RHYTHM PHARMACEUTICALS, INC. - Common Stock, $0.001 par value per share (RYTM)
CUSIP: 76243J105
Q4 2025 13F Holders as of 31 Dec 2025
- Type / Class
- Equity / Common Stock, $0.001 par value per share
- Shares outstanding
- 69,012,275
- Total 13F shares
- 72,869,425
- Share change
- +1,953,215
- Total reported value
- $7,800,473,192
- Put/Call ratio
- 73%
- Price per share
- $107.04
- Number of holders
- 277
- Value change
- +$220,702,143
- Number of buys
- 154
- Number of sells
- 128
Quarterly Holders Quick Answers
What is CUSIP 76243J105?
CUSIP 76243J105 identifies RYTM - RHYTHM PHARMACEUTICALS, INC. - Common Stock, $0.001 par value per share in SEC institutional holdings data.
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Recent filing periods for CUSIP 76243J105:
Top shareholders of RYTM - RHYTHM PHARMACEUTICALS, INC. - Common Stock, $0.001 par value per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. |
13D/G
13F
|
Company |
9.9%
|
6,666,837
|
$662,816,935 | +$109,906,623 | 31 Dec 2025 | |
| BlackRock, Inc. |
13F
13D/G
|
Company |
6.9%
from 13D/G
|
6,302,215
|
$636,460,694 | — | 30 Sep 2025 | |
| BAKER BROS. ADVISORS LP |
13F
13D/G
|
Company |
8.9%
from 13D/G
|
5,604,483
|
$565,996,738 | — | 30 Sep 2025 | |
| VANGUARD GROUP INC |
13F
|
Company |
7.2%
|
4,996,427
|
$504,589,163 | — | 30 Sep 2025 | |
| PRIMECAP MANAGEMENT CO/CA/ |
13F
13D/G
|
Company |
5.2%
from 13D/G
|
4,262,859
|
$430,506,130 | — | 30 Sep 2025 | |
| NEA Management Company, LLC |
13F
|
Company |
4.2%
|
2,909,956
|
$293,876,456 | — | 30 Sep 2025 | |
| PERCEPTIVE ADVISORS LLC |
13F
|
Company |
3.5%
|
2,438,969
|
$246,311,479 | — | 30 Sep 2025 | |
| FMR LLC |
13F
|
Company |
3.1%
|
2,145,183
|
$216,642,009 | — | 30 Sep 2025 | |
| STATE STREET CORP |
13F
|
Company |
2.9%
|
2,028,651
|
$204,873,464 | — | 30 Sep 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
13D/G
|
Company · THE GOLDMAN SACHS GROUP, INC. |
3%
from 13D/G
|
1,893,663
|
$191,241,026 | — | 30 Sep 2025 | |
| FEDERATED HERMES, INC. |
13F
|
Company |
2.5%
|
1,727,885
|
$174,499,106 | — | 30 Sep 2025 | |
| PRICE T ROWE ASSOCIATES INC /MD/ |
13F
|
Company |
2%
|
1,399,897
|
$141,377,000 | — | 30 Sep 2025 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
13F
|
Company |
2%
|
1,383,775
|
$139,747,437 | — | 30 Sep 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
2%
|
1,362,829
|
$137,654,057 | — | 30 Sep 2025 | |
| Polar Capital Holdings Plc |
13F
|
Company |
1.8%
|
1,244,932
|
$125,725,683 | — | 30 Sep 2025 | |
| JPMORGAN CHASE & CO |
13F
|
Company |
1.7%
|
1,188,069
|
$119,983,088 | — | 30 Sep 2025 | |
| JANUS HENDERSON GROUP PLC |
13F
|
Company |
1.7%
|
1,160,887
|
$117,237,978 | — | 30 Sep 2025 | |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
13F
|
Company |
1.5%
|
1,069,004
|
$107,958,714 | — | 30 Sep 2025 | |
| ALKEON CAPITAL MANAGEMENT LLC |
13F
|
Company |
1.5%
|
1,017,700
|
$102,777,523 | — | 30 Sep 2025 | |
| ALLIANCEBERNSTEIN L.P. |
13F
|
Company |
1.4%
|
979,682
|
$98,938,085 | — | 30 Sep 2025 | |
| Checkpoint Capital L.P. |
13F
|
Company |
1.1%
|
763,707
|
$77,126,770 | — | 30 Sep 2025 | |
| Rock Springs Capital Management LP |
13F
|
Company |
1%
|
717,102
|
$72,420,131 | — | 30 Sep 2025 | |
| Pictet Asset Management Holding SA |
13F
|
Company |
0.99%
|
683,017
|
$68,952,135 | — | 30 Sep 2025 | |
| Capital Research Global Investors |
13F
|
Company |
0.87%
|
598,247
|
$60,416,965 | — | 30 Sep 2025 | |
| Woodline Partners LP |
13F
