Security key
81734D104
Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN)
CUSIP: 81734D104
Q4 2025 13F Holders as of 31 Dec 2025
- Type / Class
- Equity / Common Stock, $0.001 par value per share
- Shares outstanding
- 45,283,737
- Total 13F shares
- 45,591,200
- Share change
- +812,198
- Total reported value
- $1,270,965,588
- Put/Call ratio
- 221%
- Price per share
- $27.88
- Number of holders
- 123
- Value change
- +$27,717,426
- Number of buys
- 72
- Number of sells
- 32
Report period
Q4 2025
Institutions
123
Top holders
10
SEPN full security history
Newer quarter: Q1 2026
Previous quarter: Q3 2025
Septerna, Inc. SEC filings
Septerna, Inc. company facts
Broader feeds
Reporting periods
Holder history for CUSIP 81734D104
Recent filing periods:
Top shareholders of SEPN - Septerna, Inc. - Common Stock, $0.001 par value per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. |
13F
3/4/5
|
Company · Director, 10%+ Owner |
15%
|
6,995,858
|
$131,592,089 | — | 30 Sep 2025 | |
| TRV GP V, LLC |
13F
|
Company |
14%
|
6,215,591
|
$116,915,267 | — | 30 Sep 2025 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
13F
13D/G
|
Company |
10%
from 13D/G
|
4,919,896
|
$92,543,244 | — | 30 Sep 2025 | |
| TRV GP VI, LLC |
13F
|
Company |
9.3%
|
4,211,659
|
$79,221,306 | — | 30 Sep 2025 | |
| BVF INC/IL |
13F
|
Company |
8.9%
|
4,015,790
|
$75,537,010 | — | 30 Sep 2025 | |
| Third Rock Ventures VI, L.P. |
3/4/5
|
10%+ Owner |
—
class O/S missing
|
10,427,250
|
$62,553,072 | — | 24 Feb 2025 | |
| Samsara BioCapital, LLC |
13F
|
Company |
7%
|
3,149,128
|
$59,235,098 | — | 30 Sep 2025 | |
| Third Rock Ventures V, L.P. |
3/4/5
13D/G
|
10%+ Owner |
14%
from 13D/G
|
9,368,047
|
$54,803,075 | — | 28 Oct 2024 | |
| BIOTECHNOLOGY VALUE FUND L P |
13D/G
|
BVF PARTNERS L P/IL |
3.8%
|
1,720,782
|
$42,813,056 | -$66,562,509 | 31 Dec 2025 | |
| Siren, L.L.C. |
13F
|
Individual |
4.9%
|
2,202,514
|
$41,429,288 | — | 30 Sep 2025 | |
| VANGUARD GROUP INC |
13F
|
Company |
3.4%
|
1,518,757
|
$28,567,819 | — | 30 Sep 2025 | |
| BlackRock, Inc. |
13F
|
Company |
3.2%
|
1,459,795
|
$27,458,744 | — | 30 Sep 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
3.2%
|
1,454,720
|
$27,363,283 | — | 30 Sep 2025 | |
| Avoro Capital Advisors LLC |
13F
|
Company |
3%
|
1,337,500
|
$25,158,375 | — | 30 Sep 2025 | |
| ADAR1 Capital Management, LLC |
13F
|
Company |
2.6%
|
1,176,491
|
$22,129,796 | — | 30 Sep 2025 | |
| VR Adviser, LLC |
13F
|
Company |
1.3%
|
610,808
|
$11,489,298 | — | 30 Sep 2025 | |
| Casdin Capital, LLC |
13F
|
Company |
1.2%
|
553,268
|
$10,406,971 | — | 30 Sep 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
1.2%
|
545,701
|
$10,266,005 | — | 30 Sep 2025 | |
| PERCEPTIVE ADVISORS LLC |
13F
|
Company |
1.2%
|
541,450
|
$10,184,675 | — | 30 Sep 2025 | |
| STATE STREET CORP |
13F
|
Company |
0.93%
|
418,960
|
$7,880,638 | — | 30 Sep 2025 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
0.85%
|
384,200
|
$7,226,802 | — | 30 Sep 2025 | |
| Catalio Capital Management, LP |
13F
|
Company |
0.65%
|
294,360
|
$5,536,912 | — | 30 Sep 2025 | |
| Checkpoint Capital L.P. |
13F
|
Company |
0.63%
|
283,158
|
$5,326,202 | — | 30 Sep 2025 | |
| Woodline Partners LP |
13F
|
Company |
0.62%
|
282,585
|
$5,315,424 | — | 30 Sep 2025 | |
