| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 7.2% | $173,095,065 | 10,490,610 | BlackRock, Inc. | 31 Mar 2025 | |||
| FMR LLC | 5.8% | $123,948,417 | 8,536,392 | FMR LLC | 30 Sep 2025 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 3.9% | $82,251,923 | 5,664,733 | Wellington Management Group LLP | 30 Jun 2025 | |||
| Capital Research Global Investors | 3.8% | $90,373,982 | 5,477,211 | Capital Research Global Investors | 31 Dec 2024 | |||
| BAILLIE GIFFORD & CO | 5.6% | -23% | $31,927,897 | -$7,858,384 | 2,198,891 | -20% | BAILLIE GIFFORD & CO | 30 Jun 2025 |
As of 31 Dec 2025, 247 institutional investors reported holding 150,992,112 shares of Denali Therapeutics Inc. - COMMON STOCK (DNLI). This represents 103% of the company’s total 147,179,178 outstanding shares.
The largest institutional shareholders of Denali Therapeutics Inc. - COMMON STOCK (DNLI) together control 81% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8.9% | 13,057,890 | +8.9% | 0% | $215,585,764 |
| BlackRock, Inc. | 8.6% | 12,715,201 | +3.5% | 0% | $209,927,968 |
| BAILLIE GIFFORD & CO | 8.4% | 12,310,889 | +6.2% | 0.17% | $203,252,777 |
| T. Rowe Price Investment Management, Inc. | 4.9% | 7,254,132 | +29% | 0.08% | $119,766,000 |
| Temasek Holdings (Private) Ltd | 4.8% | 7,012,974 | +31% | 0.37% | $115,784,201 |
| STATE STREET CORP | 4.3% | 6,263,371 | +15% | 0% | $103,408,255 |
| FMR LLC | 4.1% | 6,097,211 | -3.8% | 0.01% | $100,664,952 |
| NORGES BANK | 3.5% | 5,119,622 | 0.01% | $84,524,959 | |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3.4% | 4,983,726 | -8.8% | 0.02% | $82,281,317 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.7% | 3,915,951 | -14% | 0.01% | $64,654,000 |
| GOLDMAN SACHS GROUP INC | 2.6% | 3,835,803 | +77% | 0.01% | $63,329,108 |
| BAKER BROS. ADVISORS LP | 2.5% | 3,731,695 | 0% | 0.36% | $61,610,284 |
| Capital Research Global Investors | 2.5% | 3,729,244 | -22% | 0.01% | $61,569,818 |
| ALLIANCEBERNSTEIN L.P. | 2.4% | 3,557,935 | +1.1% | 0.02% | $58,741,507 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.3% | 3,458,131 | -0.23% | 0% | $57,104,172 |
| Holocene Advisors, LP | 2.1% | 3,152,734 | +0.54% | 0.11% | $52,051,638 |
| Crestline Management, LP | 1.9% | 2,810,732 | -18% | 87% | $46,405,185 |
| Fisher Asset Management, LLC | 1.8% | 2,589,403 | +59% | 0.01% | $42,751,042 |
| UBS Group AG | 1.6% | 2,404,704 | +19% | 0.01% | $39,701,663 |
| DIMENSIONAL FUND ADVISORS LP | 1.6% | 2,374,303 | +0.72% | 0.01% | $39,198,394 |
| Aberdeen Group plc | 1.4% | 2,032,967 | +83% | 0.05% | $33,564,285 |
| Casdin Capital, LLC | 1.3% | 1,840,000 | +107% | 1.9% | $30,378,400 |
