Latest Period
Q1 2026
Security Snapshot
Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) Institutional Ownership
CUSIP: 81734D104
13F Institutional Holders and Ownership History from Q4 2024 to Q1 2026
Institutions Reporting
124
Shares (Excl. Options)
45,721,668
Price
$24.03
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- Security type / class
- Equity / Common Stock, $0.001 par value per share
- Symbol
- SEPN on Nasdaq
- All holders as of 31 Mar 2026
- Q1 2026
- Total 13F shares
- 45,721,668
- Total 13F value
- $1,098,633,508
- Portfolio coverage rank
- 0%
- Share change
- +69,126
- Value change
- -$3,059,970
- Number of holders
- 124
- Shares outstanding
- 45,283,737
- SEC-reported price per share
- $24.84
- Insider filing price
- $24.84
Latest holder snapshot
5 signals
Issuer context
Names, identifiers, and filing context for this profile.
3 identity fields
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors
Key facts
- SEPN - Septerna, Inc. - Common Stock, $0.001 par value per share is tracked under CUSIP 81734D104.
- 124 institutions reported positions in Q1 2026.
- 3 significant owners is listed from Schedule 13D/13G reporting.
Change
- Holder count moved from 123 to 124 between Q4 2025 and Q1 2026.
- SEC-reported value moved from $1,270,965,588 to $1,098,633,508.
Research use
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Evidence
Source: SEC Form 13F
Open SEC evidence
Latest holder context comes from 124 institutions filings for Q1 2026.
Security key
81734D104
Latest holder period
Q1 2026
13F holders
124
13D/G owners
3
CIK / CUSIP context first
Open Q1 2026 holders
SEPN full holder history
Septerna, Inc. SEC filings
Septerna, Inc. company facts
Septerna, Inc. insider transactions
Broader feeds
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 81734D104:
13D/G owners
Significant owners
Large-stake holder rows connected to Schedule 13D/G evidence.
Rows
3
Security
SEPN
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Third Rock Ventures V, L.P. | 14% | 0% | $43,509,137 | 6,215,591 | 0% | Third Rock Ventures V, L.P. | 31 Mar 2025 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 10% | +49% | $31,361,201 | +$10,346,049 | 4,659,911 | +49% | DRIEHAUS CAPITAL MANAGEMENT LLC | 31 May 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 3.8% | -61% | $42,813,056 | -$66,562,509 | 1,720,782 | -61% | BVF PARTNERS L P/IL | 31 Dec 2025 |
As of 31 Mar 2026, 124 institutional investors reported holding 45,721,668 shares of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN). This represents 101% of the company’s total 45,283,737 outstanding shares.
13F concentration
Top 25 institutional shareholders
Largest 13F positions for this security by reported shares and value.
Top holder share
95%
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 15% | 6,995,858 | 0% | 1.8% | $168,110,468 |
| TRV GP V, LLC | 14% | 6,215,591 | 0% | 37% | $149,360,652 |
| Driehaus Capital Management LLC | 9.7% | 4,395,572 | -8.6% | 0.78% | $105,625,595 |
| TRV GP VI, LLC | 9.3% | 4,211,659 | 0% | 75% | $101,206,166 |
| SAMSARA BIOCAPITAL, LLC | 7% | 3,149,128 | 0% | 7.4% | $75,673,546 |
| GOLDMAN SACHS GROUP INC | 6.4% | 2,906,427 | +7% | 0.01% | $69,841,441 |
| Siren, L.L.C. | 4.4% | 2,000,000 | 0% | 1.3% | $48,060,000 |
| BlackRock, Inc. | 4% | 1,822,174 | +1.2% | 0% | $43,786,841 |
| BVF INC/IL | 3% | 1,353,249 | -21% | 1% | $32,518,573 |
| Avoro Capital Advisors LLC | 3% | 1,337,500 | 0% | 0.32% | $32,140,125 |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.6% | 1,196,962 | 0% | 0% | $28,762,997 |
| ADAR1 Capital Management, LLC | 2.4% | 1,089,818 | -5.9% | 1.6% | $26,188,327 |
| PRIMECAP MANAGEMENT CO/CA/ | 2.3% | 1,048,834 | +92% | 0.02% | $25,203,482 |
| JANUS HENDERSON GROUP PLC | 2% | 890,754 | 0.01% | $21,333,558 | |
| First Light Asset Management, LLC | 1.6% | 732,860 | +18% | 1.6% | $17,610,626 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.4% | 645,146 | +13% | 0% | $15,506,147 |
| STATE STREET CORP | 1.4% | 631,447 | +17% | 0% | $15,173,671 |
| Casdin Capital, LLC | 1.2% | 553,268 | 0% | 1% | $13,295,030 |
| Venrock Adviser, LLC | 1.1% | 506,056 | -17% | 0.45% | $12,160,526 |
| Catalio Capital Management, LP | 0.65% | 294,360 | 0% | 1.5% | $7,073,471 |
| Soleus Capital Management, L.P. | 0.61% | 275,000 | -28% | 0.27% | $6,608,250 |
| Balyasny Asset Management L.P. | 0.52% | 236,679 | +6528% | 0.01% | $5,687,396 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.49% | 223,995 | +0.58% | 0.01% | $5,382,600 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 0.43% | 195,043 | 0% | 0% | $4,686,883 |
| Kalehua Capital Management LLC | 0.43% | 194,544 | 0% | 3.3% | $4,674,892 |
Quarter history
Institutional holders across reporting periods
Holder count, reported shares/value, and median price by quarter.
Periods
6
Latest
Q1 2026
Rows shown
1-6 of 6
| Period | 13F Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q1 | 45,721,668 | $1,098,633,508 | -$3,059,970 | $24.03 | 124 |
| 2025 Q4 | 45,591,200 | $1,270,965,588 | +$27,717,426 | $27.88 | 123 |
| 2025 Q3 | 44,549,033 | $837,968,810 | +$6,406,374 | $18.81 | 82 |
| 2025 Q2 | 44,430,464 | $469,630,218 | -$8,199,247 | $10.57 | 89 |
| 2025 Q1 | 45,290,316 | $262,246,506 | -$67,734,233 | $5.79 | 69 |
| 2024 Q4 | 44,129,388 | $1,010,571,873 | +$770,183,886 | $22.90 | 71 |