Latest Period
Q2 2026
Security Snapshot
Septerna, Inc. - Common Stock (SEPN) Institutional Ownership
CUSIP: 81734D104
13F Institutional Holders and Ownership History from Q4 2024 to Q2 2026
Institutions Reporting
152
Shares (Excl. Options)
47,219,112
Price
$33.49
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- Security type / class
- Equity / Common Stock
- Symbol
- SEPN on Nasdaq
- All holders as of 30 Jun 2026
- Q2 2026
- Total 13F shares
- 47,219,112
- Total 13F value
- $1,581,131,125
- Portfolio coverage rank
- 0%
- Share change
- +1,069,908
- Value change
- +$55,802,753
- Number of holders
- 152
- Shares outstanding
- 45,097,233
- SEC-reported price per share
- $33.10
- Insider filing price
- $33.10
Latest holder snapshot
5 signals
Issuer context
Names, identifiers, and filing context for this profile.
3 identity fields
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors
Key facts
- SEPN - Septerna, Inc. - Common Stock is tracked under CUSIP 81734D104.
- 152 institutions reported positions in Q2 2026.
- 4 significant owners is listed from Schedule 13D/13G reporting.
Change
- Holder count moved from 124 to 152 between Q1 2026 and Q2 2026.
- SEC-reported value moved from $1,098,633,979 to $1,581,131,125.
Research use
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Evidence
Source: SEC Form 13F
Open SEC evidence
Latest holder context comes from 152 institutions filings for Q2 2026.
Security key
81734D104
Latest holder period
Q2 2026
13F holders
152
13D/G owners
4
CIK / CUSIP context first
Open Q2 2026 holders
SEPN full holder history
Septerna, Inc. SEC filings
Septerna, Inc. company facts
Septerna, Inc. insider transactions
Broader feeds
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 81734D104:
13D/G owners
Significant owners
Large-stake holder rows connected to Schedule 13D/G evidence.
Rows
4
Security
SEPN
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Third Rock Ventures V, L.P. | 14% | 0% | $43,509,137 | 6,215,591 | 0% | Third Rock Ventures V, L.P. | 31 Mar 2025 | |
| RA CAPITAL MANAGEMENT, L.P. | 12% | $185,043,101 | 5,525,324 | RA Capital Management, L.P. | 12 Aug 2026 | |||
| DRIEHAUS CAPITAL MANAGEMENT LLC | 9.8% | -6.3% | $148,463,112 | -$7,597,307 | 4,433,058 | -4.9% | DRIEHAUS CAPITAL MANAGEMENT LLC | 30 Jun 2026 |
| BIOTECHNOLOGY VALUE FUND L P | 3.8% | -61% | $42,813,056 | -$66,562,509 | 1,720,782 | -61% | BVF PARTNERS L P/IL | 31 Dec 2025 |
As of 30 Jun 2026, 152 institutional investors reported holding 47,219,112 shares of Septerna, Inc. - Common Stock (SEPN). This represents 105% of the company’s total 45,097,233 outstanding shares.
13F concentration
Top 25 institutional shareholders
Largest 13F positions for this security by reported shares and value.
Top holder share
97%
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 16% | 6,995,858 | 0% | 2% | $234,291,284 |
| TRV GP V, LLC | 14% | 6,215,591 | 0% | 42% | $208,160,143 |
| Driehaus Capital Management LLC | 9.8% | 4,433,058 | +0.85% | 0.86% | $148,463,112 |
| TRV GP VI, LLC | 9.3% | 4,211,659 | 0% | 61% | $141,048,460 |
| SAMSARA BIOCAPITAL, LLC | 7% | 3,149,128 | 0% | 8.7% | $105,464,297 |
| GOLDMAN SACHS GROUP INC | 6.8% | 3,062,766 | +5.4% | 0.01% | $102,572,033 |
| BlackRock, Inc. | 4.3% | 1,932,088 | +6% | 0% | $64,705,629 |
| Siren, L.L.C. | 4.2% | 1,900,000 | -5% | 1.3% | $63,631,000 |
| Avoro Capital Advisors LLC | 3% | 1,337,500 | 0% | 0.4% | $44,792,875 |
| Jupiter Topco LLC | 2.9% | 1,307,500 | 0% | 0.02% | $43,722,800 |
| VANGUARD CAPITAL MANAGEMENT LLC | 2.7% | 1,221,673 | +2.1% | 0% | $40,913,829 |
| PRIMECAP MANAGEMENT CO/CA/ | 2.6% | 1,167,382 | +11% | 0.02% | $39,095,624 |
| First Light Asset Management, LLC | 2.1% | 963,260 | +31% | 2% | $32,259,577 |
| ADAR1 Capital Management, LLC | 2.1% | 940,747 | -14% | 1.5% | $31,505,617 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.5% | 679,163 | +5.3% | 0% | $22,750,071 |
| STATE STREET CORP | 1.4% | 652,630 | +3.4% | 0% | $21,856,579 |
| LOOMIS SAYLES & CO L P | 1.4% | 624,752 | 0.03% | $20,922,944 | |
| Casdin Capital, LLC | 1.2% | 553,268 | 0% | 0.93% | $18,528,945 |
| Catalio Capital Management, LP | 1.2% | 536,152 | +82% | 3.4% | $17,955,730 |
| ALGERT GLOBAL LLC | 0.88% | 397,487 | +1790% | 0.16% | $13,311,840 |
| Balyasny Asset Management L.P. | 0.78% | 350,442 | +48% | 0.02% | $11,736,303 |
| Longaeva Partners L.P. | 0.66% | 298,171 | +300% | 0.29% | $9,985,747 |
| Soleus Capital Management, L.P. | 0.61% | 275,000 | 0% | 0.32% | $9,209,750 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 0.51% | 230,184 | +18% | 0% | $7,708,862 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.49% | 222,702 | -0.58% | 0.01% | $7,458,290 |
Quarter history
Institutional holders across reporting periods
Holder count, reported shares/value, and median price by quarter.
Periods
7
Latest
Q2 2026
Rows shown
1-7 of 7
| Period | 13F Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q2 | 47,219,112 | $1,581,131,125 | +$55,802,753 | $33.49 | 152 |
| 2026 Q1 | 45,721,668 | $1,098,633,979 | -$3,060,281 | $24.03 | 124 |
| 2025 Q4 | 45,591,200 | $1,270,965,588 | +$27,717,426 | $27.88 | 123 |
| 2025 Q3 | 44,549,033 | $837,968,810 | +$6,406,374 | $18.81 | 82 |
| 2025 Q2 | 44,430,464 | $469,630,218 | -$8,199,247 | $10.57 | 89 |
| 2025 Q1 | 45,290,316 | $262,246,506 | -$67,734,233 | $5.79 | 69 |
| 2024 Q4 | 44,129,388 | $1,010,571,873 | +$770,183,886 | $22.90 | 71 |