|
Company |
0.84%
|
580,183
|
$58,592,681 | — | 30 Sep 2025 | |
| LORD, ABBETT & CO. LLC |
13F
|
Company |
0.83%
|
575,984
|
$58,169,000 | — | 30 Sep 2025 | |
| FRANKLIN RESOURCES INC |
13F
|
Company |
0.82%
|
567,782
|
$57,340,305 | — | 30 Sep 2025 | |
| RENAISSANCE TECHNOLOGIES LLC |
13F
|
Company |
0.79%
|
546,593
|
$55,200,427 | — | 30 Sep 2025 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
13F
|
Company |
0.79%
|
544,000
|
$54,938,560 | — | 30 Sep 2025 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.76%
|
527,922
|
$53,314,843 | — | 30 Sep 2025 | |
| LOOMIS SAYLES & CO L P |
13F
|
Company |
0.76%
|
527,439
|
$53,266,065 | — | 30 Sep 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.74%
|
510,906
|
$51,596,397 | — | 30 Sep 2025 | |
| Siren, L.L.C. |
13F
|
Individual |
0.72%
|
499,975
|
$50,492,475 | — | 30 Sep 2025 | |
| Clearbridge Investments, LLC |
13F
|
Company |
0.7%
|
484,732
|
$48,953,090 | — | 30 Sep 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.67%
|
465,190
|
$46,979,603 | — | 30 Sep 2025 | |
| Opaleye Management Inc. |
13F
|
Company |
0.67%
|
461,700
|
$46,627,083 | — | 30 Sep 2025 | |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
13F
|
Company |
0.63%
|
437,472
|
$44,180,298 | — | 30 Sep 2025 | |
| UBS Group AG |
13F
|
Company |
0.61%
|
420,336
|
$42,449,733 | — | 30 Sep 2025 | |
| JENNISON ASSOCIATES LLC |
13F
|
Company |
0.6%
|
411,550
|
$41,562,435 | — | 30 Sep 2025 | |
| SILVERARC CAPITAL MANAGEMENT, LLC |
13F
|
Company |
0.54%
|
369,996
|
$37,365,896 | — | 30 Sep 2025 | |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
13F
|
Company |
0.53%
|
368,263
|
$37,190,880 | — | 30 Sep 2025 | |
| BALYASNY ASSET MANAGEMENT L.P. |
13F
|
Company |
0.51%
|
350,008
|
$35,347,308 | — | 30 Sep 2025 | |
| Sofinnova Investments, Inc. |
13F
|
Company |
0.36%
|
246,966
|
$24,941,096 | — | 30 Sep 2025 | |
| Qube Research & Technologies Ltd |
13F
|
Company |
0.35%
|
238,819
|
$24,118,331 | — | 30 Sep 2025 | |
| Artisan Partners Limited Partnership |
13F
|
Company |
0.34%
|
236,841
|
$23,918,573 | — | 30 Sep 2025 | |
| Hood River Capital Management LLC |
13F
|
Company |
0.34%
|
235,836
|
$23,817,078 | — | 30 Sep 2025 | |
| BANK OF AMERICA CORP /DE/ |
13F
|
Company |
0.34%
|
233,150
|
$23,545,819 | — | 30 Sep 2025 | |
| Assenagon Asset Management S.A. |
13F
|
Company |
0.32%
|
224,128
|
$22,634,687 | — | 30 Sep 2025 | |
| BNP PARIBAS FINANCIAL MARKETS |
13F
|
Company |
0.32%
|
223,681
|
$22,589,544 | — | 30 Sep 2025 | |
| S.c.a. Candriam |
13F
|
Individual |
0.32%
|
221,863
|
$22,405,944 | — | 30 Sep 2025 |
Institutional Holders of RHYTHM PHARMACEUTICALS, INC. - Common Stock, $0.001 par value per share (RYTM) as of Q4 2025
As of 31 Dec 2025,
RHYTHM PHARMACEUTICALS, INC. - Common Stock, $0.001 par value per share (RYTM) was held by
277 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
72,869,425 shares.
The largest 10 holders included
RA CAPITAL MANAGEMENT, L.P., BlackRock, Inc., VANGUARD GROUP INC, BAKER BROS. ADVISORS LP, PRIMECAP MANAGEMENT CO/CA/, NEA Management Company, LLC, PERCEPTIVE ADVISORS LLC, STATE STREET CORP, GOLDMAN SACHS GROUP INC, and FMR LLC.
This page lists
277
institutional shareholders reporting positions in this security
for the Q4 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
263
Q4 2025 holders
277
Holder diff
14
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 Value $ | Q4 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.