Opaleye Management Inc. - 10 Oct 2025 SCHEDULE 13G Report for Karyopharm Therapeutics Inc. Common Stock, no par value (KPTI)

Filing Manager
Opaleye Management Inc.
Reporting Manager
Opaleye Management Inc.
Security
Karyopharm Therapeutics Inc. Common Stock, no par value
Symbol
KPTI
Shares outstanding
16,550,654 shares
Disclosed Ownership
1,569,002 shares
Ownership
9.48%
Form type
SCHEDULE 13G
Filing time
17 Oct 2025, 16:05:17 UTC
Date of event
10 Oct 2025
SEC
View on sec.gov

Reporting Managers (3)

Name Ownership Shares Owned sole voting power shared voting power Signature Title CIK
Opaleye Management Inc. 9.48% 1,569,002 0 1,569,002 /s/ James Silverman President
Opaleye, L.P. 9.48% 1,569,002 0 1,569,002 /s/ James Silverman General Partner
James Silverman 9.48% 1,569,002 0 1,569,002 /s/ James Silverman Individually