| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7.2% | $173,095,065 | 10,490,610 | BlackRock, Inc. | 31 Mar 2025 | |||
| FMR LLC | 5.8% | $123,948,417 | 8,536,392 | FMR LLC | 30 Sep 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 3.9% | $82,251,923 | 5,664,733 | Wellington Management Group LLP | 30 Jun 2025 | |||
| Capital Research Global Investors | 3.8% | $90,373,982 | 5,477,211 | Capital Research Global Investors | 31 Dec 2024 | |||
| BAILLIE GIFFORD & CO | 5.6% | -23% | $31,927,897 | -$7,858,384 | 2,198,891 | -20% | BAILLIE GIFFORD & CO | 30 Jun 2025 |
As of 30 Sep 2025, 235 institutional investors reported holding 135,496,666 shares of Denali Therapeutics Inc. - COMMON STOCK (DNLI). This represents 92% of the company’s total 147,179,178 outstanding shares.
The largest institutional shareholders of Denali Therapeutics Inc. - COMMON STOCK (DNLI) together control 74% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 8.4% | 12,289,626 | +2% | 0% | $178,445,369 |
| VANGUARD GROUP INC | 8.1% | 11,992,918 | +1.5% | 0% | $174,137,169 |
| BAILLIE GIFFORD & CO | 7.9% | 11,591,585 | -3% | 0.12% | $168,309,813 |
| FMR LLC | 4.3% | 6,340,316 | -16% | 0% | $92,061,393 |
| T. Rowe Price Investment Management, Inc. | 3.8% | 5,638,567 | +74% | 0.05% | $81,872,000 |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 3.7% | 5,465,037 | -13% | 0.02% | $79,352,339 |
| STATE STREET CORP | 3.7% | 5,464,261 | +21% | 0% | $79,341,070 |
| Temasek Holdings (Private) Ltd | 3.6% | 5,355,832 | 0% | 0.27% | $77,766,681 |
| Capital Research Global Investors | 3.2% | 4,760,858 | +0.22% | 0.01% | $69,127,658 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.1% | 4,568,368 | -31% | 0.01% | $66,333,000 |
| BAKER BROS. ADVISORS LP | 2.5% | 3,731,695 | 0% | 0.39% | $54,184,211 |
| ALLIANCEBERNSTEIN L.P. | 2.4% | 3,520,414 | +12% | 0.02% | $51,116,411 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.4% | 3,466,057 | +9.3% | 0% | $50,335,167 |
| Crestline Management, LP | 2.3% | 3,410,732 | -12% | 85% | $49,523,829 |
| Holocene Advisors, LP | 2.1% | 3,135,712 | +678% | 0.1% | $45,530,538 |
| Point72 Asset Management, L.P. | 1.7% | 2,519,535 | +14% | 0.08% | $36,583,650 |
| DIMENSIONAL FUND ADVISORS LP | 1.6% | 2,357,214 | -2.3% | 0.01% | $34,226,491 |
| GOLDMAN SACHS GROUP INC | 1.5% | 2,163,705 | +16% | 0% | $31,416,997 |
| UBS Group AG | 1.4% | 2,012,353 | +112% | 0.01% | $29,219,365 |
| STEMPOINT CAPITAL LP | 1.2% | 1,734,659 | +145% | 5.1% | $25,187,249 |
| MORGAN STANLEY | 1.1% | 1,689,492 | +29% | 0% | $24,531,439 |
| Fisher Asset Management, LLC | 1.1% | 1,631,496 | +7.6% | 0.01% | $23,689,321 |
