What does CUSIP 462222100 represent in this 13F holders report?

CUSIP 462222100 is the security identifier for IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK used to aggregate holder disclosures.

How many institutions held IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK in Q1 2022?

314 institutional investors reported IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK for Q1 2022. Use the holders table for investor-level position and value details.

IONIS PHARMACEUTICALS INC - COMMON STOCK (IONS)

CUSIP: 462222100

Q1 2022 13F Holders as of 31 Mar 2022

Type / Class: Equity / COMMON STOCK
Shares outstanding: 166,460,189
Total 13F shares: 124,797,488
Share change: +2,136,529
Total reported value: $4,621,087,277
Put/Call ratio: 84%
Price per share: $37.04
Number of holders: 314
Value change: +$93,759,462
Number of buys: 147
Number of sells: 151

Security key

462222100

Report period

Q1 2022

Institutions

314

Top holders

IONS full security history Ownership snapshot Full 13F holder table Newer quarter: Q2 2022 Previous quarter: Q4 2021 IONIS PHARMACEUTICALS INC SEC filings IONIS PHARMACEUTICALS INC company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 462222100

Newer quarter: Q2 2022 Previous quarter: Q4 2021

Recent filing periods:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Ownership snapshot

Top shareholders of IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Lead holder

FMR LLC

13D/G signal

—

Evidence rows

Latest as of

31 Dec 2021

13F Lead comparable stake: 13% Showing first 8 of 50 holder rows. Open remaining rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
FMR LLC	13F Company 13F	13%	$644,553,000 21,181,502 shares	—	31 Dec 2021
PRICE T ROWE ASSOCIATES INC /MD/	13F Company 13F	7.5%	$380,079,000 12,490,280 shares	—	31 Dec 2021
VANGUARD GROUP INC	13F Company 13F	7.2%	$365,376,000 12,007,076 shares	—	31 Dec 2021
Bellevue Group AG	13F Company 13F	6.2%	$315,106,000 10,355,123 shares	—	31 Dec 2021
BlackRock Finance, Inc.	13F Company 13F	5.1%	$259,849,000 8,539,282 shares	—	31 Dec 2021
ARK Investment Management LLC	13F Company 13F	4.3%	$215,543,000 7,083,256 shares	—	31 Dec 2021
Clearbridge Investments, LLC	13F Company 13F	3.5%	$179,019,000 5,882,982 shares	—	31 Dec 2021
STATE STREET CORP	13F Company 13F	2.3%	$118,871,000 3,906,375 shares	—	31 Dec 2021

