Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN)
CUSIP: 81734D104
Q2 2025 13F Holders as of 30 Jun 2025
- Type / Class
- Equity / Common Stock, $0.001 par value per share
- Shares outstanding
- 45,283,737
- Total 13F shares
- 44,430,464
- Share change
- -839,913
- Total reported value
- $469,630,218
- Put/Call ratio
- 2727%
- Price per share
- $10.57
- Number of holders
- 89
- Value change
- -$8,199,247
- Number of buys
- 55
- Number of sells
- 25
Quarterly Holders Quick Answers
What is CUSIP 81734D104?
CUSIP 81734D104 identifies SEPN - Septerna, Inc. - Common Stock, $0.001 par value per share in SEC institutional holdings data.
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Recent filing periods for CUSIP 81734D104:
Top shareholders of SEPN - Septerna, Inc. - Common Stock, $0.001 par value per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| Third Rock Ventures VI, L.P. |
3/4/5
|
10%+ Owner |
—
class O/S missing
|
10,427,250
|
$62,553,072 | — | 24 Feb 2025 | |
| Third Rock Ventures V, L.P. |
3/4/5
13D/G
|
10%+ Owner |
14%
from 13D/G
|
9,368,047
|
$54,803,075 | — | 28 Oct 2024 | |
| RA CAPITAL MANAGEMENT, L.P. |
13F
3/4/5
|
Company · Director, 10%+ Owner |
15%
|
6,995,858
|
$40,506,018 | — | 31 Mar 2025 | |
| TRV GP V, LLC |
13F
|
Company |
14%
|
6,215,591
|
$35,988,272 | — | 31 Mar 2025 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
13D/G
13F
|
Company |
10%
|
4,659,911
|
$31,361,201 | +$10,346,049 | 31 May 2025 | |
| BVF INC/IL |
13F
|
Company |
9.7%
|
4,396,124
|
$25,453,558 | — | 31 Mar 2025 | |
| TRV GP VI, LLC |
13F
|
Company |
9.3%
|
4,211,659
|
$24,385,506 | — | 31 Mar 2025 | |
| Samsara BioCapital, LLC |
13F
|
Company |
7%
|
3,149,128
|
$18,233,451 | — | 31 Mar 2025 | |
| Siren, L.L.C. |
13F
|
Individual |
4.9%
|
2,202,514
|
$12,752,556 | — | 31 Mar 2025 | |
| Deep Track Capital, LP |
13F
|
Company |
4.2%
|
1,912,929
|
$11,075,859 | — | 31 Mar 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
3.2%
|
1,449,399
|
$8,392,020 | — | 31 Mar 2025 | |
| Avoro Capital Advisors LLC |
13F
|
Company |
3%
|
1,337,500
|
$7,744,125 | — | 31 Mar 2025 | |
| BlackRock, Inc. |
13F
|
Company |
2.8%
|
1,258,313
|
$7,285,633 | — | 31 Mar 2025 | |
| Catalio Capital Management, LP |
13F
|
Company |
2.3%
|
1,024,245
|
$5,930,379 | — | 31 Mar 2025 | |
| VANGUARD GROUP INC |
13F
|
Company |
2.2%
|
995,044
|
$5,761,305 | — | 31 Mar 2025 | |
| Checkpoint Capital L.P. |
13F
|
Company |
1.8%
|
824,878
|
$4,776,044 | — | 31 Mar 2025 | |
| Sio Capital Management, LLC |
13F
|
Company |
1.7%
|
788,670
|
$4,566,399 | — | 31 Mar 2025 | |
| Soleus Capital Management, L.P. |
13F
|
Company |
1.7%
|
751,353
|
$4,350,334 | — | 31 Mar 2025 | |
| ADAR1 Capital Management, LLC |
13F
|
Company |
1.6%
|
720,848
|
$4,173,710 | — | 31 Mar 2025 | |
| Woodline Partners LP |
13F
|
Company |
1.3%
|
582,585
|
$3,373,167 | — | 31 Mar 2025 | |
| Casdin Capital, LLC |
13F
|
Company |
1.2%
|
553,268
|
$3,203,422 | — | 31 Mar 2025 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
0.96%
|
436,564
|
$2,527,706 | — | 31 Mar 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
0.9%
|
409,640
|
$2,372,287 | — | 31 Mar 2025 | |
| STATE STREET CORP |
13F
|
Company |
0.76%
|
344,604
|
$1,995,257 | — | 31 Mar 2025 | |
| UBS Group AG |
13F
|
Company |
0.53%
|
239,930
|
$1,389,195 | — | 31 Mar 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.35%
|
158,040
|
$915,052 | — | 31 Mar 2025 | |
| Alan Ezekowitz |
3/4/5
|
Director |
—
mixed-class rows
|
134,043
mixed-class rows
|
$813,451 | — | 17 Jun 2025 | |
| Logos Global Management LP |
13F
|
Company |
0.3%
|
134,202
|
$777,030 | — | 31 Mar 2025 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.26%
|
118,451
|
$685,831 | — | 31 Mar 2025 | |
| Universal- Beteiligungs- und Servicegesellschaft mbH |
13F
|
Individual |
0.23%
|
102,749
|
$594,917 | — | 31 Mar 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.2%
|
91,044
|
$527,145 | — | 31 Mar 2025 | |
| TWO SIGMA INVESTMENTS, LP |
13F
|
Company |
0.17%
|
74,841
|
$433,329 | — | 31 Mar 2025 | |
| Stonepine Capital Management, LLC |
13F
|
Company |
0.15%
|
68,084
|
$394,206 | — | 31 Mar 2025 | |
| Ran Xiao |
3/4/5
|
Interim CFO |
—
class O/S missing
|
58,069
|
$339,704 | — | 24 Oct 2024 | |
| Rangeley Capital, LLC |
13F
|
Company |
0.12%
|
52,950
|
$306,581 | — | 31 Mar 2025 | |
| FMR LLC |
13F
|
Company |
0.11%
|
49,778
|
$288,215 | — | 31 Mar 2025 | |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
13F
|
Company |
0.1%
|
44,362
|
$256,856 | — | 31 Mar 2025 | |
| Bank of New York Mellon Corp |
13F
|
Company |
0.08%
|
38,376
|
$222,197 | — | 31 Mar 2025 | |
| CITIGROUP INC |
13F
|
Company |
0.08%
|
38,055
|
$220,339 | — | 31 Mar 2025 | |
| XTX Topco Ltd |
13F
|
Company |
0.08%
|
37,350
|
$216,257 | — | 31 Mar 2025 | |
| Alyeska Investment Group, L.P. |
13F
|
Company |
0.08%
|
35,000
|
$202,650 | — | 31 Mar 2025 | |
| Swiss National Bank |
13F
|
Company |
0.07%
|
30,100
|
$174,279 | — | 31 Mar 2025 | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13F
|
Company |
0.06%
|
25,209
|
$145,960 | — | 31 Mar 2025 | |
| Nuveen, LLC |
13F
|
Company |
0.05%
|
23,961
|
$138,734 | — | 31 Mar 2025 | |
| RHUMBLINE ADVISERS |
13F
|
Company |
0.05%
|
23,318
|
$135,005 | — | 31 Mar 2025 | |
| PRICE T ROWE ASSOCIATES INC /MD/ |
13F
|
Company |
0.05%
|
22,957
|
$133,000 | — | 31 Mar 2025 | |
| BARCLAYS PLC |
13F
|
Company |
0.05%
|
22,733
|
$131,623 | — | 31 Mar 2025 | |
| Lindbrook Capital, LLC |
13F
|
Company |
0.05%
|
21,000
|
$121,590 | — | 31 Mar 2025 | |
| STONERIDGE INVESTMENT PARTNERS LLC |
13F
|
Company |
0.04%
|
18,477
|
$107,000 | — | 31 Mar 2025 | |
| GSA CAPITAL PARTNERS LLP |
13F
|
Company |
0.04%
|
18,299
|
$106,000 | — | 31 Mar 2025 |
Institutional Holders of Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) as of Q2 2025
As of 30 Jun 2025,
Septerna, Inc. - Common Stock, $0.001 par value per share (SEPN) was held by
89 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
44,430,464 shares.
The largest 10 holders included
RA CAPITAL MANAGEMENT, L.P., TRV GP V, LLC, Driehaus Capital Management LLC, BVF INC/IL, TRV GP VI, LLC, SAMSARA BIOCAPITAL, LLC, Siren, L.L.C., GOLDMAN SACHS GROUP INC, VANGUARD GROUP INC, and BlackRock, Inc..
This page lists
89
institutional shareholders reporting positions in this security
for the Q2 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q2 2025 vs Q1 2025 Across Filers
Q1 2025 holders
69
Q2 2025 holders
89
Holder diff
20
| Investor | Q1 2025 Shares | Q2 2025 Shares | Share Diff | Share Chg % | Q1 2025 Value $ | Q2 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.