| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 12% | -14% | $16,137,387 | -$430,113 | 2,244,421 | -2.6% | T. Rowe Price Investment Management, Inc. | 31 Dec 2025 |
| Affinity Asset Advisors, LLC | 8.6% | +9.6% | $12,870,974 | +$7,880,460 | 1,713,092 | +158% | Affinity Asset Advisors, LLC | 22 Jan 2026 |
| Opaleye Management Inc. | 9.5% | $10,262,842 | 1,569,002 | Opaleye Management Inc. | 10 Oct 2025 | |||
| INTEGRATED CORE STRATEGIES (US) LLC | 5.5% | $7,252,280 | 1,008,662 | Millennium Management LLC | 04 Feb 2026 | |||
| J. WOOD CAPITAL ADVISORS LLC | 5% | $6,546,231 | 1,000,708 | J. Wood Capital Advisors LLC | 14 Oct 2025 | |||
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 4.9% | $4,250,895 | 649,984 | HIGHBRIDGE CAPITAL MANAGEMENT, LLC | 30 Sep 2025 | |||
| Adage Capital Management, L.P. | 2.4% | $3,140,132 | 436,736 | Adage Capital Management, L.P. | 31 Dec 2025 | |||
| JPMORGAN CHASE & CO | 4.9% | -6% | $2,797,089 | -$149,213 | 427,624 | -5.1% | JPMORGAN CHASE & CO. | 30 Sep 2025 |
| VANGUARD GROUP INC | 4.7% | $2,670,221 | 408,222 | The Vanguard Group | 30 Sep 2025 |
As of 31 Dec 2025, 67 institutional investors reported holding 8,006,080 shares of Karyopharm Therapeutics Inc. - COMMON STOCK (KPTI). This represents 42% of the company’s total 19,020,517 outstanding shares.
The largest institutional shareholders of Karyopharm Therapeutics Inc. - COMMON STOCK (KPTI) together control 37% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Opaleye Management Inc. | 4.9% | 930,000 | 0.91% | $6,844,800 | |
| Affinity Asset Advisors, LLC | 4.7% | 889,575 | 0.47% | $6,547,272 | |
| T. Rowe Price Investment Management, Inc. | 3.1% | 585,908 | -16% | 0% | $4,313,000 |
| VANGUARD GROUP INC | 2.9% | 559,619 | +37% | 0% | $4,118,796 |
| Soleus Capital Management, L.P. | 2.3% | 440,000 | 0.14% | $3,238,400 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.2% | 421,322 | 0% | 0% | $3,100,930 |
| Davidson Kempner Capital Management LP | 1.6% | 310,020 | 0.05% | $2,281,747 | |
| BRAIDWELL LP | 1.6% | 303,370 | 0.07% | $2,232,803 | |
| Exome Asset Management LLC | 1.6% | 295,541 | 1.1% | $2,175,182 | |
| AMERIPRISE FINANCIAL INC | 1.5% | 276,881 | 0% | $2,037,844 | |
| Boxer Capital Management, LLC | 1.3% | 252,536 | 0.41% | $1,858,665 | |
| BlackRock, Inc. | 1.3% | 247,558 | +6.7% | 0% | $1,822,026 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.99% | 187,734 | +101% | 0% | $1,381,872 |
| TWO SIGMA INVESTMENTS, LP | 0.78% | 148,793 | 0% | $1,095,116 | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.78% | 147,698 | +318% | 0% | $1,087,057 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.76% | 144,628 | 0.03% | $1,064,462 | |
| Catalio Capital Management, LP | 0.75% | 142,984 | 0% | 0.2% | $1,052,362 |
| Avidity Partners Management LP | 0.71% | 134,566 | 0% | 0.29% | $990,406 |
| MARSHALL WACE, LLP | 0.68% | 128,451 | 0% | 0% | $945,400 |
| GROUP ONE TRADING LLC | 0.54% | 102,419 | +50% | 0.02% | $753,804 |
| C WorldWide Group Holding A/S | 0.53% | 100,000 | 0% | 0.01% | $736,000 |
| Walleye Capital LLC | 0.5% | 95,672 | 0% | $704,146 | |
| TWO SIGMA ADVISERS, LP | 0.47% | 89,729 | 0% | $660,405 | |
| UBS Group AG | 0.47% | 88,455 | +48% | 0% | $651,029 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0.35% | 65,873 | +89% | 0.01% | $484,825 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 8,006,080 | $58,926,279 | +$37,473,437 | $7.36 | 67 |
| 2025 Q3 | 2,947,949 | $19,279,960 | -$7,678,877 | $6.54 | 51 |
| 2025 Q2 | 4,384,748 | $18,898,424 | +$4,718,131 | $4.31 | 49 |
| 2025 Q1 | 3,312,099 | $12,386,156 | +$12,277,831 | $3.74 | 47 |