| Universal- Beteiligungs- und Servicegesellschaft mbH |
13F
|
Individual |
0.49%
|
222,702
|
$4,189,025 | — | 30 Sep 2025 | |
| Sio Capital Management, LLC |
13F
|
Company |
0.42%
|
189,199
|
$3,558,833 | — | 30 Sep 2025 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.41%
|
186,904
|
$3,515,664 | — | 30 Sep 2025 | |
| Invesco Ltd. |
13F
|
Company |
0.39%
|
177,070
|
$3,330,687 | — | 30 Sep 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.37%
|
167,345
|
$3,147,759 | — | 30 Sep 2025 | |
| TWO SIGMA INVESTMENTS, LP |
13F
|
Company |
0.2%
|
92,334
|
$1,736,803 | — | 30 Sep 2025 | |
| Rangeley Capital, LLC |
13F
|
Company |
0.19%
|
88,000
|
$1,655,280 | — | 30 Sep 2025 | |
| Logos Global Management LP |
13F
|
Company |
0.18%
|
83,548
|
$1,571,538 | — | 30 Sep 2025 | |
| Walleye Capital LLC |
13F
|
Company |
0.18%
|
80,341
|
$1,511,214 | — | 30 Sep 2025 | |
| UBS Group AG |
13F
|
Company |
0.13%
|
59,046
|
$1,110,655 | — | 30 Sep 2025 | |
| Longaeva Partners L.P. |
13F
|
Company |
0.13%
|
57,064
|
$1,073,374 | — | 30 Sep 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.12%
|
54,458
|
$1,024,354 | — | 30 Sep 2025 | |
| Bank of New York Mellon Corp |
13F
|
Company |
0.11%
|
51,631
|
$971,179 | — | 30 Sep 2025 | |
| BANK OF AMERICA CORP /DE/ |
13F
|
Company |
0.11%
|
51,495
|
$968,622 | — | 30 Sep 2025 | |
| Alan Ezekowitz |
3/4/5
|
Director |
—
mixed-class rows
|
134,043
mixed-class rows
|
$813,451 | — | 17 Jun 2025 | |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
13F
|
Company |
0.08%
|
35,778
|
$672,984 | — | 30 Sep 2025 | |
| Alyeska Investment Group, L.P. |
13F
|
Company |
0.08%
|
35,000
|
$658,350 | — | 30 Sep 2025 | |
| BARCLAYS PLC |
13F
|
Company |
0.07%
|
30,102
|
$566,218 | — | 30 Sep 2025 | |
| RHUMBLINE ADVISERS |
13F
|
Company |
0.06%
|
27,604
|
$519,224 | — | 30 Sep 2025 | |
| PRICE T ROWE ASSOCIATES INC /MD/ |
13F
|
Company |
0.06%
|
27,424
|
$516,000 | — | 30 Sep 2025 | |
| AMERICAN CENTURY COMPANIES INC |
13F
|
Company |
0.06%
|
25,283
|
$475,573 | — | 30 Sep 2025 | |
| Nuveen, LLC |
13F
|
Company |
0.05%
|
23,961
|
$450,706 | — | 30 Sep 2025 | |
| ALLIANCEBERNSTEIN L.P. |
13F
|
Company |
0.05%
|
22,100
|
$415,701 | — | 30 Sep 2025 | |
| TWO SIGMA ADVISERS, LP |
13F
|
Company |
0.05%
|
20,700
|
$389,367 | — | 30 Sep 2025 | |
| WELLS FARGO & COMPANY/MN |
13F
|
Company |
0.04%
|
20,147
|
$378,965 | — | 30 Sep 2025 | |
| Verition Fund Management LLC |
13F
|
Company |
0.04%
|
20,131
|
$378,664 | — | 30 Sep 2025 |
Institutional Holders of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) as of Q4 2025
As of 31 Dec 2025,
Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) was held by
123 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
45,591,200 shares.
The largest 10 holders included
RA CAPITAL MANAGEMENT, L.P., TRV GP V, LLC, Driehaus Capital Management LLC, TRV GP VI, LLC, SAMSARA BIOCAPITAL, LLC, GOLDMAN SACHS GROUP INC, Siren, L.L.C., BlackRock, Inc., BVF INC/IL, and VANGUARD GROUP INC.
This page lists
123
institutional shareholders reporting positions in this security
for the Q4 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
82
Q4 2025 holders
123
Holder diff
41
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 Value $ | Q4 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.