What does CUSIP 462222100 represent in this 13F holders report?

CUSIP 462222100 is the security identifier for IONS - IONIS PHARMACEUTICALS INC - Common Stock used to aggregate holder disclosures.

How many institutions held IONS - IONIS PHARMACEUTICALS INC - Common Stock in Q4 2020?

366 institutional investors reported IONS - IONIS PHARMACEUTICALS INC - Common Stock for Q4 2020. Use the holders table for investor-level position and value details.

IONIS PHARMACEUTICALS INC - Common Stock (IONS)

CUSIP: 462222100

Q4 2020 13F Holders as of 31 Dec 2020

Type / Class: Equity / Common Stock
Shares outstanding: 165,242,218
Total 13F shares: 120,098,693
Share change: +1,570,087
Total reported value: $6,792,775,467
Put/Call ratio: 44%
Price per share: $56.54
Number of holders: 366
Value change: +$105,597,041
Number of buys: 165
Number of sells: 155

Quarterly Holders Quick Answers

What is CUSIP 462222100?
CUSIP 462222100 identifies IONS - IONIS PHARMACEUTICALS INC - Common Stock in SEC institutional holdings data.

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Explore More Reporting Periods

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Newer quarter: Q1 2021
Previous quarter: Q3 2020

Recent filing periods for CUSIP 462222100:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Top shareholders of IONS - IONIS PHARMACEUTICALS INC - Common Stock (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
FMR LLC	13F	Company	13%	20,866,952	$990,137,000	—	30 Sep 2020	13F
VANGUARD GROUP INC	13F	Company	7.3%	11,990,030	$568,926,000	—	30 Sep 2020	13F
PRICE T ROWE ASSOCIATES INC /MD/	13F	Company	6.5%	10,732,025	$509,235,000	—	30 Sep 2020	13F
Bellevue Group AG	13F	Company	5.3%	8,716,270	$413,588,000	—	30 Sep 2020	13F
BlackRock Finance, Inc.	13F	Company	5.1%	8,465,407	$401,681,000	—	30 Sep 2020	13F
Clearbridge Investments, LLC	13F	Company	4.4%	7,273,365	$345,121,000	—	30 Sep 2020	13F
BAILLIE GIFFORD & CO	13F	Company	3%	4,920,843	$233,493,000	—	30 Sep 2020	13F
STATE STREET CORP	13F	Company	2.2%	3,554,894	$168,680,000	—	30 Sep 2020	13F
Invesco Ltd.	13F	Company	1.6%	2,571,641	$122,024,000	—	30 Sep 2020	13F
WADDELL & REED FINANCIAL INC	13F	Company	1.3%	2,150,770	$102,054,000	—	30 Sep 2020	13F
CITADEL ADVISORS LLC	13F	Company	1.2%	1,969,513	$93,453,000	—	30 Sep 2020	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	0.96%	1,590,290	$75,394,000	—	30 Sep 2020	13F
RENAISSANCE TECHNOLOGIES LLC	13F	Company	0.89%	1,467,167	$69,617,000	—	30 Sep 2020	13F
FIRST TRUST ADVISORS LP	13F	Company	0.85%	1,397,713	$66,321,000	—	30 Sep 2020	13F
AMERICAN CENTURY COMPANIES INC	13F	Company	0.81%	1,335,714	$63,379,000	—	30 Sep 2020	13F
TWO SIGMA ADVISERS, LP	13F	Company	0.66%	1,090,111	$51,726,000	—	30 Sep 2020	13F
TWO SIGMA INVESTMENTS, LP	13F	Company	0.58%	952,136	$45,179,000	—	30 Sep 2020	13F
WELLS FARGO & COMPANY/MN	13F	Company	0.56%	918,027	$43,561,000	—	30 Sep 2020	13F
WELLINGTON MANAGEMENT GROUP LLP	13F	Company	0.53%	868,993	$41,234,000	—	30 Sep 2020	13F
NORGES BANK	13F	Company	0.52%	863,716	$40,983,000	—	30 Sep 2020	13F
BANK OF AMERICA CORP /DE/	13F	Company	0.52%	856,822	$40,656,000	—	30 Sep 2020	13F
NORTHERN TRUST CORP	13F	Company	0.5%	831,536	$39,457,000	—	30 Sep 2020	13F
JPMORGAN CHASE & CO	13F	Company	0.44%	727,929	$35,290,000	—	30 Sep 2020	13F
