Security key
48576U205
Karyopharm Therapeutics Inc. - Common Stock, $0.0001 par value (KPTI)
CUSIP: 48576U205
Q4 2025 13F Holders as of 31 Dec 2025
- Security type / class
- Equity / Common Stock, $0.0001 par value
- Total 13F shares
- 9,456,135
- Total 13F value
- $69,598,197
- Share change
- +6,508,186
- Put/Call ratio
- 102%
- SEC-reported price per share
- $7.36
- Number of holders
- 68
- Value change
- +$47,945,529
- Number of buys
- 45
- Number of sells
- 14
- Shares outstanding
- 23,257,616
Holder snapshot
7 signals
Open additional details 1 more signal available
Security identity
Names, identifiers, and filing context for this profile.
1 source field
Report period
Q4 2025
Institutions
68
Top holders
10
KPTI full security history
Ownership snapshot
Full 13F holder table
Karyopharm Therapeutics Inc. SEC filings
Karyopharm Therapeutics Inc. company facts
Broader feeds
Ownership snapshot
Top reported holders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, $0.0001 par value (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
Opaleye Management Inc.
Disclosed value leader
Opaleye Management Inc.
Comparable rows
15/15
Latest evidence
14 Oct 2025
13D/G
13F
Lead comparable stake: 9.5%
13D/G row: Opaleye Management Inc.
Showing 1-6 of 15 holder rows.
Quick read
Opaleye Management Inc. leads the comparable SEC ownership view at 9.5%.
15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens Opaleye Management Inc.'s linked filing trail.
Comparable ownership
Top 5
Opaleye Management Inc.
9.5%
J. WOOD CAPITAL ADVISORS LLC
5%
HIGHBRIDGE CAPITAL MANAGEMENT LLC
4.9%
JPMORGAN CHASE & CO
4.9%
VANGUARD GROUP INC
4.7%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-6 of 15 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| Opaleye Management Inc. |
13D/G
|
9.5%
|
$10,262,842
1,569,002 shares
|
$0 | 10 Oct 2025 |
| J. WOOD CAPITAL ADVISORS LLC |
13D/G
|
5%
|
$6,546,231
1,000,708 shares
|
$0 | 14 Oct 2025 |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC |
13D/G
|
4.9%
|
$4,250,895
649,984 shares
|
$0 | 30 Sep 2025 |
| JPMORGAN CHASE & CO |
13D/G
13F
Company
|
4.9%
|
$2,797,089
427,624 shares
|
-$149,213 | 30 Sep 2025 |
| VANGUARD GROUP INC |
13D/G
13F
The Vanguard Group · Company
|
4.7%
|
$2,670,221
408,222 shares
|
$0 | 30 Sep 2025 |
| T. Rowe Price Investment Management, Inc. |
13F
Company
|
3%
|
$4,585,000
700,992 shares
|
— | 30 Sep 2025 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
13F holder rows
Institutional holders as of Q4 2025
Investor-level positions for this CUSIP, loaded as an interactive table.
Institutions
68
Shares
9,456,135
Rows available
68
| Investor | Option | Weight % | Change % | SEC-reported value | * Price | Shares | Share Change | Activity | Report Period |
|---|
* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
51
Q4 2025 holders
68
Holder diff
17
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 value | Q4 2025 value | Value change | Value Chg % |
|---|