Latest Period
Q4 2025
Security Snapshot
Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) Institutional Ownership
CUSIP: 81734D104
13F Institutional Holders and Ownership History from Q4 2024 to Q1 2026
Institutions Reporting
123
Shares (Excl. Options)
45,591,200
Price
$27.88
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- Type / Class
- Equity / Common Stock, $0.001 par value per share
- Symbol
- SEPN on Nasdaq
- Shares outstanding
- 45,283,737
- Price per share
- $23.34
- All holders as of 31 Dec 2025
- Q4 2025
- Total 13F shares
- 45,591,200
- Total reported value
- $1,270,965,588
- % of total 13F portfolios
- 0%
- Share change
- +812,198
- Value change
- +$27,717,426
- Number of holders
- 123
- Price from insider filings
- $23.34
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors
Quick Takeaways
- SEPN - Septerna, Inc. - Common Stock, $0.001 par value per share is tracked under CUSIP 81734D104.
- 123 institutions reported positions in Q4 2025.
- 3 significant owners is listed from Schedule 13D/13G reporting.
What Changed
- Holder count moved from 123 to 27 between Q4 2025 and Q1 2026.
- Reported value moved from $1,270,965,588 to $258,302,152.
Why This Matters
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Source Evidence
Source: SEC Form 13F
Open SEC Evidence
Latest holder context comes from 123 institutions filings for Q4 2025.
Investment Quick Answers
What is CUSIP 81734D104?
CUSIP 81734D104 identifies SEPN - Septerna, Inc. - Common Stock, $0.001 par value per share in SEC 13F datasets.
Where can I see the latest institutional holders?
Review the Q4 2025 holders report and the ownership history table below.
Next ownership checks
Use the next link that matches the question you still need to answer about this security.
- Latest 13F filings when you want to inspect fresh institutional portfolio moves.
- Latest Schedule 13D/13G reports when you need large-owner changes outside the 13F cycle.
- All institutional ownership pages to compare this security with other holder-history pages.
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 81734D104:
Significant Owners of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) based on Schedule 13D/G filings
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Third Rock Ventures V, L.P. | 14% | 0% | $43,509,137 | 6,215,591 | 0% | Third Rock Ventures V, L.P. | 31 Mar 2025 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 10% | +49% | $31,361,201 | +$10,346,049 | 4,659,911 | +49% | DRIEHAUS CAPITAL MANAGEMENT LLC | 31 May 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 3.8% | -61% | $42,813,056 | -$66,562,509 | 1,720,782 | -61% | BVF PARTNERS L P/IL | 31 Dec 2025 |
As of 31 Dec 2025, 123 institutional investors reported holding 45,591,200 shares of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN). This represents 101% of the company’s total 45,283,737 outstanding shares.
Top 25 Institutional Shareholders
The largest institutional shareholders of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) together control 95% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 15% | 6,995,858 | 0% | 2% | $195,044,521 |
| TRV GP V, LLC | 14% | 6,215,591 | 0% | 40% | $173,290,677 |
| Driehaus Capital Management LLC | 11% | 4,809,470 | -2.2% | 0.91% | $134,088,024 |
| TRV GP VI, LLC | 9.3% | 4,211,659 | 0% | 79% | $117,421,053 |
| SAMSARA BIOCAPITAL, LLC | 7% | 3,149,128 | 0% | 9.1% | $87,797,689 |
| GOLDMAN SACHS GROUP INC | 6% | 2,715,129 | +87% | 0.01% | $75,697,796 |
| Siren, L.L.C. | 4.4% | 2,000,000 | -9.2% | 1.7% | $55,760,000 |
| BlackRock, Inc. | 4% | 1,801,328 | +23% | 0% | $50,221,023 |
| BVF INC/IL | 3.8% | 1,720,782 | -57% | 1.6% | $47,975,402 |
| VANGUARD GROUP INC | 3.3% | 1,508,195 | -0.7% | 0% | $42,048,476 |
| Avoro Capital Advisors LLC | 3% | 1,337,500 | 0% | 0.37% | $37,289,500 |
| ADAR1 Capital Management, LLC | 2.6% | 1,157,611 | -1.6% | 2.4% | $32,274,195 |
| First Light Asset Management, LLC | 1.4% | 620,811 | 1.3% | $17,308,211 | |
| VR ADVISER, LLC | 1.3% | 610,808 | 0% | 0.84% | $17,029,327 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.3% | 572,734 | +5% | 0% | $15,971,458 |
| Casdin Capital, LLC | 1.2% | 553,268 | 0% | 0.96% | $15,425,112 |
| PRIMECAP MANAGEMENT CO/CA/ | 1.2% | 546,100 | 0.01% | $15,225,268 | |
| STATE STREET CORP | 1.2% | 540,028 | +29% | 0% | $15,055,981 |
| PERCEPTIVE ADVISORS LLC | 0.96% | 433,160 | -20% | 0.22% | $12,076,501 |
| Woodline Partners LP | 0.85% | 385,310 | +36% | 0.04% | $10,742,443 |
| Soleus Capital Management, L.P. | 0.85% | 383,368 | +1999% | 0.45% | $10,688,300 |
| Catalio Capital Management, LP | 0.65% | 294,360 | 0% | 1.5% | $8,206,757 |
| MARSHALL WACE, LLP | 0.5% | 226,901 | 0.01% | $6,326,001 | |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.49% | 222,702 | 0% | 0.01% | $6,208,932 |
| Kalehua Capital Management LLC | 0.43% | 194,544 | 0% | 5.5% | $5,423,887 |
Institutional Holders of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) across Reporting Periods
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q1 | 10,749,166 | $258,302,152 | +$2,398,763 | $24.03 | 27 |
| 2025 Q4 | 45,591,200 | $1,270,965,588 | +$27,717,426 | $27.88 | 123 |
| 2025 Q3 | 44,549,033 | $837,968,810 | +$6,406,374 | $18.81 | 82 |
| 2025 Q2 | 44,430,464 | $469,630,218 | -$8,199,247 | $10.57 | 89 |
| 2025 Q1 | 45,290,316 | $262,246,506 | -$67,734,233 | $5.79 | 69 |
| 2024 Q4 | 44,129,388 | $1,010,571,873 | +$770,183,886 | $22.90 | 71 |