Show 42 additional holder rows in the full holder list

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
GEODE CAPITAL MANAGEMENT, LLC	13F Company 13F	1.1%	$55,541,000 1,825,226 shares	—	31 Dec 2021
FIRST TRUST ADVISORS LP	13F Company 13F	1%	$51,123,000 1,680,012 shares	—	31 Dec 2021
MILLENNIUM MANAGEMENT LLC	13F Company 13F	0.98%	$49,392,000 1,623,138 shares	—	31 Dec 2021
THRIVENT FINANCIAL FOR LUTHERANS	13F Company 13F	0.92%	$46,680,000 1,533,999 shares	—	31 Dec 2021
JACOBS LEVY EQUITY MANAGEMENT, INC	13F Company 13F	0.85%	$42,827,000 1,407,388 shares	—	31 Dec 2021
Camber Capital Management LP	13F Company 13F	0.84%	$42,298,000 1,390,000 shares	—	31 Dec 2021
JPMORGAN CHASE & CO	13F Company 13F	0.76%	$38,605,000 1,268,652 shares	—	31 Dec 2021
CITADEL ADVISORS LLC	13F Company 13F	0.73%	$37,173,000 1,221,571 shares	—	31 Dec 2021
Swedbank AB	13F Company 13F	0.67%	$34,123,533 1,117,339 shares	—	31 Dec 2021
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F Company 13F	0.66%	$33,274,000 1,093,439 shares	—	31 Dec 2021
S.c.a. Candriam	13F Individual 13F	0.56%	$28,502,000 936,635 shares	—	31 Dec 2021
NORGES BANK	13F Company 13F	0.5%	$25,294,000 831,219 shares	—	31 Dec 2021
WELLS FARGO & COMPANY/MN	13F Company 13F	0.49%	$24,678,000 810,966 shares	—	31 Dec 2021
TD ASSET MANAGEMENT INC	13F Company 13F	0.45%	$22,614,000 743,164 shares	—	31 Dec 2021
NORTHERN TRUST CORP	13F Company 13F	0.4%	$20,112,000 660,890 shares	—	31 Dec 2021
Privium Fund Management B.V.	13F Company 13F	0.38%	$19,246,000 630,199 shares	—	31 Dec 2021
BANK OF AMERICA CORP /DE/	13F Company 13F	0.37%	$18,648,000 612,835 shares	—	31 Dec 2021
Sumitomo Mitsui Trust Group, Inc.	13F Company 13F	0.36%	$18,438,000 605,902 shares	—	31 Dec 2021
Amova Asset Management Americas, Inc.	13F Company 13F	0.36%	$17,935,000 605,902 shares	—	31 Dec 2021
BANK OF NOVA SCOTIA	13F Company 13F	0.36%	$18,315,000 601,883 shares	—	31 Dec 2021
TWO SIGMA INVESTMENTS, LP	13F Company 13F	0.36%	$18,102,000 594,885 shares	—	31 Dec 2021
GOLDMAN SACHS GROUP INC	13F Company 13F	0.35%	$17,933,000 589,298 shares	—	31 Dec 2021
Bank of New York Mellon Corp	13F Company 13F	0.33%	$16,937,000 556,576 shares	—	31 Dec 2021
PINNACLE ASSOCIATES LTD	13F Company 13F	0.33%	$16,464,000 541,044 shares	—	31 Dec 2021
TWO SIGMA ADVISERS, LP	13F Company 13F	0.3%	$15,136,000 497,411 shares	—	31 Dec 2021
ROYAL BANK OF CANADA	13F Company 13F	0.29%	$14,626,000 480,648 shares	—	31 Dec 2021
MORGAN STANLEY	13F Company 13F	0.28%	$14,146,000 464,885 shares	—	31 Dec 2021
Woodline Partners LP	13F Company 13F	0.25%	$12,521,000 411,454 shares	—	31 Dec 2021
ALTRINSIC GLOBAL ADVISORS LLC	13F Company 13F	0.24%	$12,153,000 399,392 shares	—	31 Dec 2021
DIMENSIONAL FUND ADVISORS LP	13F Company 13F	0.23%	$11,767,000 386,691 shares	—	31 Dec 2021
Eversept Partners, LP	13F Company 13F	0.23%	$11,709,129 384,789 shares	—	31 Dec 2021
NOMURA HOLDINGS INC	13F Company 13F	0.22%	$11,348,000 372,480 shares	—	31 Dec 2021
STIFEL FINANCIAL CORP	13F Company 13F	0.22%	$10,892,000 357,948 shares	—	31 Dec 2021
INTERNATIONAL BIOTECHNOLOGY TRUST PLC	13F Company 13F	0.21%	$10,805,000 355,088 shares	—	31 Dec 2021
Nuveen Asset Management, LLC	13F Company 13F	0.21%	$10,696,000 351,476 shares	—	31 Dec 2021
BARCLAYS PLC	13F Company 13F	0.2%	$10,039,000 329,938 shares	—	31 Dec 2021
Sio Capital Management, LLC	13F Company 13F	0.19%	$9,816,000 322,566 shares	—	31 Dec 2021
BAILLIE GIFFORD & CO	13F Company 13F	0.19%	$9,611,000 315,820 shares	—	31 Dec 2021
BNP PARIBAS FINANCIAL MARKETS	13F Company 13F	0.18%	$9,319,279 306,253 shares	—	31 Dec 2021
Hudson Bay Capital Management LP	13F Company 13F	0.18%	$9,281,000 305,000 shares	—	31 Dec 2021
DOWLING & YAHNKE LLC	13F Company 13F	0.18%	$9,203,000 302,421 shares	—	31 Dec 2021
NATIXIS	13F Company 13F	0.18%	$9,153,000 300,797 shares	—	31 Dec 2021

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q1 2022

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

314

124,797,488

Rows loaded

315

Investor	Option	Weight %	Change %	Reported value	* Price	Shares	Share Change	Activity	Report Period

* Reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. An asterisk next to the price means the price is likely invalid.

Compare Q1 2022 vs Q4 2021 Across Filers

Q4 2021 holders

321

Q1 2022 holders

314

Holder diff

-7

Investor	Q4 2021 Shares	Q1 2022 Shares	Share Diff	Share Chg %	Q4 2021 value	Q1 2022 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend