What does CUSIP 462222100 represent in this 13F holders report?

CUSIP 462222100 is the security identifier for IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK used to aggregate holder disclosures.

How many institutions held IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK in Q4 2021?

321 institutional investors reported IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK for Q4 2021. Use the holders table for investor-level position and value details.

IONIS PHARMACEUTICALS INC - COMMON STOCK (IONS)

CUSIP: 462222100

Q4 2021 13F Holders as of 31 Dec 2021

Type / Class: Equity / COMMON STOCK
Shares outstanding: 166,460,189
Total 13F shares: 123,208,578
Share change: +471,269
Total reported value: $3,749,220,496
Put/Call ratio: 172%
Price per share: $30.43
Number of holders: 321
Value change: +$12,496,745
Number of buys: 141
Number of sells: 148

Security key

462222100

Report period

Q4 2021

Institutions

321

Top holders

IONS full security history Ownership snapshot Full 13F holder table Newer quarter: Q1 2022 Previous quarter: Q3 2021 IONIS PHARMACEUTICALS INC SEC filings IONIS PHARMACEUTICALS INC company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 462222100

Newer quarter: Q1 2022 Previous quarter: Q3 2021

Recent filing periods:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Ownership snapshot

Top shareholders of IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Lead holder

FMR LLC

13D/G signal

—

Evidence rows

Latest as of

30 Sep 2021

13F Lead comparable stake: 13% Showing first 8 of 50 holder rows. Open remaining rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
FMR LLC	13F Company 13F	13%	$710,114,000 21,172,154 shares	—	30 Sep 2021
VANGUARD GROUP INC	13F Company 13F	7.1%	$395,773,000 11,800,009 shares	—	30 Sep 2021
PRICE T ROWE ASSOCIATES INC /MD/	13F Company 13F	7.1%	$393,670,000 11,737,321 shares	—	30 Sep 2021
Bellevue Group AG	13F Company 13F	5.6%	$313,529,000 9,347,926 shares	—	30 Sep 2021
ARK Investment Management LLC	13F Company 13F	5.1%	$285,472,000 8,511,384 shares	—	30 Sep 2021
BlackRock Finance, Inc.	13F Company 13F	4.9%	$272,339,000 8,119,853 shares	—	30 Sep 2021
Clearbridge Investments, LLC	13F Company 13F	4.4%	$245,758,000 7,327,322 shares	—	30 Sep 2021
STATE STREET CORP	13F Company 13F	2.1%	$118,105,000 3,521,314 shares	—	30 Sep 2021

Show 42 additional holder rows in the full holder list

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Camber Capital Management LP	13F Company 13F	1.5%	$83,850,000 2,500,000 shares	—	30 Sep 2021
JPMORGAN CHASE & CO	13F Company 13F	1.5%	$81,044,000 2,416,313 shares	—	30 Sep 2021
GEODE CAPITAL MANAGEMENT, LLC	13F Company 13F	1.1%	$59,458,000 1,772,767 shares	—	30 Sep 2021
FIRST TRUST ADVISORS LP	13F Company 13F	1%	$56,366,000 1,680,549 shares	—	30 Sep 2021
THRIVENT FINANCIAL FOR LUTHERANS	13F Company 13F	0.83%	$46,545,000 1,387,764 shares	—	30 Sep 2021
Rockefeller Capital Management L.P.	13F Company 13F	0.8%	$44,699,000 1,332,780 shares	—	30 Sep 2021
JACOBS LEVY EQUITY MANAGEMENT, INC	13F Company 13F	0.72%	$39,954,000 1,191,236 shares	—	30 Sep 2021
NORGES BANK	13F Company 13F	0.69%	$38,468,000 1,146,918 shares	—	30 Sep 2021
Swedbank AB	13F Company 13F	0.67%	$37,475,550 1,117,339 shares	—	30 Sep 2021
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F Company 13F	0.64%	$35,879,000 1,069,732 shares	—	30 Sep 2021
CITADEL ADVISORS LLC	13F Company 13F	0.63%	$35,213,000 1,049,857 shares	—	30 Sep 2021
WELLS FARGO & COMPANY/MN	13F Company 13F	0.51%	$28,622,000 853,370 shares	—	30 Sep 2021
S.c.a. Candriam	13F Individual 13F	0.44%	$24,361,000 726,359 shares	—	30 Sep 2021
BANK OF AMERICA CORP /DE/	13F Company 13F	0.43%	$23,816,000 710,117 shares	—	30 Sep 2021
Sumitomo Mitsui Trust Group, Inc.	13F Company 13F	0.41%	$22,997,000 685,660 shares	—	30 Sep 2021
Amova Asset Management Americas, Inc.	13F Company 13F	0.41%	$22,623,000 675,301 shares	—	30 Sep 2021
NORTHERN TRUST CORP	13F Company 13F	0.39%	$21,984,000 655,421 shares	—	30 Sep 2021
Nuveen Asset Management, LLC	13F Company 13F	0.38%	$21,079,000 628,476 shares	—	30 Sep 2021
GOLDMAN SACHS GROUP INC	13F Company 13F	0.36%	$20,186,000 601,836 shares	—	30 Sep 2021
Bank of New York Mellon Corp	13F Company 13F	0.34%	$18,801,000 560,565 shares	—	30 Sep 2021
PINNACLE ASSOCIATES LTD	13F Company 13F	0.33%	$18,220,000 543,226 shares	—	30 Sep 2021
MORGAN STANLEY	13F Company 13F	0.3%	$16,701,000 497,936 shares	—	30 Sep 2021
ROYAL BANK OF CANADA	13F Company 13F	0.29%	$16,421,000 489,561 shares	—	30 Sep 2021
Eversept Partners, LP	13F Company 13F	0.27%	$15,109,804 450,501 shares	—	30 Sep 2021
ALTRINSIC GLOBAL ADVISORS LLC	13F Company 13F	0.27%	$14,921,000 444,887 shares	—	30 Sep 2021
TWO SIGMA ADVISERS, LP	13F Company 13F	0.26%	$14,496,000 432,211 shares	—	30 Sep 2021
TD ASSET MANAGEMENT INC	13F Company 13F	0.25%	$14,153,000 421,964 shares	—	30 Sep 2021
Woodline Partners LP	13F Company 13F	0.24%	$13,599,000 405,461 shares	—	30 Sep 2021
NOMURA HOLDINGS INC	13F Company 13F	0.23%	$12,604,000 376,748 shares	—	30 Sep 2021
STIFEL FINANCIAL CORP	13F Company 13F	0.23%	$12,619,000 376,219 shares	—	30 Sep 2021
DIMENSIONAL FUND ADVISORS LP	13F Company 13F	0.21%	$11,935,000 355,839 shares	—	30 Sep 2021
BARCLAYS PLC	13F Company 13F	0.2%	$11,079,000 330,291 shares	—	30 Sep 2021
Tekla Capital Management LLC	13F Company 13F	0.19%	$10,817,000 322,521 shares	—	30 Sep 2021
TWO SIGMA INVESTMENTS, LP	13F Company 13F	0.19%	$10,536,000 314,134 shares	—	30 Sep 2021
DOWLING & YAHNKE LLC	13F Company 13F	0.18%	$10,147,000 302,521 shares	—	30 Sep 2021
BAILLIE GIFFORD & CO	13F Company 13F	0.18%	$10,129,000 302,003 shares	—	30 Sep 2021
RAYMOND JAMES & ASSOCIATES	13F Company 13F	0.18%	$10,111,000 301,449 shares	—	30 Sep 2021
Sicart Associates LLC	13F Company 13F	0.17%	$9,769,000 291,254 shares	—	30 Sep 2021
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM	13F Company 13F	0.17%	$9,664,000 288,128 shares	—	30 Sep 2021
MILLENNIUM MANAGEMENT LLC	13F Company 13F	0.17%	$9,487,000 282,854 shares	—	30 Sep 2021
Swiss National Bank	13F Company 13F	0.17%	$9,388,000 279,900 shares	—	30 Sep 2021
Hudson Bay Capital Management LP	13F Company 13F	0.16%	$8,888,000 265,000 shares	—	30 Sep 2021

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2021

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

321

123,208,578

Rows loaded

322

Investor	Option	Weight %	Change %	Reported value	* Price	Shares	Share Change	Activity	Report Period

* Reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. An asterisk next to the price means the price is likely invalid.

Compare Q4 2021 vs Q3 2021 Across Filers

Q3 2021 holders

306

Q4 2021 holders

321

Holder diff

Investor	Q3 2021 Shares	Q4 2021 Shares	Share Diff	Share Chg %	Q3 2021 value	Q4 2021 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend