| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 9.95% | $17.3M | 8.99M | Opaleye Management Inc. | Dec 3, 2025 | |||
| BlackRock, Inc. | 7.2% | $13.8M | 5.98M | BlackRock, Inc. | Mar 31, 2025 | |||
| Aberdeen Group plc | 4.53% | -10.8% | $9.98M | -$266K | 4.09M | -2.59% | Aberdeen Group plc | Oct 1, 2025 |
| Nantahala Capital Management, LLC | 4.26% | $6.83M | 2.97M | Nantahala Capital Management, LLC | Sep 30, 2024 | |||
| FMR LLC | 0.6% | $1.43M | 584K | FMR LLC | Sep 30, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 66M | $161M | -$12.8M | $2.44 | 129 |
| 2025 Q2 | 71.2M | $174M | +$14.6M | $2.44 | 117 |
| 2025 Q1 | 65.2M | $175M | +$930K | $2.69 | 124 |
| 2024 Q4 | 64M | $305M | +$3.09M | $4.77 | 133 |
| 2024 Q3 | 62.9M | $194M | +$33M | $3.08 | 115 |
| 2024 Q2 | 52.5M | $163M | -$4.29M | $3.10 | 117 |
| 2024 Q1 | 53.7M | $187M | -$5.51M | $3.49 | 122 |
| 2023 Q4 | 55.2M | $168M | +$3.19M | $3.05 | 116 |
| 2023 Q3 | 55M | $104M | -$17.8M | $1.89 | 118 |
| 2023 Q2 | 60.9M | $170M | +$1.55M | $2.80 | 121 |
| 2023 Q1 | 59.1M | $244M | -$2.91M | $4.14 | 143 |
| 2022 Q4 | 59.6M | $788M | -$12.7M | $4.66 | 158 |
| 2022 Q3 | 61.1M | $370M | -$40.1M | $6.06 | 161 |
| 2022 Q2 | 64.8M | $679M | -$6.89M | $10.46 | 160 |
| 2022 Q1 | 61.7M | $1.27B | -$101M | $20.62 | 151 |
| 2021 Q4 | 67.1M | $2.09B | +$74.4M | $31.27 | 169 |
| 2021 Q3 | 63.1M | $1.47B | -$5.91M | $23.26 | 153 |
| 2021 Q2 | 63.4M | $1.44B | +$28.6M | $22.66 | 141 |
| 2021 Q1 | 62.2M | $1.42B | +$27.9M | $22.89 | 150 |
| 2020 Q4 | 61M | $1.33B | +$148M | $21.83 | 149 |
| 2020 Q3 | 54.1M | $635M | +$756K | $11.74 | 125 |
| 2020 Q2 | 54.1M | $616M | -$9.74M | $11.40 | 123 |
| 2020 Q1 | 55M | $613M | +$35.2M | $11.16 | 116 |
| 2019 Q4 | 51.1M | $818M | +$18.9M | $15.99 | 120 |
| 2019 Q3 | 49.7M | $681M | -$37.3M | $13.72 | 116 |
| 2019 Q2 | 50.7M | $928M | +$71.9M | $18.43 | 121 |
| 2019 Q1 | 46.6M | $958M | +$11.1M | $20.53 | 125 |
| 2018 Q4 | 46.2M | $771M | +$46.2M | $16.70 | 122 |
| 2018 Q3 | 43.4M | $744M | +$37M | $17.15 | 110 |
| 2018 Q2 | 41.3M | $594M | +$90.2M | $14.40 | 100 |
| 2018 Q1 | 35.1M | $386M | +$11.2M | $11.00 | 79 |
| 2017 Q4 | 34.3M | $286M | +$20.6M | $8.35 | 73 |
| 2017 Q3 | 31.8M | $211M | +$6.88M | $6.65 | 62 |
| 2017 Q2 | 30.7M | $168M | +$33.3M | $5.45 | 56 |
| 2017 Q1 | 24.6M | $118M | +$14.2M | $4.80 | 55 |
| 2016 Q4 | 24.2M | $111M | +$2.23M | $4.60 | 58 |
| 2016 Q3 | 23.6M | $105M | +$181K | $4.44 | 60 |
| 2016 Q2 | 23.6M | $95M | +$14.3M | $4.03 | 55 |
| 2016 Q1 | 20.2M | $62.7M | +$2.22M | $3.11 | 47 |
| 2015 Q4 | 13.9M | $58.6M | +$3.5M | $4.23 | 46 |
| 2015 Q3 | 13.1M | $44.3M | +$2.42M | $3.39 | 46 |
| 2015 Q2 | 12.3M | $47.7M | +$6.22M | $3.89 | 49 |
| 2015 Q1 | 10.7M | $48.8M | +$5.4M | $4.56 | 40 |
| 2014 Q4 | 9.77M | $24.6M | -$2.05M | $2.52 | 34 |
| 2014 Q3 | 10.6M | $24.5M | +$1.6M | $2.33 | 33 |
| 2014 Q2 | 10.6M | $15.4M | +$324K | $1.46 | 31 |
| 2014 Q1 | 10.3M | $21.1M | +$2.03M | $2.04 | 33 |