Quick Takeaways
- SEPN - Septerna, Inc. has 19 insiders with reported activity on this page.
- Net insider value flow over the last year: -$2,158,922.
- Recent transaction rows are available for direct filing-level review.
- Info
- Insider Trading
- Financials
- Holders
Insider Transactions Reported by 19 Insiders of Septerna, Inc.
- Symbol
- SEPN on Nasdaq
- Location
- South San Francisco, CA
What Changed
- Buy value: ; sell value: $2,158,921.
- Net share flow: -77,954.
Why This Matters
- This page gives a plain-language issuer insider context before you inspect transaction-level evidence.
- Use the filing links below to verify timestamps, codes, and ownership impacts directly from SEC forms.
Official SEC Source
Insider trading overview
Last 12 monthsNet insider flow leans to selling over the last 12 months. Net value: -$2,158,922.
Buys
$0
Shares: 0
Insiders: 0
Sells
$2,158,922
Shares: 77,954
Insiders: 3
Net
-$2,158,922
Shares: -77,954
Insiders: -3
| Window (months) | Buy shares | Sell shares | Buy $ | Sell $ | Net $ |
|---|---|---|---|---|---|
| 0-3 | 0 | 74,453 | $0 | $2,095,699 | -$2,095,699 |
| 3-6 | 0 | 3,501 | $0 | $63,223 | -$63,223 |
| 6-9 | 0 | 0 | $0 | $0 | $0 |
| 9-12 | 0 | 0 | $0 | $0 | $0 |
Septerna, Inc. executives and other stock owners filed with the SEC include:
| Name | Relationship | Holdings Value | Past Year Net Change | Change % | Valuation | Report Date |
|---|---|---|---|---|---|---|
| Third Rock Ventures VI, L.P. | 10%+ Owner | $62,553,072 | Mixed | 24 Feb 2025 | ||
| Third Rock Ventures V, L.P. | 10%+ Owner | $54,803,075 | Mixed | 28 Oct 2024 | ||
| RA CAPITAL MANAGEMENT, L.P. | Director, 10%+ Owner | $8,610,867 | Mixed | 17 Jun 2025 | ||
| Elizabeth Bhatt | President and COO | $5,153,642 | -$115,860 | -2.2% | Filing P/S | 18 Feb 2026 |
| Jeffrey Finer | Chief Executive Officer, Director | $2,282,263 | Mixed | 06 Feb 2026 | ||
| Daniel D. Long | SVP, Drug Discovery | $1,677,842 | -$63,223 | -3.6% | Filing P/S | 06 Feb 2026 |
| Uwe Klein | SVP, Biological Sciences | $1,477,880 | Mixed | 06 Feb 2026 | ||
| Alan Ezekowitz | Director | $813,451 | Filing P/S | 17 Jun 2025 | ||
| Ran Xiao | Interim CFO | $339,704 | Mixed | 24 Oct 2024 | ||
| Gil M. Labrucherie | Chief Financial Officer | $234,000 | Filing P/S | 06 Feb 2026 | ||
| Samira Shaikhly | Chief People Officer | $22,313 | -$1,979,838 | -99% | Filing P/S | 02 Mar 2026 |
| Jake Simson | Director | Mixed | 17 Jun 2025 | |||
| Shalini Sharp | Director | Mixed | 17 Jun 2025 | |||
| Abraham Bassan | Director | Mixed | 17 Jun 2025 | |||
| Jeffrey K. Tong | Director | Mixed | 17 Jun 2025 | |||
| Keith Michael Gottesdiener | Director | Mixed | 25 Sep 2025 | |||
| Jae B. Kim | Chief Medical Officer | Mixed | 06 Feb 2026 | |||
| Mark A. Wilson | Chief Legal Officer | Mixed | 06 Feb 2026 | |||
| Bernard Coulie | Director | Mixed | 17 Jun 2025 |
Top shareholders of Septerna, Inc. (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. |
13F
3/4/5
|
Company · Director, 10%+ Owner |
15%
|
6,995,858
|
$195,044,521 | — | 31 Dec 2025 | |
| TRV GP V, LLC |
13F
|
Company |
14%
|
6,215,591
|
$173,290,677 | — | 31 Dec 2025 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
13F
13D/G
|
Company |
10%
from 13D/G
|
4,809,470
|
$134,088,024 | — | 31 Dec 2025 | |
| TRV GP VI, LLC |
13F
|
Company |
9.3%
|
4,211,659
|
$117,421,053 | — | 31 Dec 2025 | |
| Samsara BioCapital, LLC |
13F
|
Company |
7%
|
3,149,128
|
$87,797,689 | — | 31 Dec 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
6%
|
2,715,129
|
$75,697,796 | — | 31 Dec 2025 | |
| Third Rock Ventures VI, L.P. |
3/4/5
|
10%+ Owner |
—
class O/S missing
|
10,427,250
|
$62,553,072 | — | 24 Feb 2025 | |
| Siren, L.L.C. |
13F
|
Individual |
4.4%
|
2,000,000
|
$55,760,000 | — | 31 Dec 2025 | |
| Third Rock Ventures V, L.P. |
3/4/5
13D/G
|
10%+ Owner |
14%
from 13D/G
|
9,368,047
|
$54,803,075 | — | 28 Oct 2024 | |
| BlackRock, Inc. |
13F
|
Company |
4%
|
1,801,328
|
$50,221,023 | — | 31 Dec 2025 | |
| BVF INC/IL |
13F
|
Company |
3.8%
|
1,720,782
|
$47,975,402 | — | 31 Dec 2025 | |
| BIOTECHNOLOGY VALUE FUND L P |
13D/G
|
BVF PARTNERS L P/IL |
3.8%
|
1,720,782
|
$42,813,056 | -$66,562,509 | 31 Dec 2025 | |
| VANGUARD GROUP INC |
13F
|
Company |
3.3%
|
1,508,195
|
$42,048,476 | — | 31 Dec 2025 | |
| Avoro Capital Advisors LLC |
13F
|
Company |
3%
|
1,337,500
|
$37,289,500 | — | 31 Dec 2025 | |
| ADAR1 Capital Management, LLC |
13F
|
Company |
2.6%
|
1,157,611
|
$32,274,195 | — | 31 Dec 2025 | |
| First Light Asset Management, LLC |
13F
|
Company |
1.4%
|
620,811
|
$17,308,211 | — | 31 Dec 2025 | |
| VR Adviser, LLC |
13F
|
Company |
1.3%
|
610,808
|
$17,029,327 | — | 31 Dec 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
1.3%
|
572,734
|
$15,971,458 | — | 31 Dec 2025 | |
| Casdin Capital, LLC |
13F
|
Company |
1.2%
|
553,268
|
$15,425,112 | — | 31 Dec 2025 | |
| PRIMECAP MANAGEMENT CO/CA/ |
13F
|
Company |
1.2%
|
546,100
|
$15,225,268 | — | 31 Dec 2025 | |
| STATE STREET CORP |
13F
|
Company |
1.2%
|
540,028
|
$15,055,981 | — | 31 Dec 2025 | |
| PERCEPTIVE ADVISORS LLC |
13F
|
Company |
0.96%
|
433,160
|
$12,076,501 | — | 31 Dec 2025 | |
| Woodline Partners LP |
13F
|
Company |
0.85%
|
385,310
|
$10,742,443 | — | 31 Dec 2025 | |
| Soleus Capital Management, L.P. |
13F
|
Company |
0.85%
|
383,368
|
$10,688,300 | — | 31 Dec 2025 | |
| Catalio Capital Management, LP |
13F
|
Company |
0.65%
|
294,360
|
$8,206,757 | — | 31 Dec 2025 | |
| MARSHALL WACE, LLP |
13F
|
Company |
0.5%
|
226,901
|
$6,326,001 | — | 31 Dec 2025 | |
| Universal- Beteiligungs- und Servicegesellschaft mbH |
13F
|
Individual |
0.49%
|
222,702
|
$6,208,932 | — | 31 Dec 2025 | |
| Kalehua Capital Management LLC |
13F
|
Company |
0.43%
|
194,544
|
$5,423,887 | — | 31 Dec 2025 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.41%
|
187,241
|
$5,220,279 | — | 31 Dec 2025 | |
| Elizabeth Bhatt |
3/4/5
|
President and COO |
—
mixed-class rows
|
263,120
mixed-class rows
|
$5,153,642 | -$115,860 | 18 Feb 2026 | |
| Invesco Ltd. |
13F
|
Company |
0.36%
|
162,014
|
$4,516,950 | — | 31 Dec 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.34%
|
154,196
|
$4,298,985 | — | 31 Dec 2025 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
0.24%
|
107,463
|
$2,996,068 | — | 31 Dec 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.23%
|
103,985
|
$2,899,101 | — | 31 Dec 2025 | |
| TWO SIGMA INVESTMENTS, LP |
13F
|
Company |
0.2%
|
92,809
|
$2,587,515 | — | 31 Dec 2025 | |
| Jeffrey Finer |
3/4/5
|
Chief Executive Officer, Director |
—
mixed-class rows
|
1,226,907
mixed-class rows
|
$2,282,263 | — | 06 Feb 2026 | |
| FEDERATED HERMES, INC. |
13F
|
Company |
0.17%
|
78,905
|
$2,199,872 | — | 31 Dec 2025 | |
| HighVista Strategies LLC |
13F
|
Company |
0.17%
|
78,682
|
$2,193,654 | — | 31 Dec 2025 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
0.17%
|
75,945
|
$2,117,347 | — | 31 Dec 2025 | |
| UBS Group AG |
13F
|
Company |
0.15%
|
68,817
|
$1,918,618 | — | 31 Dec 2025 | |
| JPMORGAN CHASE & CO |
13F
|
Company |
0.15%
|
68,338
|
$1,905,263 | — | 31 Dec 2025 | |
| Rangeley Capital, LLC |
13F
|
Company |
0.15%
|
65,800
|
$1,834,504 | — | 31 Dec 2025 | |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
13F
|
Company |
0.14%
|
61,370
|
$1,710,996 | — | 31 Dec 2025 | |
| Daniel D. Long |
3/4/5
|
SVP, Drug Discovery |
—
mixed-class rows
|
172,911
mixed-class rows
|
$1,677,842 | -$63,223 | 06 Feb 2026 | |
| Bank of New York Mellon Corp |
13F
|
Company |
0.12%
|
55,332
|
$1,542,657 | — | 31 Dec 2025 | |
| Uwe Klein |
3/4/5
|
SVP, Biological Sciences |
—
mixed-class rows
|
207,533
mixed-class rows
|
$1,477,880 | — | 06 Feb 2026 | |
| AMERICAN CENTURY COMPANIES INC |
13F
|
Company |
0.11%
|
50,689
|
$1,413,209 | — | 31 Dec 2025 | |
| Longaeva Partners L.P. |
13F
|
Company |
0.11%
|
49,902
|
$1,391,268 | — | 31 Dec 2025 | |
| Numerai GP LLC |
13F
|
Company |
0.1%
|
45,866
|
$1,278,744 | — | 31 Dec 2025 | |
| JANE STREET GROUP, LLC |
13F
|
Company |
0.1%
|
44,070
|
$1,228,671 | — | 31 Dec 2025 |
Recent Insider Transactions by Companies or Individuals for Septerna, Inc.
Showing up to 300 most recent insider transactions from the last 12 months.
| Insider | Symbol | Class | Transaction | % | Value $ | * Price $ | Shares | Shares Owned | Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|---|
| Samira Shaikhly | SEPN | Common Stock | Sale | -98.9% | $1,979,838 | $28.10 | -70,453 | 793 | 02 Mar 2026 | Direct |
| Samira Shaikhly | SEPN | Common Stock | Options Exercise | 8884.4% | 70,453 | 71,246 | 02 Mar 2026 | Direct | ||
| Samira Shaikhly | SEPN | Stock Option (Right to Buy) | Options Exercise | -95.3% | -70,453 | 3,460 | 02 Mar 2026 | Direct | ||
| Elizabeth Bhatt | SEPN | Common Stock | Sale | -2.24% | $115,860 | $28.97 | -4,000 | 174,209 | 18 Feb 2026 | Direct |
| Elizabeth Bhatt | SEPN | Common Stock | Options Exercise | 2.3% | 4,000 | 178,209 | 18 Feb 2026 | Direct | ||
| Elizabeth Bhatt | SEPN | Stock Option (Right to Buy) | Options Exercise | -4.31% | -4,000 | 88,911 | 18 Feb 2026 | Direct | ||
| Daniel D. Long | SEPN | Stock Option (Right to Buy) | Award | 80,000 | 80,000 | 06 Feb 2026 | Direct | |||
| Uwe Klein | SEPN | Stock Option (Right to Buy) | Award | 80,000 | 80,000 | 06 Feb 2026 | Direct | |||
| Samira Shaikhly | SEPN | Stock Option (Right to Buy) | Award | 80,000 | 80,000 | 06 Feb 2026 | Direct | |||
| Gil M. Labrucherie | SEPN | Stock Option (Right to Buy) | Award | 125,000 | 125,000 | 06 Feb 2026 | Direct | |||
| Jae B. Kim | SEPN | Stock Option (Right to Buy) | Award | 125,000 | 125,000 | 06 Feb 2026 | Direct | |||
| Elizabeth Bhatt | SEPN | Stock Option (Right to Buy) | Award | 155,000 | 155,000 | 06 Feb 2026 | Direct | |||
| Jeffrey Finer | SEPN | Stock Option (Right to Buy) | Award | 400,000 | 400,000 | 06 Feb 2026 | Direct | |||
| Mark A. Wilson | SEPN | Stock Option (Right to Buy) | Award | 165,000 | 165,000 | 06 Feb 2026 | Direct | |||
| Daniel D. Long | SEPN | Common Stock | Sale | -3.63% | $63,223 | $18.06 | -3,501 | 92,911 | 10 Nov 2025 | Direct |
| Keith Michael Gottesdiener | SEPN | Stock Option (Right to Buy) | Award | 33,246 | 33,246 | 25 Sep 2025 | Direct | |||
| Uwe Klein | SEPN | Common Stock | Options Exercise | 23,008 | 23,008 | 18 Aug 2025 | Direct | |||
| Uwe Klein | SEPN | Stock Option (Right to Buy) | Options Exercise | -71.9% | -23,008 | 9,001 | 18 Aug 2025 | Direct | ||
| Samira Shaikhly | SEPN | Stock Option (Right to Buy) | Award | 30,000 | 30,000 | 07 Aug 2025 | Direct | |||
| Elizabeth Bhatt | SEPN | Stock Option (Right to Buy) | Award | 95,000 | 95,000 | 07 Aug 2025 | Direct | |||
| Jae B. Kim | SEPN | Stock Option (Right to Buy) | Award | 55,000 | 55,000 | 07 Aug 2025 | Direct | |||
| Gil M. Labrucherie | SEPN | Stock Option (Right to Buy) | Award | 37,500 | 37,500 | 07 Aug 2025 | Direct | |||
| Jeffrey Finer | SEPN | Stock Option (Right to Buy) | Award | 210,000 | 210,000 | 07 Aug 2025 | Direct | |||
| Daniel D. Long | SEPN | Stock Option (Right to Buy) | Award | 30,000 | 30,000 | 07 Aug 2025 | Direct | |||
| Uwe Klein | SEPN | Stock Option (Right to Buy) | Award | 30,000 | 30,000 | 07 Aug 2025 | Direct | |||
| Ra Capital Management, L.P. | SEPN | Stock Option (Right to Buy) | Award | 16,623 | 16,623 | 17 Jun 2025 | See Footnotes | |||
| Shalini Sharp | SEPN | Stock Option (Right to Buy) | Award | 16,623 | 16,623 | 17 Jun 2025 | Direct | |||
| Jeffrey K. Tong | SEPN | Stock Option (Right to Buy) | Award | 16,623 | 16,623 | 17 Jun 2025 | Direct | |||
| Bernard Coulie | SEPN | Stock Option (Right to Buy) | Award | 16,623 | 16,623 | 17 Jun 2025 | Direct | |||
| Jake Simson | SEPN | Stock Option (Right to Buy) | Award | 16,623 | 16,623 | 17 Jun 2025 | Direct | |||
| Abraham Bassan | SEPN | Stock Option (Right to Buy) | Award | 16,623 | 16,623 | 17 Jun 2025 | Direct | |||
| Alan Ezekowitz | SEPN | Stock Option (Right to Buy) | Award | 16,623 | 16,623 | 17 Jun 2025 | Direct |
* An asterisk sign (*) next to the price indicates that the price is likely invalid.