Praxis Precision Medicines, Inc. - Common Stock (PRAX)
CUSIP: 74006W207
Q4 2025 13F Holders as of 31 Dec 2025
- Type / Class
- Equity / Common Stock
- Shares outstanding
- 25,726,377
- Total 13F shares
- 29,469,040
- Share change
- +4,707,059
- Total reported value
- $8,685,915,974
- Put/Call ratio
- 106%
- Price per share
- $294.74
- Number of holders
- 247
- Value change
- +$1,516,157,215
- Number of buys
- 189
- Number of sells
- 59
Quarterly Holders Quick Answers
What is CUSIP 74006W207?
CUSIP 74006W207 identifies PRAX - Praxis Precision Medicines, Inc. - Common Stock in SEC institutional holdings data.
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Recent filing periods for CUSIP 74006W207:
Top shareholders of PRAX - Praxis Precision Medicines, Inc. - Common Stock (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC |
13D/G
13F
|
Company |
7.2%
|
1,995,986
|
$575,742,162 | +$182,728,171 | 31 Dec 2025 | |
| Point72 Asset Management, L.P. |
13D/G
13F
|
Steven A. Cohen · Company |
6.1%
|
1,569,309
|
$452,667,181 | -$145,274,958 | 31 Dec 2025 | |
| FMR LLC |
13D/G
13F
|
Company |
5.4%
|
1,353,275
|
$398,864,288 | $0 | 31 Dec 2025 | |
| ORBIS INVESTMENT MANAGEMENT LTD |
13D/G
|
— |
5%
|
1,252,573
|
$361,304,682 | $0 | 31 Dec 2025 | |
| Adage Capital Management, L.P. |
3/4/5
13D/G
|
10%+ Owner |
3.8%
from 13D/G
|
4,434,260
mixed-class rows
|
$288,424,500 | +$33,198,124 | 16 Oct 2025 | |
| JANUS HENDERSON GROUP PLC |
13D/G
13F
|
Company |
12%
|
2,763,859
|
$146,484,527 | +$12,214,062 | 30 Sep 2025 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
13F
|
Company |
9.2%
|
2,374,085
|
$125,826,505 | — | 30 Sep 2025 | |
| Clarus Lifesciences III, L.P. |
3/4/5
|
10%+ Owner |
—
class O/S missing
|
4,894,109
|
$123,282,606 | — | 12 May 2021 | |
| BlackRock, Inc. |
13F
|
Company |
7%
|
1,801,080
|
$95,457,240 | — | 30 Sep 2025 | |
| VANGUARD GROUP INC |
13F
|
Company |
4.9%
|
1,267,286
|
$67,166,158 | — | 30 Sep 2025 | |
| PRICE T ROWE ASSOCIATES INC /MD/ |
13D/G
13F
|
T. Rowe Price Associates, Inc. · Company |
4.8%
|
1,003,545
|
$53,187,885 | $0 | 30 Sep 2025 | |
| Cormorant Asset Management, LP |
13D/G
13F
|
Company |
4%
|
1,000,000
|
$53,000,000 | -$33,125,000 | 30 Sep 2025 | |
| STATE STREET CORP |
13F
|
Company |
3.5%
|
907,108
|
$48,076,724 | — | 30 Sep 2025 | |
| Soleus Capital Management, L.P. |
13F
|
Company |
3.3%
|
859,166
|
$45,535,798 | — | 30 Sep 2025 | |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
13F
|
Company |
3.3%
|
840,851
|
$44,565,103 | — | 30 Sep 2025 | |
| Soleus Capital Master Fund, L.P. |
13D/G
|
— |
4.6%
|
966,740
|
$40,651,514 | -$2,144,555 | 30 Jun 2025 | |
| Venrock Healthcare Capital Partners III, L.P. |
13D/G
|
— |
4.9%
|
1,016,497
|
$37,813,688 | -$6,466,960 | 31 Mar 2025 | |
| BAKER BROS. ADVISORS LP |
13F
|
Company |
2.7%
|
689,488
|
$36,542,864 | — | 30 Sep 2025 | |
| MORGAN STANLEY |
13F
13D/G
|
Company |
2.9%
from 13D/G
|
643,495
|
$34,105,272 | — | 30 Sep 2025 | |
| Capital Research Global Investors |
13D/G
|
— |
4.2%
|
853,746
|
$31,759,351 | $0 | 31 Mar 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
2.3%
|
593,021
|
$31,430,113 | — | 30 Sep 2025 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
13F
|
Company |
1.9%
|
500,551
|
$26,529,203 | — | 30 Sep 2025 | |
| BANK OF AMERICA CORP /DE/ |
13F
|
Company |
1.9%
|
482,861
|
$25,591,633 | — | 30 Sep 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
1.8%
|
457,032
|
$24,226,192 | — | 30 Sep 2025 | |
| Woodline Partners LP |
13F
|
Company |
1.6%
|
417,669
|
$22,136,457 | — | 30 Sep 2025 | |
| Assenagon Asset Management S.A. |
13F
|
Company |
1.6%
|
409,779
|
$21,718,287 | — | 30 Sep 2025 | |
| CIBC Asset Management Inc |
13F
|
Company |
1.5%
|
388,759
|
$20,604,227 | — | 30 Sep 2025 | |
| FRANKLIN RESOURCES INC |
13F
|
Company |
1.2%
|
314,157
|
$16,650,321 | — | 30 Sep 2025 | |
| Vivo Capital, LLC |
13F
|
Company |
0.77%
|
198,895
|
$10,541,435 | — | 30 Sep 2025 | |
| Sofinnova Investments, Inc. |
13F
|
Company |
0.67%
|
172,833
|
$9,160,149 | — | 30 Sep 2025 | |
| 5AM Venture Management, LLC |
13F
|
Company |
0.66%
|
170,000
|
$9,010,000 | — | 30 Sep 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.65%
|
168,353
|
$8,922,709 | — | 30 Sep 2025 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.63%
|
161,661
|
$8,568,033 | — | 30 Sep 2025 | |
| ALGERT GLOBAL LLC |
13F
|
Company |
0.63%
|
160,818
|
$8,523,000 | — | 30 Sep 2025 | |
| Alyeska Investment Group, L.P. |
13F
|
Company |
0.55%
|
141,516
|
$7,500,348 | — | 30 Sep 2025 | |
| Velan Capital Investment Management LP |
13F
|
Company |
0.52%
|
132,805
|
$7,038,665 | — | 30 Sep 2025 | |
| Logos Global Management LP |
13F
|
Company |
0.49%
|
125,000
|
$6,625,000 | — | 30 Sep 2025 | |
| READYSTATE ASSET MANAGEMENT LP |
13F
|
Company |
0.42%
|
109,177
|
$5,786,381 | — | 30 Sep 2025 | |
| Exome Asset Management LLC |
13F
|
Company |
0.4%
|
101,996
|
$5,405,788 | — | 30 Sep 2025 | |
| UBS Group AG |
13F
|
Company |
0.38%
|
96,812
|
$5,131,036 | — | 30 Sep 2025 | |
| HighVista Strategies LLC |
13F
|
Company |
0.37%
|
95,002
|
$5,035,106 | — | 30 Sep 2025 | |
| BARCLAYS PLC |
13F
|
Company |
0.3%
|
76,637
|
$4,061,761 | — | 30 Sep 2025 | |
| KENNEDY CAPITAL MANAGEMENT LLC |
13F
|
Company |
0.3%
|
76,218
|
$4,039,554 | — | 30 Sep 2025 | |
| Tri Locum Partners LP |
13F
|
Company |
0.3%
|
75,986
|
$4,027,258 | — | 30 Sep 2025 | |
| MARSHALL WACE, LLP |
13F
|
Company |
0.26%
|
68,141
|
$3,611,473 | — | 30 Sep 2025 | |
| 72 Investment Holdings, LLC |
13F
|
Company |
0.26%
|
65,933
|
$3,494,449 | — | 30 Sep 2025 | |
| S.c.a. Candriam |
13F
|
Individual |
0.24%
|
62,866
|
$3,331,898 | — | 30 Sep 2025 | |
| WELLINGTON MANAGEMENT GROUP LLP |
13F
|
Company |
0.24%
|
61,241
|
$3,245,773 | — | 30 Sep 2025 | |
| PFM Health Sciences, LP |
13F
|
Company |
0.24%
|
60,578
|
$3,210,634 | — | 30 Sep 2025 | |
| SPHERA FUNDS MANAGEMENT LTD. |
13F
|
Company |
0.23%
|
57,901
|
$3,068,753 | — | 30 Sep 2025 |
Institutional Holders of Praxis Precision Medicines, Inc. - Common Stock (PRAX) as of Q4 2025
As of 31 Dec 2025,
Praxis Precision Medicines, Inc. - Common Stock (PRAX) was held by
247 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
29,469,040 shares.
The largest 10 holders included
JANUS HENDERSON GROUP PLC, BlackRock, Inc., PERCEPTIVE ADVISORS LLC, VANGUARD GROUP INC, FMR LLC, Orbis Allan Gray Ltd, BAKER BROS. ADVISORS LP, ADAGE CAPITAL PARTNERS GP, L.L.C., Cormorant Asset Management, LP, and Driehaus Capital Management LLC.
This page lists
247
institutional shareholders reporting positions in this security
for the Q4 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
150
Q4 2025 holders
247
Holder diff
97
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 Value $ | Q4 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.