| MILLENNIUM MANAGEMENT LLC | 0.89% | 1,307,171 | +45% | 0.01% | $18,980,123 |
| PRINCIPAL FINANCIAL GROUP INC | 0.86% | 1,271,190 | +18% | 0.01% | $18,457,679 |
| NORTHERN TRUST CORP | 0.84% | 1,234,179 | +2.7% | 0% | $17,920,279 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 2,675,442 | $44,171,785 | +$17,587,932 | $16.51 | 20 |
| 2025 Q3 | 135,496,666 | $1,967,413,087 | -$29,612,927 | $14.52 | 235 |
| 2025 Q2 | 137,594,175 | $1,925,023,022 | +$63,128,608 | $13.99 | 228 |
| 2025 Q1 | 132,874,634 | $1,807,534,753 | +$50,388,875 | $13.60 | 219 |
| 2024 Q4 | 127,929,251 | $2,607,162,085 | +$11,750,487 | $20.38 | 222 |
| 2024 Q3 | 126,754,706 | $3,691,746,017 | +$83,332,107 | $29.13 | 215 |
| 2024 Q2 | 123,900,320 | $2,876,933,310 | +$81,781,105 | $23.22 | 202 |
| 2024 Q1 | 122,410,671 | $2,512,114,129 | +$149,691,318 | $20.52 | 208 |
| 2023 Q4 | 115,037,875 | $2,465,293,115 | +$48,272,802 | $21.46 | 208 |
| 2023 Q3 | 108,753,813 | $2,243,639,062 | +$15,314,130 | $20.63 | 194 |
| 2023 Q2 | 107,385,972 | $3,168,950,262 | +$5,897,175 | $29.51 | 198 |
| 2023 Q1 | 108,017,472 | $2,487,976,875 | +$45,585,839 | $23.04 | 198 |
| 2022 Q4 | 106,059,670 | $2,949,511,974 | +$353,989,026 | $27.81 | 195 |
| 2022 Q3 | 92,590,614 | $2,841,171,715 | -$31,157,203 | $30.69 | 192 |
| 2022 Q2 | 92,689,565 | $2,727,755,557 | +$180,988,868 | $29.43 | 177 |
| 2022 Q1 | 86,720,578 | $2,790,606,045 | +$40,452,227 | $32.17 | 177 |
| 2021 Q4 | 85,268,721 | $3,803,185,901 | +$18,535,233 | $44.60 | 204 |
| 2021 Q3 | 82,102,816 | $4,142,844,228 | +$169,589,833 | $50.45 | 205 |
| 2021 Q2 | 77,780,665 | $6,099,806,785 | +$34,022,640 | $78.44 | 204 |
| 2021 Q1 | 77,751,278 | $4,438,997,286 | +$78,721,718 | $57.10 | 213 |
| 2020 Q4 | 66,445,136 | $5,564,771,315 | +$193,800,989 | $83.76 | 199 |
| 2020 Q3 | 82,769,611 | $2,965,793,194 | +$14,445,549 | $35.83 | 168 |
| 2020 Q2 | 82,768,394 | $2,001,309,869 | +$63,425,607 | $24.18 | 142 |
| 2020 Q1 | 80,458,775 | $1,408,929,438 | +$149,773,734 | $17.51 | 127 |
| 2019 Q4 | 70,860,285 | $1,234,391,510 | -$9,532,468 | $17.42 | 107 |
| 2019 Q3 | 71,458,501 | $1,094,801,327 | -$4,573,862 | $15.32 | 112 |
| 2019 Q2 | 63,549,412 | $1,319,252,281 | +$54,502,235 | $20.76 | 113 |
| 2019 Q1 | 61,057,319 | $1,417,761,132 | +$44,297,416 | $23.22 | 113 |
| 2018 Q4 | 68,108,281 | $1,407,070,297 | -$256,309 | $20.66 | 89 |
| 2018 Q3 | 58,053,077 | $1,262,045,654 | +$108,737,022 | $21.74 | 76 |
| 2018 Q2 | 53,287,730 | $812,631,603 | +$13,608,742 | $15.25 | 65 |
| 2018 Q1 | 60,832,830 | $1,196,651,992 | +$60,152,032 | $19.69 | 56 |
| 2017 Q4 | 58,144,510 | $909,309,000 | +$907,640,000 | $15.64 | 45 |