What does CUSIP 462222100 represent in this 13F holders report?

CUSIP 462222100 is the security identifier for IONS - IONIS PHARMACEUTICALS INC - Common Stock used to aggregate holder disclosures.

How many institutions held IONS - IONIS PHARMACEUTICALS INC - Common Stock in Q4 2018?

313 institutional investors reported IONS - IONIS PHARMACEUTICALS INC - Common Stock for Q4 2018. Use the holders table for investor-level position and value details.

IONIS PHARMACEUTICALS INC - Common Stock (IONS)

CUSIP: 462222100

Q4 2018 13F Holders as of 31 Dec 2018

Type / Class: Equity / Common Stock
Shares outstanding: 162,643,196
Total 13F shares: 117,697,799
Share change: -796,130
Total reported value: $6,364,862,646
Put/Call ratio: 162%
Price per share: $54.06
Number of holders: 313
Value change: -$40,799,223
Number of buys: 117
Number of sells: 154

Quarterly Holders Quick Answers

What is CUSIP 462222100?
CUSIP 462222100 identifies IONS - IONIS PHARMACEUTICALS INC - Common Stock in SEC institutional holdings data.

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Newer quarter: Q1 2019
Previous quarter: Q3 2018

Recent filing periods for CUSIP 462222100:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Top shareholders of IONS - IONIS PHARMACEUTICALS INC - Common Stock (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
FMR LLC	13F	Company	13%	20,463,838	$1,055,525,000	—	30 Sep 2018	13F
VANGUARD GROUP INC	13F	Company	6.8%	11,091,298	$572,089,000	—	30 Sep 2018	13F
Clearbridge Investments, LLC	13F	Company	6.3%	10,236,939	$528,021,000	—	30 Sep 2018	13F
WELLINGTON MANAGEMENT GROUP LLP	13F	Company	5.7%	9,295,165	$479,443,000	—	30 Sep 2018	13F
BAILLIE GIFFORD & CO	13F	Company	5.5%	8,958,113	$462,060,000	—	30 Sep 2018	13F
BB BIOTECH AG	13F	Company	5.3%	8,666,334	$447,010,000	—	30 Sep 2018	13F
BlackRock Finance, Inc.	13F	Company	4.6%	7,463,257	$384,955,000	—	30 Sep 2018	13F
WADDELL & REED FINANCIAL INC	13F	Company	2.4%	3,832,711	$197,691,000	—	30 Sep 2018	13F
STATE STREET CORP	13F	Company	1.9%	3,014,716	$155,501,000	—	30 Sep 2018	13F
FIRST TRUST ADVISORS LP	13F	Company	1.3%	2,125,724	$109,645,000	—	30 Sep 2018	13F
OppenheimerFunds, Inc.	13F	Company	1.3%	2,067,600	$106,646,000	—	30 Sep 2018	13F
GOLDMAN SACHS GROUP INC	13F	Company	0.98%	1,595,475	$82,295,000	—	30 Sep 2018	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	0.77%	1,259,281	$64,953,000	—	30 Sep 2018	13F
NORGES BANK	13F	Company	0.74%	1,203,089	$62,055,000	—	30 Sep 2018	13F
AMERICAN CENTURY COMPANIES INC	13F	Company	0.73%	1,190,719	$61,417,000	—	30 Sep 2018	13F
WELLS FARGO & COMPANY/MN	13F	Company	0.72%	1,165,267	$60,104,000	—	30 Sep 2018	13F
PRICE T ROWE ASSOCIATES INC /MD/	13F	Company	0.67%	1,094,536	$56,456,000	—	30 Sep 2018	13F
PINNACLE ASSOCIATES LTD	13F	Company	0.6%	970,065	$50,036,000	—	30 Sep 2018	13F
RAYMOND JAMES & ASSOCIATES	13F	Company	0.5%	812,368	$41,902,000	—	30 Sep 2018	13F
BANK OF AMERICA CORP /DE/	13F	Company	0.47%	759,214	$39,160,000	—	30 Sep 2018	13F
DOWLING & YAHNKE LLC	13F	Company	0.42%	675,478	$34,841,000	—	30 Sep 2018	13F
NORTHERN TRUST CORP	13F	Company	0.39%	640,212	$33,023,000	—	30 Sep 2018	13F
STIFEL FINANCIAL CORP	13F	Company	0.37%	606,027	$31,264,000	—	30 Sep 2018	13F