| Lynx1 Capital Management LP | 1.2% | 1,738,750 | +564% | 5.8% | $28,706,762 |
| Point72 Asset Management, L.P. | 1.2% | 1,700,000 | -33% | 0.04% | $28,067,000 |
| PRINCIPAL FINANCIAL GROUP INC | 1% | 1,524,123 | +20% | 0.01% | $25,163,271 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 150,992,112 | $2,493,130,825 | +$260,851,971 | $16.51 | 247 |
| 2025 Q3 | 135,496,675 | $1,967,413,218 | -$29,612,796 | $14.52 | 236 |
| 2025 Q2 | 137,594,175 | $1,925,023,022 | +$63,128,608 | $13.99 | 228 |
| 2025 Q1 | 132,874,634 | $1,807,534,753 | +$50,388,875 | $13.60 | 219 |
| 2024 Q4 | 127,929,251 | $2,607,162,085 | +$11,750,487 | $20.38 | 222 |
| 2024 Q3 | 126,754,706 | $3,691,746,017 | +$83,332,107 | $29.13 | 215 |
| 2024 Q2 | 123,900,320 | $2,876,933,310 | +$81,781,105 | $23.22 | 202 |
| 2024 Q1 | 122,410,671 | $2,512,114,129 | +$149,691,318 | $20.52 | 208 |
| 2023 Q4 | 115,037,875 | $2,465,293,115 | +$48,272,802 | $21.46 | 208 |
| 2023 Q3 | 108,753,813 | $2,243,639,062 | +$15,314,130 | $20.63 | 194 |
| 2023 Q2 | 107,385,972 | $3,168,950,262 | +$5,897,175 | $29.51 | 198 |
| 2023 Q1 | 108,017,472 | $2,487,976,875 | +$45,585,839 | $23.04 | 198 |
| 2022 Q4 | 106,059,670 | $2,949,511,974 | +$353,989,026 | $27.81 | 195 |
| 2022 Q3 | 92,590,614 | $2,841,171,715 | -$31,157,203 | $30.69 | 192 |
| 2022 Q2 | 92,689,565 | $2,727,755,557 | +$180,988,868 | $29.43 | 177 |
| 2022 Q1 | 86,720,578 | $2,790,606,045 | +$40,452,227 | $32.17 | 177 |
| 2021 Q4 | 85,268,721 | $3,803,185,901 | +$18,535,233 | $44.60 | 204 |
| 2021 Q3 | 82,102,816 | $4,142,844,228 | +$169,589,833 | $50.45 | 205 |
| 2021 Q2 | 77,780,665 | $6,099,806,785 | +$34,022,640 | $78.44 | 204 |
| 2021 Q1 | 77,751,278 | $4,438,997,286 | +$78,721,718 | $57.10 | 213 |
| 2020 Q4 | 66,445,136 | $5,564,771,315 | +$193,800,989 | $83.76 | 199 |
| 2020 Q3 | 82,769,611 | $2,965,793,194 | +$14,445,549 | $35.83 | 168 |
| 2020 Q2 | 82,768,394 | $2,001,309,869 | +$63,425,607 | $24.18 | 142 |
| 2020 Q1 | 80,458,775 | $1,408,929,438 | +$149,773,734 | $17.51 | 127 |
| 2019 Q4 | 70,860,285 | $1,234,391,510 | -$9,532,468 | $17.42 | 107 |
| 2019 Q3 | 71,458,501 | $1,094,801,327 | -$4,573,862 | $15.32 | 112 |
| 2019 Q2 | 63,549,412 | $1,319,252,281 | +$54,502,235 | $20.76 | 113 |
| 2019 Q1 | 61,057,319 | $1,417,761,132 | +$44,297,416 | $23.22 | 113 |
| 2018 Q4 | 68,108,281 | $1,407,070,297 | -$256,309 | $20.66 | 89 |
| 2018 Q3 | 58,053,077 | $1,262,045,654 | +$108,737,022 | $21.74 | 76 |
| 2018 Q2 | 53,287,730 | $812,631,603 | +$13,608,742 | $15.25 | 65 |
| 2018 Q1 | 60,832,830 | $1,196,651,992 | +$60,152,032 | $19.69 | 56 |
| 2017 Q4 | 58,144,510 | $909,309,000 | +$907,640,000 | $15.64 | 45 |