Baker Bros. Advisors Lp - Jun 8, 2021 Form 4 Insider Report for Aeglea BioTherapeutics, Inc. (AGLE)

Role
Director
Signature
By: Baker Bros. Advisors LP, Name: Scott L. Lessing, Title: President /s/ Scott L. Lessing
Stock symbol
AGLE
Transactions as of
Jun 8, 2021
Transactions value $
$0
Form type
4
Date filed
6/10/2021, 04:31 PM
Previous filing
May 28, 2021
Next filing
Jun 21, 2021

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction AGLE Non-Qualified Stock Option (right to buy) Award $0 +40K $0.00 40K Jun 8, 2021 Common Stock 40K $6.80 See Footnotes F1, F2, F3, F4, F5
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id Content
F1 40,000 non-qualified stock options ("Stock Options") exercisable solely into common stock ("Common Stock") of Aeglea BioTherapeutics, Inc. (the "Issuer") were granted under the Issuer's 2016 Equity Incentive Plan to Sara Brownstein, a full-time employee of Baker Bros. Advisors LP (the "Adviser"), in her capacity as a director of the Issuer. The Stock Options have a strike price of $6.80 per share, and vest in 12 equal monthly installments beginning on July 8, 2021, or on the date of the next annual meeting of stockholders, if earlier, subject to Sara Brownstein's continued service on the Board of Directors of the Issuer (the "Board").
F2 Sara Brownstein serves on the Board as a representative of Baker Brothers Life Sciences, L.P. ("Life Sciences") and 667, L.P. ("667", and together with Life Sciences, the "Funds").
F3 Pursuant to the policies of the Adviser, Sara Brownstein does not have any right to any of the Issuer's securities issued as part of her service on the Board and the Funds are entitled to receive all of the pecuniary interest in the securities issued. The Funds each own an indirect proportionate pecuniary interest in the Stock Options. Solely as a result of Felix J. Baker's and Julian C. Baker's ownership interests in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the Stock Options (i.e. no direct pecuniary interest).
F4 The Adviser serves as the investment adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds.
F5 Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

Remarks:

Sara Brownstein, a full-time employee of Baker Bros. Advisors LP (the "Adviser"), is a director of Aeglea BioTherapeutics, Inc. (the "Issuer"). By virtue of their representation on the board of directors of the Issuer, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, the reporting persons are deemed directors by deputization of the Issuer.