Filer Snapshot

Opaleye Management Inc.

CIK 0001595855. SEC filing timeline plus parsed ownership intelligence from 13F, 13D/G, and Forms 3/4/5 where available.

Entity type

Company

Total filings

109

Latest filing

14 Aug 2026

Industry

n/a

Filing-backed research brief

Start with the SEC data that changes for this CIK

Latest signal: 13F-HR for Q2 2026. Each card links back to the PortfolioSavvy page where the filing evidence is closest.

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Largest parsed holding

LQDA

$195.14M reported value

Open holding

13D/G large stake

GRCE

05 Aug 2026 · 13% ownership

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Source: SEC Forms 3/4/5

4 filed on 14 Aug 2026 for CIK 0001595855.

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Ownership signals CIK-linked ownership evidence from parsed SEC filings. 1 signal
Parsed SEC ownership signals

Parsed SEC ownership coverage

These bars compare filing-backed value available in each disclosure family. Read them as separate lenses, not as one combined ownership total.

13F portfolio$1.1B

Quarterly institutional holdings reported on Form 13F; not total AUM.

Forms 3/4/5 positions$363.1M

Reporting-owner positions with enough filing detail to estimate value.

Latest reported 13F value

13F
$1.1B

Reported market value from the latest parsed Form 13F information table; this is not total assets under management.

Source: SEC Form 13FScope: U.S.-listed equity holdings

Forms 3/4/5 position value

3/4/5
$363.1M

Estimated from parsed Forms 3/4/5 when filings include enough share and price data.

Source: Forms 3/4/5Confidence: Estimated when price data is available

Largest 13F holdings

13F
LQDA ETON HROW IRON URGN
+15 moreAPGE MGTX SLGL RZLT TGTX IMMX CBIO STOK ACOG EWTX RVMD GLUE ALMS CDXS REPL

Largest symbols in the latest parsed Form 13F information table.

Freshness: Latest parsed 13F period

Largest linked holdings

Largest issuer positions linked to this CIK across parsed 13F, 13D/G, and Forms 3/4/5 records.

HROW ETON SLGL ACOG CDXS SNWV TELA GRCE
+1 moreTARA

Largest 13F holdings

Largest symbols in the latest parsed Form 13F information table.

LQDA ETON HROW IRON URGN APGE MGTX SLGL
+12 moreRZLT TGTX IMMX CBIO STOK ACOG EWTX RVMD GLUE ALMS CDXS REPL

Largest active 13G stakes

Passive or institutional large-stake positions disclosed in parsed Schedule 13G filings.

HROW RZLT SLGL OCUL ACOG QTTB
+10 moreCDXS LRMR SNWV KPTI TARA GRCE GOSS KTTA IBIO CNTX
How to read these SEC ownership signals
  • Read each filing family separately: Form 13F, Schedules 13D/G, and Forms 3/4/5 answer different SEC disclosure questions and should not be blended into one ownership total.
  • Use 13F values for visible U.S.-listed equity portfolios, 13D/G rows for large beneficial-owner stakes, and Forms 3/4/5 rows for reporting-owner positions and transactions.
  • Open the linked research path when you need the filing, CIK, issuer, CUSIP, date, or source trail behind a value.
At a glance Names, identifiers, and filing context for this profile. 1 identity field
Business address
One Boston Place, Suite 2600, Boston, MA, 02108
EDGAR profile Static EDGAR fields kept behind disclosure so the main profile stays readable. 2 profile fields available
Incorporated in
MA
Fiscal year end
31 December

Filer intelligence

What SEC filings say about Opaleye Management Inc.

A compact read of parsed XML filings. 13F, 13D/G, and Forms 3/4/5 are shown separately because they answer different ownership questions.

Open 13F portfolio Save filer

Quick read

  • Latest parsed 13F shows $1.1B across 58 reported holdings for Q2 2026.
  • Largest parsed 13F holding: LQDA at $195.14M.
  • 5 recent 13D/G stake rows found; top row is GRCE at 13% ownership.
  • Forms 3/4/5 show insider context for HROW worth $146.05M.

SEC source mix

Counts show available parsed rows, not one combined ownership total.

XML parsed
13F portfolio 58 rows

Quarterly institutional portfolio holdings.

Open
13D/G stakes 5 rows

Beneficial ownership and large-stake disclosures.

Open
Forms 3/4/5 5 rows

Officer, director, and 10% owner holdings or transactions.

Open

Top parsed 13F holdings

Visual share of the latest parsed 13F portfolio. Values are reported market value, not a recommendation.

Q2 2026 - 14 Aug 2026

Top 5 concentration

47%

Share of latest parsed 13F value represented by the visible holdings below.

Top 5 reported value

$516.13M

Compared with $1.1B total 13F value.

Top 5 net change

+$5.98M

Position-value change inside the visible top holdings only.

13F concentration map

A simple visual split of the latest parsed 13F portfolio.

