023 Q2 | 58.2M | $1.34B | +$29.1M | $22.99 | 124 |
| 2023 Q1 | 56.9M | $1.68B | +$23.1M | $29.63 | 123 |
| 2022 Q4 | 56.2M | $1.4B | +$98.5M | $24.96 | 116 |
| 2022 Q3 | 52.9M | $1.15B | +$29.2M | $21.77 | 119 |
| 2022 Q2 | 49.4M | $974M | +$16.5M | $19.69 | 99 |
| 2022 Q1 | 45.7M | $1.93B | +$62.4M | $42.32 | 124 |
| 2021 Q4 | 43M | $2.73B | +$129M | $63.49 | 123 |
| 2021 Q3 | 34.6M | $2.04B | +$492M | $58.74 | 115 |
| 2021 Q2 | 26.5M | $1.28B | +$188M | $48.50 | 109 |
| 2021 Q1 | 22.2M | $862M | +$92.7M | $38.86 | 94 |
| 2020 Q4 | 20.3M | $1.25B | +$53M | $62.00 | 74 |
| 2020 Q3 | 16.8M | $543M | +$543M | $32.31 | 51 |