| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 14.3% | $99,960,291 | 11,045,336 | Baker Bros. Advisors LP | 07 Mar 2025 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 10.6% | $34,805,312 | 8,306,757 | T. Rowe Price Associates, Inc. | 30 Sep 2025 | |||
| RTW INVESTMENTS, LP | 8.2% | $26,798,117 | 6,395,732 | RTW Investments, LP | 30 Sep 2025 | |||
| Forbion Capital Fund III Cooperatief U.A. | 6.1% | $38,185,027 | 4,219,340 | Forbion Capital Fund III Cooperatief U.A. | 31 Dec 2024 | |||
| Point72 Asset Management, L.P. | 4.7% | -17% | $15,209,289 | -$3,488,586 | 3,629,902 | -19% | Point72 Asset Management, L.P. | 30 Sep 2025 |
| VANGUARD GROUP INC | 4.77% | $32,542,424 | 3,595,848 | The Vanguard Group | 31 Dec 2024 | |||
| Redmile Group, LLC | 0.7% | -95% | $2,245,077 | -$18,279,751 | 535,818 | -89% | Redmile Group, LLC | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 82,882,156 | $347,530,499 | -$49,961,586 | $4.19 | 160 |
| 2025 Q2 | 80,960,067 | $752,124,138 | -$9,722,609 | $9.29 | 173 |
| 2025 Q1 | 81,976,905 | $799,308,276 | +$36,933,791 | $9.75 | 165 |
| 2024 Q4 | 77,881,821 | $943,217,348 | +$80,774,805 | $12.11 | 155 |
| 2024 Q3 | 69,947,896 | $766,692,674 | -$7,687,757 | $10.96 | 143 |
| 2024 Q2 | 70,902,356 | $638,102,295 | +$37,351,096 | $9 | 148 |
| 2024 Q1 | 67,014,350 | $547,213,173 | +$8,620,113 | $8.17 | 147 |
| 2023 Q4 | 66,033,045 | $556,812,735 | -$40,625,538 | $8.43 | 138 |
| 2023 Q3 | 56,812,005 | $970,921,194 | +$32,501,979 | $17.11 | 126 |
| 2023 Q2 | 54,593,396 | $1,267,069,422 | +$26,630,495 | $23.22 | 139 |
| 2023 Q1 | 53,816,654 | $948,994,808 | +$90,895,078 | $17.66 | 138 |
| 2022 Q4 | 48,204,772 | $1,310,877,449 | +$189,427,869 | $27.2 | 135 |
| 2022 Q3 | 40,775,249 | $704,191,848 | -$8,659,480 | $17.27 | 103 |
| 2022 Q2 | 39,999,317 | $700,208,199 | +$17,983,844 | $17.48 | 98 |
| 2022 Q1 | 39,119,622 | $665,006,692 | -$35,451,893 | $16.98 | 104 |
| 2021 Q4 | 38,825,604 | $1,050,822,879 | +$5,595,187 | $27.1 | 97 |
| 2021 Q3 | 35,350,579 | $1,048,056,990 | +$5,527,419 | $29.64 | 99 |
| 2021 Q2 | 34,863,218 | $1,338,855,937 | -$5,476,278 | $38.42 | 109 |
| 2021 Q1 | 34,665,378 | $1,057,669,955 | +$1,013,258 | $30.51 | 106 |
| 2020 Q4 | 34,484,345 | $1,315,869,430 | +$362,197,042 | $38.15 | 112 |
| 2020 Q3 | 26,602,669 | $611,849,920 | +$25,676,805 | $23.02 | 78 |
| 2020 Q2 | 25,420,897 | $630,933,046 | +$87,691,348 | $24.85 | 75 |
| 2020 Q1 | 22,171,093 | $220,779,588 | -$470,574 | $9.97 | 56 |
| 2019 Q4 | 22,018,833 | $315,719,677 | +$48,171,940 | $14.35 | 61 |
| 2019 Q3 | 18,572,485 | $257,907,605 | -$14,772,415 | $13.9 | 51 |
| 2019 Q2 | 19,565,712 | $286,574,644 | +$6,757,973 | $14.66 | 53 |
| 2019 Q1 | 19,131,429 | $291,385,593 | +$17,749,806 | $15.22 | 53 |
| 2018 Q4 | 18,156,099 | $181,563,000 | +$1,489,969 | $10 | 50 |
| 2018 Q3 | 17,925,571 | $288,599,000 | +$288,599,000 | $16.1 | 54 |