TOCQUEVILLE ASSET MANAGEMENT L.P.	13F	Company	0.36%	587,662	$30,312,000	—	30 Sep 2018	13F
CREDIT SUISSE AG/	13F	Company	0.34%	556,496	$28,705,000	—	30 Sep 2018	13F
TWO SIGMA INVESTMENTS, LP	13F	Company	0.33%	539,669	$27,836,000	—	30 Sep 2018	13F
Motley Fool Wealth Management, LLC	13F	Company	0.33%	536,670	$27,681,000	—	30 Sep 2018	13F
Bank of New York Mellon Corp	13F	Company	0.32%	527,902	$27,229,000	—	30 Sep 2018	13F
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F	Company	0.32%	525,755	$27,119,000	—	30 Sep 2018	13F
ALTRINSIC GLOBAL ADVISORS LLC	13F	Company	0.32%	524,218	$27,039,000	—	30 Sep 2018	13F
Sicart Associates LLC	13F	Company	0.32%	523,844	$27,020,000	—	30 Sep 2018	13F
BVF INC/IL	13F	Company	0.32%	520,000	$26,822,000	—	30 Sep 2018	13F
Fiera Capital Corp	13F	Company	0.3%	492,213	$25,388,000	—	30 Sep 2018	13F
First Light Asset Management, LLC	13F	Company	0.3%	492,140	$25,385,000	—	30 Sep 2018	13F
FRANKLIN RESOURCES INC	13F	Company	0.3%	490,574	$25,303,000	—	30 Sep 2018	13F
ROYAL BANK OF CANADA	13F	Company	0.28%	459,627	$23,708,000	—	30 Sep 2018	13F
CANADA PENSION PLAN INVESTMENT BOARD	13F	Company	0.24%	391,800	$20,209,000	—	30 Sep 2018	13F
PDT Partners, LLC	13F	Company	0.24%	391,337	$20,185,000	—	30 Sep 2018	13F
Mitsubishi UFJ Trust & Banking Corp	13F	Company	0.23%	379,410	$19,570,000	—	30 Sep 2018	13F
SCOUT INVESTMENTS, INC.	13F	Company	0.23%	369,985	$19,084,000	—	30 Sep 2018	13F
AXA S.A.	13F	Company	0.22%	364,820	$18,817,000	—	30 Sep 2018	13F
Bellevue Group AG	13F	Company	0.19%	310,536	$16,017,000	—	30 Sep 2018	13F
TWO SIGMA ADVISERS, LP	13F	Company	0.19%	308,211	$15,898,000	—	30 Sep 2018	13F
TIAA CREF INVESTMENT MANAGEMENT LLC	13F	Company	0.18%	297,403	$15,340,000	—	30 Sep 2018	13F
NEW YORK STATE COMMON RETIREMENT FUND	13F	Company	0.18%	294,661	$15,199,000	—	30 Sep 2018	13F
ROTHSCHILD & CO ASSET MANAGEMENT US INC.	13F	Company	0.17%	275,921	$14,232,000	—	30 Sep 2018	13F
PEREGRINE CAPITAL MANAGEMENT LLC	13F	Company	0.17%	269,382	$13,895,000	—	30 Sep 2018	13F
DIMENSIONAL FUND ADVISORS LP	13F	Company	0.17%	268,699	$13,860,000	—	30 Sep 2018	13F
CARILLON TOWER ADVISERS, INC.	13F	Company	0.15%	249,600	$12,874,000	—	30 Sep 2018	13F
BLB&B Advisors, LLC	13F	Company	0.15%	249,546	$12,872,000	—	30 Sep 2018	13F

Institutional Holders of IONIS PHARMACEUTICALS INC - Common Stock (IONS) as of Q4 2018

As of 31 Dec 2018, IONIS PHARMACEUTICALS INC - Common Stock (IONS) was held by 313 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 117,697,799 shares. The largest 10 holders included FMR LLC, Vanguard Group Inc, Clearbridge Investments, LLC, BAILLIE GIFFORD & CO, BB BIOTECH AG, BlackRock Inc., WELLINGTON MANAGEMENT GROUP LLP, WADDELL & REED FINANCIAL INC, STATE STREET CORP, and FIRST TRUST ADVISORS LP. This page lists 313 institutional shareholders reporting positions in this security for the Q4 2018 filing period.

Investor	Option	Weight %	Change %	Value $	* Price	Shares	Share Change	Activity	Report Period

Compare Q4 2018 vs Q3 2018 Across Filers

Q3 2018 holders

309

Q4 2018 holders

313

Holder diff

Investor	Q3 2018 Shares	Q4 2018 Shares	Share Diff	Share Chg %	Q3 2018 Value $	Q4 2018 Value $	Value Diff $	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.