| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 9.95% | $17,346,819 | 8,987,989 | Opaleye Management Inc. | 03 Dec 2025 | |||
| BlackRock, Inc. | 7.2% | $13,752,804 | 5,979,480 | BlackRock, Inc. | 31 Mar 2025 | |||
| Aberdeen Group plc | 4.53% | -11% | $9,984,631 | -$265,687 | 4,092,062 | -2.6% | Aberdeen Group plc | 01 Oct 2025 |
| Nantahala Capital Management, LLC | 4.26% | $6,825,958 | 2,967,808 | Nantahala Capital Management, LLC | 30 Sep 2024 | |||
| FMR LLC | 0.6% | $1,425,855 | 584,367 | FMR LLC | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 65,969,954 | $160,958,513 | -$12,809,765 | $2.44 | 129 |
| 2025 Q2 | 71,218,652 | $173,772,833 | +$14,555,678 | $2.44 | 117 |
| 2025 Q1 | 65,178,959 | $175,225,389 | +$929,989 | $2.69 | 124 |
| 2024 Q4 | 63,988,678 | $305,316,642 | +$3,089,141 | $4.77 | 133 |
| 2024 Q3 | 62,919,076 | $193,796,579 | +$32,967,849 | $3.08 | 115 |
| 2024 Q2 | 52,477,224 | $162,676,431 | -$4,430,246 | $3.1 | 117 |
| 2024 Q1 | 53,718,149 | $187,413,304 | -$5,510,895 | $3.49 | 123 |
| 2023 Q4 | 55,230,099 | $168,449,151 | +$3,188,960 | $3.05 | 117 |
| 2023 Q3 | 55,050,956 | $104,041,277 | -$17,760,919 | $1.89 | 119 |
| 2023 Q2 | 60,904,680 | $170,515,502 | +$1,545,759 | $2.8 | 122 |
| 2023 Q1 | 59,089,040 | $244,372,878 | -$3,021,145 | $4.14 | 144 |
| 2022 Q4 | 59,636,802 | $788,383,480 | -$13,405,240 | $4.66 | 161 |
| 2022 Q3 | 61,301,294 | $371,491,238 | -$40,070,138 | $6.06 | 164 |
| 2022 Q2 | 64,991,812 | $680,516,879 | -$6,800,772 | $10.46 | 162 |
| 2022 Q1 | 61,863,148 | $1,274,964,586 | -$98,934,303 | $20.62 | 151 |
| 2021 Q4 | 67,147,021 | $2,095,342,832 | +$76,348,853 | $31.27 | 170 |
| 2021 Q3 | 63,138,366 | $1,471,997,186 | -$5,907,120 | $23.26 | 152 |
| 2021 Q2 | 63,445,130 | $1,435,375,799 | +$28,573,787 | $22.66 | 141 |
| 2021 Q1 | 62,157,382 | $1,422,750,683 | +$27,881,773 | $22.89 | 150 |
| 2020 Q4 | 61,031,096 | $1,332,428,797 | +$147,547,692 | $21.83 | 149 |
| 2020 Q3 | 54,143,314 | $635,384,057 | +$756,055 | $11.74 | 125 |
| 2020 Q2 | 54,090,083 | $615,832,306 | -$9,739,461 | $11.4 | 123 |
| 2020 Q1 | 54,973,182 | $613,470,073 | +$35,167,629 | $11.16 | 116 |
| 2019 Q4 | 51,136,893 | $817,632,585 | +$18,855,885 | $15.99 | 120 |
| 2019 Q3 | 49,670,282 | $681,242,929 | -$37,267,524 | $13.72 | 116 |
| 2019 Q2 | 50,745,755 | $928,253,177 | +$71,892,883 | $18.43 | 121 |
| 2019 Q1 | 46,639,678 | $957,504,084 | +$11,137,897 | $20.53 | 122 |
| 2018 Q4 | 46,184,102 | $771,318,098 | +$46,246,024 | $16.7 | 119 |
| 2018 Q3 | 43,408,808 | $744,445,459 | +$36,964,971 | $17.15 | 108 |
| 2018 Q2 | 41,280,432 | $594,459,182 | +$90,212,376 | $14.4 | 99 |
| 2018 Q1 | 35,090,414 | $385,990,722 | +$11,240,688 | $11 | 79 |
| 2017 Q4 | 34,306,430 | $286,457,460 | +$20,633,224 | $8.35 | 73 |
| 2017 Q3 | 31,764,185 | $211,226,933 | +$6,875,107 | $6.65 | 62 |
| 2017 Q2 | 30,740,171 | $167,534,547 | +$33,321,129 | $5.45 | 56 |
| 2017 Q1 | 24,570,510 | $117,934,000 | +$14,219,009 | $4.8 | 55 |
| 2016 Q4 | 24,154,209 | $111,107,286 | +$2,230,034 | $4.6 | 58 |
| 2016 Q3 | 23,606,886 | $104,808,783 | +$180,655 | $4.44 | 60 |
| 2016 Q2 | 23,568,734 | $94,983,002 | +$14,252,595 | $4.03 | 55 |
| 2016 Q1 | 20,217,995 | $62,878,000 | +$2,277,261 | $3.11 | 50 |
| 2015 Q4 | 13,854,689 | $58,596,699 | +$3,498,720 | $4.23 | 46 |
| 2015 Q3 | 13,064,117 | $44,279,501 | +$2,421,990 | $3.39 | 46 |
| 2015 Q2 | 12,291,372 | $47,805,344 | +$6,217,663 | $3.89 | 50 |
| 2015 Q1 | 10,707,704 | $48,822,000 | +$5,406,301 | $4.56 | 40 |
| 2014 Q4 | 9,767,724 | $24,611,000 | -$2,044,811 | $2.52 | 33 |
| 2014 Q3 | 10,622,351 | $24,528,700 | +$1,600,542 | $2.33 | 33 |
| 2014 Q2 | 10,560,796 | $15,419,009 | +$324,151 | $1.46 | 31 |
| 2014 Q1 | 10,329,923 | $21,081,175 | +$2,030,404 | $2.04 | 34 |