Largest add: IRON · Largest trim: CATX

LQDA ETON HROW IRON URGN Other holdings

LQDA

17.7%

Liquidia Corporation

$195.14M

ETON

9.4%

Eton Pharmaceuticals Inc

$103.53M

HROW

9.2%

Harrow Inc

$101.93M

IRON

5.7%

Disc Medicine Inc

$62.53M

URGN

4.8%

Urogen Pharma Ltd

$52.99M

13D/G large-stake context

GRCE

05 Aug 2026 · Common Stock, par value $0.0001 per share

13%
Issuer page 13D/G history

ACOG

23 Jul 2026 · Common Stock, no par value

14%
Issuer page 13D/G history

GOSS

22 Jul 2026 · Common Stock, par value $0.0001 per share

5.1%
Issuer page 13D/G history

HROW

30 Jun 2026 · Common Stock, $0.001 par value per share

6.4%
Issuer page 13D/G history

Forms 3/4/5 insider context

HROW

03 Mar 2026 · 10% owner

$146.05M
Issuer page Owner page

ETON

14 Jul 2026 · 10% owner

$102.9M
Issuer page Owner page

SLGL

01 Sep 2026 · 10% owner

$37.44M
Issuer page Owner page

ACOG

31 Jul 2026 · 10% owner

$25.11M
Issuer page Owner page

Latest update

What changed recently for Opaleye Management Inc.

Ownership report updated

Latest ownership report period: 01 Sep 2026. Open the source-backed page to inspect the fresh filing or facts context.

Update date

03 Sep 2026

Page type

Ownership filings

Latest period

01 Sep 2026

Ownership context was refreshed from SEC Forms 3/4/5 filed on 03 Sep 2026.

Open ownership filings Browse recent public updates

Benchmark Context

Benchmark context for this company

Opaleye Management Inc. has a source-backed company facts view where you can compare the latest reported metrics with its own recent history and with peer rankings for the same metric.

Compared with

Start on the facts page for period-to-period context, then open a metric ranking when you want to compare the same reported fact across other SEC-reporting companies.

Why this is notable

Latest ownership report period: 01 Sep 2026. That gives you a fresh baseline before you compare this company with peers.

  • Peer comparisons stay conservative: same metric, compatible units, latest valid company row only.
  • Open the facts page first if you want the cleanest path to verification.

Benchmark context is only shown where the app has enough comparable SEC-backed data to keep the interpretation honest.

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SEC filing record

CIK 0001595855 filing coverage

Start with this filing record, then use the linked ownership pages when parsed 13F, 13D/G, Forms 3/4/5, or facts data exists for this CIK.

SEC filings
109
First seen
14 Feb 2014
Latest filing
14 Aug 2026
Entity
Company

Observed form types

13F-HR 13F-HR/A 4 4/A SCHEDULE 13G SCHEDULE 13G/A

CIK-linked evidence first

Opaleye Management Inc. SEC filings Opaleye Management Inc. 13F portfolio Opaleye Management Inc. 13D/G history Opaleye Management Inc. owner filings Open SEC filing index

Latest Filings

Showing the latest 12 of 109 SEC filings for Opaleye Management Inc..

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4

4 filing

Filing date
14 Aug 2026
Reporting date
12 Aug 2026
SEC evidence
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13F-HR

13F-HR filing

Filing date
14 Aug 2026
Reporting date
30 Jun 2026
SEC evidence
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SCHEDULE 13G

SCHEDULE 13G filing

Filing date
07 Aug 2026
Reporting date
Not listed
SEC evidence
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SCHEDULE 13G/A

SCHEDULE 13G/A filing

Filing date
31 Jul 2026
Reporting date
Not listed
SEC evidence
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SCHEDULE 13G/A

SCHEDULE 13G/A filing

Filing date
31 Jul 2026
Reporting date
Not listed
SEC evidence
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SCHEDULE 13G/A

SCHEDULE 13G/A filing

Filing date
31 Jul 2026
Reporting date
Not listed
SEC evidence
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SCHEDULE 13G/A

SCHEDULE 13G/A filing

Filing date
31 Jul 2026
Reporting date
Not listed
SEC evidence
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SCHEDULE 13G

SCHEDULE 13G filing

Filing date
29 Jul 2026
Reporting date
Not listed
SEC evidence
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SCHEDULE 13G/A

SCHEDULE 13G/A filing

Filing date
24 Jul 2026
Reporting date
Not listed
SEC evidence
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SCHEDULE 13G/A

SCHEDULE 13G/A filing

Filing date
29 Jun 2026
Reporting date
Not listed
SEC evidence
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SCHEDULE 13G/A

SCHEDULE 13G/A filing

Filing date
22 May 2026
Reporting date
Not listed
SEC evidence
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13F-HR

13F-HR filing

Filing date
15 May 2026
Reporting date
31 Mar 2026
SEC evidence
Open document Open filing
Next action
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