| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 14% | +68% | $15,073,429 | +$10,306,134 | 2,304,242 | +216% | T. Rowe Price Investment Management, Inc. | 31 Oct 2025 |
| Affinity Asset Advisors, LLC | 8.6% | +9.6% | $12,870,974 | +$7,880,460 | 1,713,092 | +158% | Affinity Asset Advisors, LLC | 22 Jan 2026 |
| Opaleye Management Inc. | 9.5% | $10,262,842 | 1,569,002 | Opaleye Management Inc. | 10 Oct 2025 | |||
| INTEGRATED CORE STRATEGIES (US) LLC | 5.5% | $7,252,280 | 1,008,662 | Millennium Management LLC | 04 Feb 2026 | |||
| J. WOOD CAPITAL ADVISORS LLC | 5% | $6,546,231 | 1,000,708 | J. Wood Capital Advisors LLC | 14 Oct 2025 | |||
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 4.9% | $4,250,895 | 649,984 | HIGHBRIDGE CAPITAL MANAGEMENT, LLC | 30 Sep 2025 | |||
| Adage Capital Management, L.P. | 2.4% | $3,140,132 | 436,736 | Adage Capital Management, L.P. | 31 Dec 2025 | |||
| JPMORGAN CHASE & CO | 4.9% | -6% | $2,797,089 | -$149,213 | 427,624 | -5.1% | JPMORGAN CHASE & CO. | 30 Sep 2025 |
| VANGUARD GROUP INC | 4.7% | $2,670,221 | 408,222 | The Vanguard Group | 30 Sep 2025 |
As of 31 Dec 2025, 36 institutional investors reported holding 3,638,837 shares of Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI). This represents 20% of the company’s total 18,350,252 outstanding shares.
The largest institutional shareholders of Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI) together control 20% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | 4.8% | 889,575 | 0.47% | $6,547,272 | |
| VANGUARD GROUP INC | 3% | 559,619 | +37% | 0% | $4,118,796 |
| Soleus Capital Management, L.P. | 2.4% | 440,000 | 0.14% | $3,238,400 | |
| Exome Asset Management LLC | 1.6% | 295,541 | 1.1% | $2,175,182 | |
| BlackRock, Inc. | 1.3% | 247,558 | +6.7% | 0% | $1,822,026 |
| GEODE CAPITAL MANAGEMENT, LLC | 1% | 187,734 | +101% | 0% | $1,381,872 |
| Avidity Partners Management LP | 0.73% | 134,566 | 0% | 0.29% | $990,406 |
| MARSHALL WACE, LLP | 0.7% | 128,451 | 0% | 0% | $945,400 |
| GROUP ONE TRADING LLC | 0.56% | 102,419 | +50% | 0.02% | $753,804 |
| C WorldWide Group Holding A/S | 0.54% | 100,000 | 0% | 0.01% | $736,000 |
| Walleye Capital LLC | 0.52% | 95,672 | 0% | $704,146 | |
| UBS Group AG | 0.48% | 88,455 | +48% | 0% | $651,029 |
| Context Capital Management, LLC | 0.34% | 62,995 | 0.01% | $463,643 | |
| RENAISSANCE TECHNOLOGIES LLC | 0.33% | 59,914 | -7.4% | 0% | $440,967 |
| STATE STREET CORP | 0.32% | 58,942 | +27% | 0% | $433,813 |
| Connor, Clark & Lunn Investment Management Ltd. | 0.31% | 57,212 | 0% | $421,080 | |
| JANE STREET GROUP, LLC | 0.19% | 35,533 | 0% | $261,523 | |
| SIMPLEX TRADING, LLC | 0.18% | 32,868 | +461% | 0.01% | $241,908 |
| Baird Financial Group, Inc. | 0.15% | 27,993 | +7.9% | 0% | $206,028 |
| Bank of New York Mellon Corp | 0.06% | 11,087 | +0.01% | 0% | $81,598 |
| MORGAN STANLEY | 0.05% | 8,858 | -66% | 0% | $65,194 |
| BARCLAYS PLC | 0.02% | 4,109 | 0% | 0% | $30,242 |
| ACADIAN ASSET MANAGEMENT LLC | 0.02% | 3,726 | 0% | $27,000 | |
| TD Waterhouse Canada Inc. | 0.02% | 3,203 | 0% | 0% | $23,510 |
| JPMORGAN CHASE & CO | 0.01% | 1,741 | +217% | 0% | $12,814 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 3,638,837 | $26,781,502 | +$16,027,903 | $7.36 | 36 |
| 2025 Q3 | 2,947,949 | $19,279,960 | -$7,678,877 | $6.54 | 51 |
| 2025 Q2 | 4,384,748 | $18,898,424 | +$4,718,131 | $4.31 | 49 |
| 2025 Q1 | 3,312,099 | $12,386,156 | +$12,277,831 | $3.74 | 47 |