Latest Period
Q1 2026
Security Snapshot
IONIS PHARMACEUTICALS INC - COMMON STOCK (IONS) Institutional Ownership
CUSIP: 462222100
13F Institutional Holders and Ownership History from Q4 2015 to Q2 2026
Institutions Reporting
490
Shares (Excl. Options)
172,535,474
Price
$75.09
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- Security type / class
- Equity / COMMON STOCK
- Symbol
- IONS on Nasdaq
- All holders as of 31 Mar 2026
- Q1 2026
- Total 13F shares
- 172,535,474
- Total 13F value
- $12,955,264,057
- Portfolio coverage rank
- 0.01%
- Share change
- +2,352,688
- Value change
- +$157,000,862
- Number of holders
- 490
- Shares outstanding
- 166,460,189
- SEC-reported price per share
- $79.29
- Insider filing price
- $79.29
Latest holder snapshot
5 signals
Issuer context
Names, identifiers, and filing context for this profile.
3 identity fields
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors
Key facts
- IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK is tracked under CUSIP 462222100.
- 490 institutions reported positions in Q1 2026.
- 5 significant owners is listed from Schedule 13D/13G reporting.
Change
- Holder count moved from 490 to 14 between Q1 2026 and Q2 2026.
- SEC-reported value moved from $12,955,264,057 to $5,314,673.
Research use
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Evidence
Source: SEC Form 13F
Open SEC evidence
Latest holder context comes from 490 institutions filings for Q1 2026.
Security key
462222100
Latest holder period
Q1 2026
13F holders
490
13D/G owners
5
CIK / CUSIP context first
Open Q1 2026 holders
IONS full holder history
IONIS PHARMACEUTICALS INC SEC filings
IONIS PHARMACEUTICALS INC company facts
IONIS PHARMACEUTICALS INC insider transactions
Broader feeds
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 462222100:
13D/G owners
Significant owners
Large-stake holder rows connected to Schedule 13D/G evidence.
Rows
5
Security
IONS
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Capital World Investors | 13% | +15% | $1,592,579,358 | +$242,428,512 | 21,186,369 | +18% | Capital World Investors | 31 Mar 2026 |
| BlackRock, Inc. | 5.7% | $269,638,216 | 9,066,517 | BlackRock, Inc. | 31 Mar 2025 | |||
| VANGUARD CAPITAL MANAGEMENT LLC | 5% | $626,605,926 | 8,344,732 | Vanguard Capital Management | 31 Mar 2026 | |||
| WELLINGTON MANAGEMENT GROUP LLP | 4.3% | $284,413,950 | 6,879,873 | Wellington Management Group LLP | 30 Jun 2025 | |||
| T. Rowe Price Investment Management, Inc. | 3.7% | -32% | $462,974,060 | -$221,675,729 | 6,159,027 | -32% | T. Rowe Price Investment Management, Inc. | 31 Mar 2026 |
As of 31 Mar 2026, 490 institutional investors reported holding 172,535,474 shares of IONIS PHARMACEUTICALS INC - COMMON STOCK (IONS). This represents 104% of the company’s total 166,460,189 outstanding shares.
13F concentration
Top 25 institutional shareholders
Largest 13F positions for this security by reported shares and value.
Top holder share
77%
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 15% | 24,556,637 | +2% | 0.1% | $1,843,957,873 |
| Capital World Investors | 13% | 21,186,369 | +18% | 0.22% | $1,590,884,448 |
| BlackRock, Inc. | 6.3% | 10,442,476 | -1.9% | 0.01% | $784,125,524 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4.7% | 7,808,902 | 0% | 0.03% | $586,370,451 |
| VANGUARD CAPITAL MANAGEMENT LLC | 4.3% | 7,118,330 | 0% | 0.01% | $534,515,400 |
| WELLINGTON MANAGEMENT GROUP LLP | 3.8% | 6,391,816 | +2.1% | 0.09% | $479,961,465 |
| T. Rowe Price Investment Management, Inc. | 3.7% | 6,159,027 | -32% | 0.32% | $462,482,000 |
