Praxis Precision Medicines, Inc. - Common Stock, par value $0.0001 per share (PRAX)

Q: What does CUSIP 74006W207 represent in this 13F holders report?

CUSIP 74006W207 is the security identifier for PRAX - Praxis Precision Medicines, Inc. - Common Stock, par value $0.0001 per share used to aggregate holder disclosures.

Q: How many institutions held PRAX - Praxis Precision Medicines, Inc. - Common Stock, par value $0.0001 per share in Q1 2026?

288 institutional investors reported PRAX - Praxis Precision Medicines, Inc. - Common Stock, par value $0.0001 per share for Q1 2026. Use the holders table for investor-level position and value details.

CUSIP: 74006W207

Q1 2026 13F Holders as of 31 Mar 2026

Security type / class: Equity / Common Stock, par value $0.0001 per share
Total 13F shares: 31,791,698
Total 13F value: $10,236,102,894
Share change: +1,460,908
Put/Call ratio: 361%
SEC-reported price per share: $322.19
Number of holders: 288
Value change: +$502,648,841
Number of buys: 190
Number of sells: 100
Shares outstanding: 27,828,540

Security key

74006W207

Report period

Q1 2026

Institutions

288

Top holders

PRAX full security history Ownership snapshot Full 13F holder table Newer quarter: Q2 2026 Praxis Precision Medicines, Inc. SEC filings Praxis Precision Medicines, Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 74006W207

Newer quarter: Q2 2026

Recent filing periods:

Q2 2026

Ownership snapshot

Top reported holders of PRAX - Praxis Precision Medicines, Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

Janus Henderson Group Ltd.

Disclosed value leader

Janus Henderson Group Ltd.

Comparable rows

15/15

Latest evidence

31 Mar 2026

13F 13D/G 3/4/5 Lead comparable stake: 12% 13D/G row: Janus Henderson Group Ltd. Showing 1-6 of 15 holder rows.

Quick read

Janus Henderson Group Ltd. leads the comparable SEC ownership view at 12%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens Janus Henderson Group Ltd.'s linked filing trail.

Comparable ownership Top 5

Janus Henderson Group Ltd. 12%

ORBIS INVESTMENT MANAGEMENT LTD 8.9%

FMR LLC 7.7%

PERCEPTIVE ADVISORS LLC 7.2%

BAKER BROS. ADVISORS LP 6.3%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Janus Henderson Group Ltd.	13F 13D/G Company · JANUS HENDERSON GROUP PLC 13F 13D/G	12% from 13D/G	$954,833,974 3,240,086 shares	—	31 Dec 2025
ORBIS INVESTMENT MANAGEMENT LTD	13D/G 13D/G	8.9%	$795,297,984 2,468,413 shares	+$391,731,490	31 Mar 2026
FMR LLC	13D/G 13F Company 13D/G 13F	7.7%	$694,752,222 2,156,343 shares	+$258,740,479	31 Mar 2026
PERCEPTIVE ADVISORS LLC	13F 13D/G Company 13F 13D/G	7.2% from 13D/G	$588,296,914 1,995,986 shares	—	31 Dec 2025
BAKER BROS. ADVISORS LP	13D/G 13F Company 13D/G 13F	6.3%	$564,862,864 1,753,198 shares	$0	31 Mar 2026
VANGUARD CAPITAL MANAGEMENT LLC	13D/G Vanguard Capital Management 13D/G	5.1%	$457,291,677 1,419,323 shares	$0	31 Mar 2026

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q1 2026

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

288

31,791,698

Rows available

288

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q1 2026 vs Q1 2026 Across Filers

Q1 2026 holders

288

Q1 2026 holders

288

Holder diff

Investor	Q1 2026 Shares	Q1 2026 Shares	Share Diff	Share Chg %	Q1 2026 value	Q1 2026 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend