Latest Period
Q4 2025
Security Snapshot
Karyopharm Therapeutics Inc. - COMMON STOCK (KPTI) Institutional Ownership
CUSIP: 48576U205
13F Institutional Holders and Ownership History from Q1 2025 to Q1 2026
Institutions Reporting
68
Shares (Excl. Options)
9,456,135
Price
$7.36
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- Type / Class
- Equity / COMMON STOCK
- Symbol
- KPTI on Nasdaq
- Shares outstanding
- 19,020,517
- Price per share
- $8.28
- All holders as of 31 Dec 2025
- Q4 2025
- Total 13F shares
- 9,456,135
- Total reported value
- $69,598,197
- % of total 13F portfolios
- 0%
- Share change
- +6,508,186
- Value change
- +$47,945,529
- Number of holders
- 68
- Price from insider filings
- $8.28
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors
Quick Takeaways
- KPTI - Karyopharm Therapeutics Inc. - COMMON STOCK is tracked under CUSIP 48576U205.
- 68 institutions reported positions in Q4 2025.
- 9 significant owners is listed from Schedule 13D/13G reporting.
What Changed
- Holder count moved from 68 to 9 between Q4 2025 and Q1 2026.
- Reported value moved from $69,598,197 to $1,379,525.
Why This Matters
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Source Evidence
Source: SEC Form 13F
Open SEC Evidence
Latest holder context comes from 68 institutions filings for Q4 2025.
Investment Quick Answers
What is CUSIP 48576U205?
CUSIP 48576U205 identifies KPTI - Karyopharm Therapeutics Inc. - COMMON STOCK in SEC 13F datasets.
Where can I see the latest institutional holders?
Review the Q4 2025 holders report and the ownership history table below.
Next ownership checks
Use the next link that matches the question you still need to answer about this security.
- Latest 13F filings when you want to inspect fresh institutional portfolio moves.
- Latest Schedule 13D/13G reports when you need large-owner changes outside the 13F cycle.
- All institutional ownership pages to compare this security with other holder-history pages.
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 48576U205:
Significant Owners of Karyopharm Therapeutics Inc. - COMMON STOCK (KPTI) based on Schedule 13D/G filings
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 12% | -14% | $16,137,387 | -$430,113 | 2,244,421 | -2.6% | T. Rowe Price Investment Management, Inc. | 31 Dec 2025 |
| Affinity Asset Advisors, LLC | 8.6% | +9.6% | $12,870,974 | +$7,880,460 | 1,713,092 | +158% | Affinity Asset Advisors, LLC | 22 Jan 2026 |
| Opaleye Management Inc. | 9.5% | $10,262,842 | 1,569,002 | Opaleye Management Inc. | 10 Oct 2025 | |||
| INTEGRATED CORE STRATEGIES (US) LLC | 5.5% | $7,252,280 | 1,008,662 | Millennium Management LLC | 04 Feb 2026 | |||
| J. WOOD CAPITAL ADVISORS LLC | 5% | $6,546,231 | 1,000,708 | J. Wood Capital Advisors LLC | 14 Oct 2025 | |||
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 4.9% | $4,250,895 | 649,984 | HIGHBRIDGE CAPITAL MANAGEMENT, LLC | 30 Sep 2025 | |||
| Adage Capital Management, L.P. | 2.4% | $3,140,132 | 436,736 | Adage Capital Management, L.P. | 31 Dec 2025 | |||
| JPMORGAN CHASE & CO | 4.9% | -6% | $2,797,089 | -$149,213 | 427,624 | -5.1% | JPMORGAN CHASE & CO. | 30 Sep 2025 |
| VANGUARD GROUP INC | 4.7% | $2,670,221 | 408,222 | The Vanguard Group | 30 Sep 2025 |
As of 31 Dec 2025, 68 institutional investors reported holding 9,456,135 shares of Karyopharm Therapeutics Inc. - COMMON STOCK (KPTI). This represents 50% of the company’s total 19,020,517 outstanding shares.
Top 25 Institutional Shareholders
The largest institutional shareholders of Karyopharm Therapeutics Inc. - COMMON STOCK (KPTI) together control 45% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 7.8% | 1,491,409 | +113% | 0.01% | $10,977,000 |
| Opaleye Management Inc. | 4.9% | 930,000 | 0.91% | $6,844,800 | |
| Affinity Asset Advisors, LLC | 4.7% | 889,575 | 0.47% | $6,547,272 | |
| VANGUARD GROUP INC | 2.9% | 559,619 | +37% | 0% | $4,118,796 |
| Ikarian Capital, LLC | 2.9% | 544,554 | +1898% | 0.52% | $4,007,918 |
| Soleus Capital Management, L.P. | 2.3% | 440,000 | 0.14% | $3,238,400 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.2% | 421,322 | 0% | 0% | $3,100,930 |
| Davidson Kempner Capital Management LP | 1.6% | 310,020 | 0.05% | $2,281,747 | |
| BRAIDWELL LP | 1.6% | 303,370 | 0.07% | $2,232,803 | |
| Exome Asset Management LLC | 1.6% | 295,541 | 1.1% | $2,175,182 | |
| AMERIPRISE FINANCIAL INC | 1.5% | 276,881 | 0% | $2,037,844 | |
| Boxer Capital Management, LLC | 1.3% | 252,536 | 0.41% | $1,858,665 | |
| BlackRock, Inc. | 1.3% | 247,558 | +6.7% | 0% | $1,822,026 |
| GEODE CAPITAL MANAGEMENT, LLC | 0.99% | 187,734 | +101% | 0% | $1,381,872 |
| TWO SIGMA INVESTMENTS, LP | 0.78% | 148,793 | 0% | $1,095,116 | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.78% | 147,698 | +318% | 0% | $1,087,057 |
| BOOTHBAY FUND MANAGEMENT, LLC | 0.76% | 144,628 | 0.03% | $1,064,462 | |
| Catalio Capital Management, LP | 0.75% | 142,984 | 0% | 0.2% | $1,052,362 |
| Avidity Partners Management LP | 0.71% | 134,566 | 0% | 0.29% | $990,406 |
| MARSHALL WACE, LLP | 0.68% | 128,451 | 0% | 0% | $945,400 |
| GROUP ONE TRADING LLC | 0.54% | 102,419 | +50% | 0.02% | $753,804 |
| C WorldWide Group Holding A/S | 0.53% | 100,000 | 0% | 0.01% | $736,000 |
| Walleye Capital LLC | 0.5% | 95,672 | 0% | $704,146 | |
| TWO SIGMA ADVISERS, LP | 0.47% | 89,729 | 0% | $660,405 | |
| UBS Group AG | 0.47% | 88,455 | +48% | 0% | $651,029 |
Institutional Holders of Karyopharm Therapeutics Inc. - COMMON STOCK (KPTI) across Reporting Periods
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q1 | 247,382 | $1,379,525 | +$819,538 | $5.57 | 9 |
| 2025 Q4 | 9,456,135 | $69,598,197 | +$47,945,529 | $7.36 | 68 |
| 2025 Q3 | 2,947,949 | $19,279,960 | -$7,678,877 | $6.54 | 51 |
| 2025 Q2 | 4,384,748 | $18,898,424 | +$4,718,131 | $4.31 | 49 |
| 2025 Q1 | 3,312,099 | $12,386,156 | +$12,277,831 | $3.74 | 47 |