Security key
81734D104
Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN)
CUSIP: 81734D104
Q3 2025 13F Holders as of 30 Sep 2025
- Type / Class
- Equity / Common Stock, $0.001 par value per share
- Shares outstanding
- 45,283,737
- Total 13F shares
- 44,549,033
- Share change
- +129,203
- Total reported value
- $837,968,810
- Put/Call ratio
- 778%
- Price per share
- $18.81
- Number of holders
- 82
- Value change
- +$6,406,374
- Number of buys
- 40
- Number of sells
- 33
Report period
Q3 2025
Institutions
82
Top holders
10
SEPN full security history
Newer quarter: Q4 2025
Previous quarter: Q2 2025
Septerna, Inc. SEC filings
Septerna, Inc. company facts
Broader feeds
Reporting periods
Holder history for CUSIP 81734D104
Recent filing periods:
Top shareholders of SEPN - Septerna, Inc. - Common Stock, $0.001 par value per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| Third Rock Ventures V, L.P. |
3/4/5
13D/G
|
10%+ Owner |
14%
from 13D/G
|
9,368,047
|
$54,803,075 | — | 28 Oct 2024 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
13F
13D/G
|
Company |
10%
from 13D/G
|
4,680,431
|
$49,472,156 | — | 30 Jun 2025 | |
| RA CAPITAL MANAGEMENT, L.P. |
13F
3/4/5
|
Company · Director, 10%+ Owner |
15%
|
6,995,858
|
$73,946,219 | — | 30 Jun 2025 | |
| TRV GP V, LLC |
13F
|
Company |
14%
|
6,215,591
|
$65,698,797 | — | 30 Jun 2025 | |
| BVF INC/IL |
13F
|
Company |
9.7%
|
4,396,124
|
$46,467,031 | — | 30 Jun 2025 | |
| TRV GP VI, LLC |
13F
|
Company |
9.3%
|
4,211,659
|
$44,517,236 | — | 30 Jun 2025 | |
| Samsara BioCapital, LLC |
13F
|
Company |
7%
|
3,149,128
|
$33,286,283 | — | 30 Jun 2025 | |
| Siren, L.L.C. |
13F
|
Individual |
4.9%
|
2,202,514
|
$23,280,573 | — | 30 Jun 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
3.1%
|
1,416,314
|
$14,970,439 | — | 30 Jun 2025 | |
| VANGUARD GROUP INC |
13F
|
Company |
3.1%
|
1,414,363
|
$14,949,817 | — | 30 Jun 2025 | |
| BlackRock, Inc. |
13F
|
Company |
3.1%
|
1,390,800
|
$14,700,756 | — | 30 Jun 2025 | |
| Avoro Capital Advisors LLC |
13F
|
Company |
2.7%
|
1,237,500
|
$13,080,375 | — | 30 Jun 2025 | |
| ADAR1 Capital Management, LLC |
13F
|
Company |
1.9%
|
847,227
|
$8,955,189 | — | 30 Jun 2025 | |
| Checkpoint Capital L.P. |
13F
|
Company |
1.3%
|
586,473
|
$6,199,020 | — | 30 Jun 2025 | |
| Sio Capital Management, LLC |
13F
|
Company |
1.3%
|
584,435
|
$6,177,478 | — | 30 Jun 2025 | |
| Casdin Capital, LLC |
13F
|
Company |
1.2%
|
553,268
|
$5,848,043 | — | 30 Jun 2025 | |
| PERCEPTIVE ADVISORS LLC |
13F
|
Company |
1.2%
|
541,450
|
$5,723,127 | — | 30 Jun 2025 | |
| Venrock Adviser, LLC |
13F
|
Company |
1.2%
|
540,453
|
$5,712,588 | — | 30 Jun 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
1.1%
|
487,956
|
$5,158,405 | — | 30 Jun 2025 | |
| STATE STREET CORP |
13F
|
Company |
0.82%
|
369,992
|
$3,910,815 | — | 30 Jun 2025 | |
| Catalio Capital Management, LP |
13F
|
Company |
0.65%
|
294,360
|
$3,111,385 | — | 30 Jun 2025 | |
| Woodline Partners LP |
13F
|
Company |
0.62%
|
282,585
|
$2,986,923 | — | 30 Jun 2025 | |
| Universal- Beteiligungs- und Servicegesellschaft mbH |
13F
|
Individual |
0.49%
|
222,702
|
$2,353,960 | — | 30 Jun 2025 | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13F
|
Company |
0.37%
|
166,506
|
$1,759,968 | — | 30 Jun 2025 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.34%
|
154,781
|
$1,636,035 | — | 30 Jun 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.34%
|
154,344
|
$1,631,416 | — | 30 Jun 2025 | |
| Deep Track Capital, LP |
13F
|
Company |
0.27%
|
121,716
|
$1,286,538 | — | 30 Jun 2025 | |
| Logos Global Management LP |
13F
|
Company |
0.24%
|
109,202
|
$1,154,265 | — | 30 Jun 2025 | |
| BANK OF AMERICA CORP /DE/ |
13F
|
Company |
0.22%
|
99,213
|
$1,048,682 | — | 30 Jun 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.19%
|
84,860
|
$896,970 | — | 30 Jun 2025 | |
| TWO SIGMA INVESTMENTS, LP |
13F
|
Company |
0.17%
|
77,642
|
$820,676 | — | 30 Jun 2025 | |
| Soleus Capital Management, L.P. |
13F
|
Company |
0.17%
|
75,456
|
$797,570 | — | 30 Jun 2025 | |
| UBS Group AG |
13F
|
Company |
0.16%
|
72,335
|
$764,581 | — | 30 Jun 2025 | |
| Rangeley Capital, LLC |
13F
|
Company |
0.13%
|
58,605
|
$619,455 | — | 30 Jun 2025 | |
| Nuveen, LLC |
13F
|
Company |
0.13%
|
57,971
|
$612,754 | — | 30 Jun 2025 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
0.11%
|
51,944
|
$549,048 | — | 30 Jun 2025 | |
| Bank of New York Mellon Corp |
13F
|
Company |
0.11%
|
48,489
|
$512,528 | — | 30 Jun 2025 | |
| BARCLAYS PLC |
13F
|
Company |
0.08%
|
35,706
|
$377,413 | — | 30 Jun 2025 | |
| Alyeska Investment Group, L.P. |
13F
|
Company |
0.08%
|
35,000
|
$369,950 | — | 30 Jun 2025 | |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
13F
|
Company |
0.06%
|
28,700
|
$303,359 | — | 30 Jun 2025 | |
| RHUMBLINE ADVISERS |
13F
|
Company |
0.06%
|
28,572
|
$301,996 | — | 30 Jun 2025 | |
| PRICE T ROWE ASSOCIATES INC /MD/ |
13F
|
Company |
0.05%
|
24,902
|
$264,000 | — | 30 Jun 2025 | |
| BOOTHBAY FUND MANAGEMENT, LLC |
13F
|
Company |
0.05%
|
24,142
|
$255,181 | — | 30 Jun 2025 | |
| GSA CAPITAL PARTNERS LLP |
13F
|
Company |
0.05%
|
23,527
|
$249,000 | — | 30 Jun 2025 | |
| SIMPLEX TRADING, LLC |
13F
|
Company |
0.05%
|
23,525
|
$248,000 | — | 30 Jun 2025 | |
| XTX Topco Ltd |
13F
|
Company |
0.05%
|
22,330
|
$236,028 | — | 30 Jun 2025 | |
| ALLIANCEBERNSTEIN L.P. |
13F
|
Company |
0.05%
|
22,100
|
$233,597 | — | 30 Jun 2025 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
0.04%
|
17,774
|
$187,871 | — | 30 Jun 2025 | |
| TUDOR INVESTMENT CORP ET AL |
13F
|
Company |
0.04%
|
16,761
|
$177,164 | — | 30 Jun 2025 | |
| WELLS FARGO & COMPANY/MN |
13F
|
Company |
0.03%
|
14,717
|
$155,559 | — | 30 Jun 2025 |
Institutional Holders of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) as of Q3 2025
As of 30 Sep 2025,
Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) was held by
82 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
44,549,033 shares.
The largest 10 holders included
RA CAPITAL MANAGEMENT, L.P., TRV GP V, LLC, Driehaus Capital Management LLC, TRV GP VI, LLC, BVF INC/IL, SAMSARA BIOCAPITAL, LLC, Siren, L.L.C., VANGUARD GROUP INC, BlackRock, Inc., and GOLDMAN SACHS GROUP INC.
This page lists
82
institutional shareholders reporting positions in this security
for the Q3 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q3 2025 vs Q2 2025 Across Filers
Q2 2025 holders
89
Q3 2025 holders
82
Holder diff
-7
| Investor | Q2 2025 Shares | Q3 2025 Shares | Share Diff | Share Chg % | Q2 2025 Value $ | Q3 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.