Sumitomo Mitsui Trust Group, Inc.	13F	Company	0.45%	738,817	$35,057,000	—	30 Sep 2020	13F
BVF INC/IL	13F	Company	0.44%	735,055	$34,878,000	—	30 Sep 2020	13F
Rockefeller Capital Management L.P.	13F	Company	0.43%	717,125	$34,026,000	—	30 Sep 2020	13F
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F	Company	0.41%	681,204	$32,324,000	—	30 Sep 2020	13F
GOLDMAN SACHS GROUP INC	13F	Company	0.36%	590,060	$27,998,000	—	30 Sep 2020	13F
PINNACLE ASSOCIATES LTD	13F	Company	0.35%	582,869	$27,657,000	—	30 Sep 2020	13F
DOWLING & YAHNKE LLC	13F	Company	0.35%	575,478	$27,306,000	—	30 Sep 2020	13F
Bank of New York Mellon Corp	13F	Company	0.33%	547,355	$25,972,000	—	30 Sep 2020	13F
Swiss National Bank	13F	Company	0.31%	515,459	$24,459,000	—	30 Sep 2020	13F
ARK Investment Management LLC	13F	Company	0.3%	502,560	$23,846,000	—	30 Sep 2020	13F
DIMENSIONAL FUND ADVISORS LP	13F	Company	0.27%	451,318	$21,420,000	—	30 Sep 2020	13F
Legal & General Group Plc	13F	Company	0.26%	434,505	$20,617,000	—	30 Sep 2020	13F
Nuveen Asset Management, LLC	13F	Company	0.26%	426,898	$20,256,000	—	30 Sep 2020	13F
Sicart Associates LLC	13F	Company	0.25%	418,295	$19,848,000	—	30 Sep 2020	13F
Mitsubishi UFJ Trust & Banking Corp	13F	Company	0.24%	391,106	$18,558,000	—	30 Sep 2020	13F
RAYMOND JAMES & ASSOCIATES	13F	Company	0.22%	362,429	$17,197,000	—	30 Sep 2020	13F
STIFEL FINANCIAL CORP	13F	Company	0.22%	361,178	$17,138,000	—	30 Sep 2020	13F
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	13F	Company	0.21%	348,899	$16,555,258	—	30 Sep 2020	13F
ALTRINSIC GLOBAL ADVISORS LLC	13F	Company	0.21%	343,952	$16,320,000	—	30 Sep 2020	13F
BANK OF MONTREAL /CAN/	13F	Company	0.2%	334,172	$15,137,000	—	30 Sep 2020	13F
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM	13F	Company	0.18%	297,983	$14,139,000	—	30 Sep 2020	13F
Point72 Asset Management, L.P.	13F	Company	0.17%	288,492	$13,689,000	—	30 Sep 2020	13F
TD ASSET MANAGEMENT INC	13F	Company	0.17%	279,647	$13,269,000	—	30 Sep 2020	13F
SUSQUEHANNA INTERNATIONAL GROUP, LLP	13F	Company	0.17%	277,886	$13,186,000	—	30 Sep 2020	13F
TOCQUEVILLE ASSET MANAGEMENT L.P.	13F	Company	0.17%	275,832	$13,088,000	—	30 Sep 2020	13F
DEUTSCHE BANK AG\	13F	Company	0.16%	259,617	$12,320,000	—	30 Sep 2020	13F
S.c.a. Candriam	13F	Individual	0.15%	253,700	$12,038,000	—	30 Sep 2020	13F

Institutional Holders of IONIS PHARMACEUTICALS INC - Common Stock (IONS) as of Q4 2020

As of 31 Dec 2020, IONIS PHARMACEUTICALS INC - Common Stock (IONS) was held by 366 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 120,098,693 shares. The largest 10 holders included FMR LLC, PRICE T ROWE ASSOCIATES INC /MD/, VANGUARD GROUP INC, BlackRock Inc., Bellevue Group AG, Clearbridge Investments, LLC, STATE STREET CORP, Invesco Ltd., ARK Investment Management LLC, and WADDELL & REED FINANCIAL INC. This page lists 367 institutional shareholders reporting positions in this security for the Q4 2020 filing period.

Investor	Option	Weight %	Change %	Value $	* Price	Shares	Share Change	Activity	Report Period

Compare Q4 2020 vs Q3 2020 Across Filers

Q3 2020 holders

353

Q4 2020 holders

366

Holder diff

Investor	Q3 2020 Shares	Q4 2020 Shares	Share Diff	Share Chg %	Q3 2020 Value $	Q4 2020 Value $	Value Diff $	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.