Opaleye Management Inc.

Holdings History for Karyopharm Therapeutics Inc. - COMMON STOCK (KPTI)

Symbol: KPTI on Nasdaq
Investment type: Equity / COMMON STOCK
Latest Disclosed Shares Owned: 1,569,002 shares
Security Ownership %: 9.5%

Shares, Excluding Options vs Price

Value, Excluding Options

Opaleye Management Inc. ownership in Karyopharm Therapeutics Inc. COMMON STOCK (KPTI)

17 Oct 2025 - Opaleye Management Inc. has filed an SCHEDULE 13G form with the Securities and Exchange Commission (SEC) disclosing ownership of 1,569,002 shares of Karyopharm Therapeutics Inc. COMMON STOCK (KPTI). This represents 9.5% ownership of the company. This is the first filing by Opaleye Management Inc. disclosing ownership of Karyopharm Therapeutics Inc. COMMON STOCK (KPTI).

Reporting Name	Ownership %	Change	Value $	Shares owned	Change	Activity %	Price	Form	Report date	Filing time
Opaleye Management Inc.	9.5%		$10,262,842	1,569,002			$6.54	13G	10 Oct 2025	17 Oct 2025, 16:05

Holdings date	Option	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025		0.91%	+0.91%	$6,844,800	930,000	+930,000	NEW	$7.36	Q4 2025

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.