| TWO SIGMA INVESTMENTS, LP | 3.5% | 5,857,629 | +120% | 0.37% | $439,849,362 |
| STATE STREET CORP | 2.4% | 3,995,564 | +0.52% | 0.01% | $300,026,901 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.4% | 3,984,332 | +27% | 0.02% | $305,196,969 |
| ROYAL BANK OF CANADA | 2.3% | 3,801,815 | +240% | 0.05% | $285,477,000 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.8% | 3,025,251 | +1.3% | 0.03% | $227,167,000 |
| JPMORGAN CHASE & CO | 1.4% | 2,363,567 | +2.6% | 0.01% | $171,405,902 |
| Tweedy, Browne Co LLC | 1.4% | 2,275,625 | -7.7% | 14% | $170,876,681 |
| Artisan Partners Limited Partnership | 1.2% | 2,058,308 | +74% | 0.25% | $154,558,340 |
| BAKER BROS. ADVISORS LP | 1.2% | 2,047,727 | +14% | 0.88% | $153,763,820 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1.2% | 1,979,669 | 0% | 1.8% | $148,653,345 |
| Deep Track Capital, LP | 1.2% | 1,950,000 | +15% | 3% | $146,425,500 |
| Bellevue Group AG | 1.1% | 1,818,665 | -62% | 3.2% | $136,563,555 |
| GOLDMAN SACHS GROUP INC | 1% | 1,699,847 | +99% | 0.02% | $127,641,511 |
| AMERICAN CENTURY COMPANIES INC | 1% | 1,663,803 | +2.9% | 0.06% | $124,935,144 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.95% | 1,583,266 | +2.7% | 0.02% | $118,887,444 |
| FRANKLIN RESOURCES INC | 0.95% | 1,575,023 | +19% | 0.03% | $118,268,500 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.89% | 1,475,632 | +6.3% | 0.02% | $110,805,207 |
| Pictet Asset Management Holding SA | 0.86% | 1,434,995 | +1.2% | 0.11% | $107,076,549 |
Quarter history
Institutional holders across reporting periods
Holder count, reported shares/value, and median price by quarter.
Periods
43
Latest
Q1 2026
Rows shown
1-25 of 43
| Period | 13F Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q2 | 67,029 | $5,314,673 | +$684,038 | $79.29 | 14 |
| 2026 Q1 | 172,535,474 | $12,955,264,057 | +$157,000,862 | $75.09 | 490 |
| 2025 Q4 | 170,226,720 | $13,463,922,363 | +$164,534,797 | $79.11 | 491 |
| 2025 Q3 | 168,163,078 | $11,001,578,263 | +$32,287,787 | $65.42 | 433 |
| 2025 Q2 | 168,850,675 | $6,672,661,270 | +$162,663,034 | $39.51 | 360 |
| 2025 Q1 | 165,860,888 | $5,004,903,523 | +$131,542,151 | $30.17 | 340 |
| 2024 Q4 | 160,366,928 | $5,606,135,985 | +$73,787,817 | $34.96 | 348 |
| 2024 Q3 | 157,127,745 | $6,297,681,566 | +$509,606,602 | $40.06 | 348 |
| 2024 Q2 | 143,207,231 | $6,823,555,846 | +$50,229,849 | $47.66 | 353 |
| 2024 Q1 | 141,857,166 | $6,150,040,836 | -$14,832,123 | $43.35 | 355 |
| 2023 Q4 | 142,480,404 | $7,209,128,718 | +$87,362,106 | $50.59 | 360 |
| 2023 Q3 | 139,863,021 | $6,344,228,254 | +$143,056,679 | $45.36 | 307 |
| 2023 Q2 | 136,544,584 | $5,601,663,585 | +$217,908,412 | $41.03 | 299 |
| 2023 Q1 | 131,377,079 | $4,693,255,222 | +$26,766,918 | $35.74 | 307 |
| 2022 Q4 | 130,693,455 | $4,936,957,475 | +$160,016,480 | $37.77 | 333 |
| 2022 Q3 | 126,410,568 | $5,587,594,025 | -$405,286,321 | $44.23 | 335 |
| 2022 Q2 | 124,531,298 | $4,607,099,903 | +$7,650,768 | $37.02 | 329 |
| 2022 Q1 | 124,797,488 | $4,621,087,277 | +$93,759,462 | $37.04 | 314 |
| 2021 Q4 | 123,208,578 | $3,749,220,496 | +$12,496,745 | $30.43 | 321 |
| 2021 Q3 | 121,685,400 | $4,081,694,378 | -$99,758,435 | $33.54 | 306 |
| 2021 Q2 | 124,355,726 | $4,958,884,573 | +$71,970,644 | $39.89 | 321 |
| 2021 Q1 | 123,194,653 | $5,537,925,756 | +$78,758,790 | $44.96 | 347 |
| 2020 Q4 | 120,098,693 | $6,792,775,467 | +$105,597,041 | $56.54 | 366 |
| 2020 Q3 | 118,507,239 | $5,623,405,509 | -$83,647,855 | $47.45 | 353 |
| 2020 Q2 | 120,124,891 | $7,083,094,879 | +$118,732,834 | $58.96 | 364 |