Insider Trading & Ownership of BAKER BROS. ADVISORS LP

Location
New York, NY
Summary
The estimated value of insider holdings of BAKER BROS. ADVISORS LP is at least $9,451,097,689 dollars as of 14 Jan 2026. BAKER BROS. ADVISORS LP is the Director, 10%+ Owner of INCYTE CORP and owns shares of INCYTE CORP (INCY) stock worth about $2.92B. BAKER BROS. ADVISORS LP is the Director of BeiGene, Ltd. and owns shares of BeOne Medicines Ltd. (ONC) stock worth about $2.14B. BAKER BROS. ADVISORS LP is the Director, 10%+ Owner of Kymera Therapeutics, Inc. and owns shares of Kymera Therapeutics, Inc. (KYMR) stock worth about $1.13B. BAKER BROS. ADVISORS LP is the Director of MADRIGAL PHARMACEUTICALS, INC. and owns shares of MADRIGAL PHARMACEUTICALS, INC. (MDGL) stock worth about $764.08M. BAKER BROS. ADVISORS LP is the Director, 10%+ Owner of ACADIA PHARMACEUTICALS INC and owns shares of ACADIA PHARMACEUTICALS INC (ACAD) stock worth about $688.34M. BAKER BROS. ADVISORS LP is the Director of Denali Therapeutics Inc. and owns shares of Denali Therapeutics Inc. (DNLI) stock worth about $510.83M. BAKER BROS. ADVISORS LP is the Director, 10%+ Owner of Kodiak Sciences Inc. and owns shares of Kodiak Sciences Inc. (KOD) stock worth about $422.25M. BAKER BROS. ADVISORS LP is the 10%+ Owner of Celcuity Inc. and owns shares of Celcuity Inc. (CELC) stock worth about $418.44M. BAKER BROS. ADVISORS LP is the Director, 10%+ Owner of BICYCLE THERAPEUTICS PLC and owns shares of BICYCLE THERAPEUTICS PLC (BCYC) stock worth about $153.41M. BAKER BROS. ADVISORS LP is the Director, 10%+ Owner of Replimune Group, Inc. and owns shares of Replimune Group, Inc. (REPL) stock worth about $125.64M. BAKER BROS. ADVISORS LP is the Director of Kiniksa Pharmaceuticals International, plc and owns shares of Kiniksa Pharmaceuticals International, plc (KNSA) stock worth about $70.49M. BAKER BROS. ADVISORS LP is the Director of Immunocore Holdings plc and owns shares of Immunocore Holdings plc (IMCR) stock worth about $63.38M. BAKER BROS. ADVISORS LP is the 10%+ Owner of Entrada Therapeutics, Inc. and owns shares of Entrada Therapeutics, Inc. (TRDA) stock worth about $42.56M. BAKER BROS. ADVISORS LP is the Former 10% Owner of Atreca, Inc. and owns shares of Atreca, Inc. stock worth about $1.2M. BAKER BROS. ADVISORS LP is the Former 10% owner of KALA BIO, Inc. and owns shares of KALA BIO, Inc. (KALA) stock worth about $588.1K. BAKER BROS. ADVISORS LP is the Director, Former 10% Owner of Neurogene Inc. and owns shares of Neurogene Inc. (NGNE) stock worth about $287.3K.
Signature
By: Baker Bros. Advisors LP, Name: Scott L. Lessing, Title: President /s/ Scott L. Lessing
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Ownership of BAKER BROS. ADVISORS LP

Symbol Company Relationship Holdings Value Past Year Net Change Change % Report Period
INCY INCYTE CORP Director, 10%+ Owner $2,918,691,806 31 Dec 2025
ONC, BEIGF BeiGene, Ltd. Director $2,136,757,882 -$190,535,020 -8.2% 21 May 2025
KYMR Kymera Therapeutics, Inc. Director, 10%+ Owner $1,134,150,081 +$230,183,852 +25% 11 Dec 2025
MDGL MADRIGAL PHARMACEUTICALS, INC. Director $764,076,617 +$61,921,024 +8.8% 18 Aug 2025
ACAD ACADIA PHARMACEUTICALS INC Director, 10%+ Owner $688,336,586 29 May 2025
DNLI Denali Therapeutics Inc. Director $510,833,810 +$39,977,138 +8.5% 11 Dec 2025
KOD Kodiak Sciences Inc. Director, 10%+ Owner $422,251,756 +$60,000,008 +17% 18 Dec 2025
CELC Celcuity Inc. 10%+ Owner $418,436,263 +$9,571,319 +2.3% 08 Sep 2025
BCYC BICYCLE THERAPEUTICS PLC Director, 10%+ Owner $153,412,999 02 Jan 2026
REPL Replimune Group, Inc. Director, 10%+ Owner $125,641,900 05 Mar 2025
KNSA Kiniksa Pharmaceuticals International, plc Director $70,493,593 03 Jun 2025
IMCR Immunocore Holdings plc Director $63,379,057 +$23,993,224 +61% 15 May 2025
TRDA Entrada Therapeutics, Inc. 10%+ Owner $42,564,061 +$1,614,433 +3.9% 20 Nov 2025
BCEL Atreca, Inc. Former 10% Owner $1,195,879 19 Oct 2023
KALA KALA BIO, Inc. Former 10% owner $588,123 -$1,056,722 -64% 30 Sep 2025
NGNE Neurogene Inc. Director, Former 10% Owner $287,276 18 Dec 2023
IGMS IGM Biosciences, Inc. Former 10% owner and director $0 14 Aug 2025
SYRE Aeglea BioTherapeutics, Inc. Director 08 Jun 2021
BLCM BELLICUM PHARMACEUTICALS, INC 10%+ Owner 22 Nov 2023
DBVT, DBVTF DBV Technologies S.A. Director 12 Jan 2026
PRLD Prelude Therapeutics Inc Director, 10%+ Owner 12 Jun 2025
SGEN Seagen Inc. Director, Former 10% Owner 14 Dec 2023
SERA SERA PROGNOSTICS, INC. 10%+ Owner 12 Feb 2025
TLIS Talis Biomedical Corp Director, 10%+ Owner 09 Jun 2023
TCRX TScan Therapeutics, Inc. Director 30 Jun 2025
VTVT vTv Therapeutics Inc. Director 03 Sep 2025

Insider Transactions Reported by BAKER BROS. ADVISORS LP:

Sym Company Class Transaction % Value $ * Price $ Shares Shares After Date Ownership
* An asterisk sign (*) next to the price indicates that the price is likely invalid.