Security key
462222100
IONIS PHARMACEUTICALS INC - COMMON STOCK (IONS)
CUSIP: 462222100
Q4 2025 13F Holders as of 31 Dec 2025
- Security type / class
- Equity / COMMON STOCK
- Total 13F shares
- 170,226,720
- Total 13F value
- $13,463,922,363
- Share change
- +1,474,732
- Put/Call ratio
- 67%
- SEC-reported price per share
- $79.11
- Number of holders
- 491
- Value change
- +$164,534,797
- Number of buys
- 260
- Number of sells
- 184
- Shares outstanding
- 166,460,189
Holder snapshot
7 signals
Open additional details 1 more signal available
Security identity
Names, identifiers, and filing context for this profile.
1 source field
Report period
Q4 2025
Institutions
491
Top holders
10
IONS full security history
Ownership snapshot
Full 13F holder table
Newer quarter: Q3 2026
IONIS PHARMACEUTICALS INC SEC filings
IONIS PHARMACEUTICALS INC company facts
Broader feeds
Reporting periods
Holder history for CUSIP 462222100
Recent filing periods:
Ownership snapshot
Top reported holders of IONS - IONIS PHARMACEUTICALS INC - COMMON STOCK (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
BlackRock, Inc.
Disclosed value leader
FMR LLC
Comparable rows
2/15
Latest evidence
30 Sep 2025
13F
13D/G
Lead comparable stake: 5.7%
13 rows are not safely comparable across share classes.
13D/G row: BlackRock, Inc.
Showing 1-6 of 15 holder rows.
Quick read
BlackRock, Inc. leads the comparable SEC ownership view at 5.7%.
2 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens BlackRock, Inc.'s linked filing trail.
Comparable ownership
Top 2
BlackRock, Inc.
5.7%
WELLINGTON MANAGEMENT GROUP LLP
4.3%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-6 of 15 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| BlackRock, Inc. |
13F
13D/G
Company
|
5.7%
Reported 13D/G
· 31 Mar 2025
|
$683,504,235
10,447,940 shares
|
— | 30 Sep 2025 |
| WELLINGTON MANAGEMENT GROUP LLP |
13F
13D/G
Company
|
4.3%
Reported 13D/G
· 30 Jun 2025
|
$431,040,015
6,588,811 shares
|
— | 30 Sep 2025 |
| FMR LLC |
13F
Company
|
—
denominator unverified
|
$1,549,736,866
23,689,038 shares
|
— | 30 Sep 2025 |
| VANGUARD GROUP INC |
13F
Company
|
—
denominator unverified
|
$1,078,234,776
16,481,730 shares
|
— | 30 Sep 2025 |
| T. Rowe Price Investment Management, Inc. |
13F
Company
|
—
denominator unverified
|
$860,727,000
13,156,929 shares
|
— | 30 Sep 2025 |
| Capital World Investors |
13F
Company
|
—
denominator unverified
|
$832,320,866
12,722,728 shares
|
— | 30 Sep 2025 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
13F holder rows
Institutional holders as of Q4 2025
Investor-level positions for this CUSIP, loaded as an interactive table.
Institutions
491
Shares
170,226,720
Rows available
491
| Investor | Option | Weight % | Change % | SEC-reported value | * Price | Shares | Share Change | Activity | Report Period |
|---|
* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
433
Q4 2025 holders
491
Holder diff
58
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 value | Q4 2025 value | Value change | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend