Opaleye Management Inc.

Business address
One Boston Place, Suite 2600, Boston, MA, 02108
Top holdings (ownership)
HROW, ETON, SNWV, SLGL, CDXS, TELA, and TARA
Top securities (13F)
HROW, ETON, LQDA, RYTM, IMNM, SNWV, CDXS, TGTX, OCUL, CGON, STOK, APGE, ALKS, IRON, SRPT, LRMR, XOMA, RZLT, ARVN, and EWTX
State of incorporation
MA
Fiscal year end
31 December
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Opaleye Management Inc. has filed 368 SEC EDGAR filings since 16 Jan 2014

Latest Filings

Form type Document Filing Description Filing date Reporting date File number(s)
4 Open Document Open Filing 4 06 Jan 2026 02 Jan 2026 001-38367
4 Open Document Open Filing 31 Dec 2025 29 Dec 2025 001-38367
4 Open Document Open Filing 4 29 Dec 2025 22 Dec 2025 001-38367
4 Open Document Open Filing 4 19 Dec 2025 17 Dec 2025 001-38367
SCHEDULE 13G Open Document Open Filing 19 Dec 2025
4 Open Document Open Filing 4 16 Dec 2025 12 Dec 2025 001-38367
4/A Open Document Open Filing 15 Dec 2025 26 Nov 2025 001-34705
4/A Open Document Open Filing 15 Dec 2025 07 Nov 2025 001-34705
4 Open Document Open Filing 4 09 Dec 2025 05 Dec 2025 001-38367
SCHEDULE 13G/A Open Document Open Filing 05 Dec 2025
4 Open Document Open Filing 4 03 Dec 2025 01 Dec 2025 001-38367
4 Open Document Open Filing 4 01 Dec 2025 26 Nov 2025 001-34705
4 Open Document Open Filing 4 26 Nov 2025 24 Nov 2025 001-38367
4 Open Document Open Filing 21 Nov 2025 20 Nov 2025 001-38367
3 Open Document Open Filing 3 17 Nov 2025 13 Nov 2025 001-38367
SCHEDULE 13G/A Open Document Open Filing 17 Nov 2025
4 Open Document Open Filing 4 14 Nov 2025 12 Nov 2025 001-34705
SCHEDULE 13G/A Open Document Open Filing 14 Nov 2025
13F-HR Open Document Open Filing 14 Nov 2025 30 Sep 2025 028-15896
4 Open Document Open Filing 12 Nov 2025 07 Nov 2025 001-34705
N-PX Open Document Open Filing 27 Oct 2025 30 Jun 2025 028-15896
SCHEDULE 13G Open Document Open Filing 17 Oct 2025
4 Open Document Open Filing 4 09 Oct 2025 06 Oct 2025 001-42552
SCHEDULE 13G Open Document Open Filing 03 Oct 2025
SCHEDULE 13G Open Document Open Filing 29 Aug 2025
SCHEDULE 13G Open Document Open Filing 29 Aug 2025
13F-HR/A Open Document Open Filing 15 Aug 2025 30 Jun 2025 028-15896
13F-HR Open Document Open Filing 14 Aug 2025 30 Jun 2025 028-15896
4 Open Document Open Filing 4 04 Aug 2025 31 Jul 2025 001-34705
4 Open Document Open Filing 31 Jul 2025 29 Jul 2025 001-34705
4 Open Document Open Filing 22 Jul 2025 18 Jul 2025 001-34705
4 Open Document Open Filing 01 Jul 2025 27 Jun 2025 001-34705
4 Open Document Open Filing 16 Jun 2025 12 Jun 2025 001-34705
4 Open Document Open Filing 12 Jun 2025 10 Jun 2025 001-38738
4 Open Document Open Filing 11 Jun 2025 09 Jun 2025 001-35814
4 Open Document Open Filing 05 Jun 2025 03 Jun 2025 001-35814
4 Open Document Open Filing 28 May 2025 23 May 2025 001-34705
13F-HR Open Document Open Filing 15 May 2025 31 Mar 2025 028-15896
4 Open Document Open Filing 14 May 2025 12 May 2025 001-35814
4/A Open Document Open Filing 14 May 2025 18 Mar 2025 001-35814
4/A Open Document Open Filing 14 May 2025 24 Mar 2025 001-35814
4 Open Document Open Filing 02 May 2025 30 Apr 2025 001-34705
4 Open Document Open Filing 30 Apr 2025 29 Apr 2025 001-42552
4 Open Document Open Filing 29 Apr 2025 25 Apr 2025 001-34705
SCHEDULE 13G/A Open Document Open Filing 28 Apr 2025
4 Open Document Open Filing 17 Apr 2025 15 Apr 2025 001-34705
SCHEDULE 13G Open Document Open Filing 16 Apr 2025
4 Open Document Open Filing 09 Apr 2025 08 Apr 2025 001-34705
4 Open Document Open Filing 03 Apr 2025 01 Apr 2025 001-34705
4 Open Document Open Filing 26 Mar 2025 24 Mar 2025 001-35814
4 Open Document Open Filing 24 Mar 2025 20 Mar 2025 001-34705
4 Open Document Open Filing 20 Mar 2025 18 Mar 2025 001-35814
4 Open Document Open Filing 14 Mar 2025 13 Mar 2025 001-34705
4 Open Document Open Filing 10 Mar 2025 06 Mar 2025 001-34705
4 Open Document Open Filing 06 Mar 2025 04 Mar 2025 001-34705
4 Open Document Open Filing 04 Mar 2025 28 Feb 2025 001-35814
4 Open Document Open Filing 04 Mar 2025 28 Feb 2025 001-34705
13F-HR Open Document Open Filing 14 Feb 2025 31 Dec 2024 028-15896
SCHEDULE 13G/A Open Document Open Filing 14 Feb 2025
SCHEDULE 13G/A Open Document Open Filing 14 Feb 2025
SCHEDULE 13G/A Open Document Open Filing 14 Feb 2025
SCHEDULE 13G/A Open Document Open Filing 14 Feb 2025
4 Open Document Open Filing 12 Feb 2025 10 Feb 2025 001-34705
4 Open Document Open Filing 31 Jan 2025 30 Jan 2025 001-34705
4 Open Document Open Filing 24 Jan 2025 22 Jan 2025 001-35814
4 Open Document Open Filing 02 Jan 2025 30 Dec 2024 001-34705
SC 13G Open Document Open Filing 18 Nov 2024
13F-HR Open Document Open Filing 14 Nov 2024 30 Sep 2024 028-15896
4 Open Document Open Filing 01 Nov 2024 30 Oct 2024 000-52985
4 Open Document Open Filing 28 Oct 2024 25 Oct 2024 001-34705
4 Open Document Open Filing 25 Oct 2024 23 Oct 2024 001-38738
SC 13G/A Open Document Open Filing 22 Oct 2024
4 Open Document Open Filing 08 Oct 2024 04 Oct 2024 001-38738
4 Open Document Open Filing 26 Sep 2024 24 Sep 2024 001-34705
4 Open Document Open Filing 23 Sep 2024 20 Sep 2024 001-34705
4 Open Document Open Filing 19 Sep 2024 18 Sep 2024 001-34705
SC 13G/A Open Document Open Filing 18 Sep 2024
4 Open Document Open Filing 12 Sep 2024 11 Sep 2024 001-36694
4 Open Document Open Filing 12 Sep 2024 10 Sep 2024 001-38738
SC 13G/A Open Document Open Filing 12 Sep 2024
3 Open Document Open Filing 12 Sep 2024 09 Sep 2024 001-38738
4 Open Document Open Filing 10 Sep 2024 09 Sep 2024 001-36694
N-PX Open Document Open Filing 03 Sep 2024 30 Jun 2024 028-15896
13F-HR Open Document Open Filing 14 Aug 2024 30 Jun 2024 028-15896
4 Open Document Open Filing 18 Jul 2024 16 Jul 2024 001-36694
SC 13G Open Document Open Filing 12 Jul 2024
4 Open Document Open Filing 11 Jul 2024 09 Jul 2024 001-36694
4 Open Document Open Filing 03 Jul 2024 01 Jul 2024 001-36694
4 Open Document Open Filing 28 Jun 2024 27 Jun 2024 001-36694
4 Open Document Open Filing 27 Jun 2024 25 Jun 2024 001-36694
4 Open Document Open Filing 31 May 2024 30 May 2024 001-36694
13F-HR/A Open Document Open Filing 29 May 2024 31 Mar 2024 028-15896
4 Open Document Open Filing 23 May 2024 21 May 2024 001-36694
4 Open Document Open Filing 17 May 2024 17 May 2024 001-36694
13F-HR Open Document Open Filing 15 May 2024 31 Mar 2024 028-15896
4 Open Document Open Filing 10 May 2024 09 May 2024 001-36694
4 Open Document Open Filing 25 Apr 2024 25 Apr 2024 001-35814
4 Open Document Open Filing 24 Apr 2024 23 Apr 2024 001-35814
4 Open Document Open Filing 19 Apr 2024 19 Apr 2024 001-35814
SC 13G/A Open Document Open Filing 09 Apr 2024
SC 13G Open Document Open Filing 08 Apr 2024
4 Open Document Open Filing 28 Mar 2024 28 Mar 2024 001-35814
4 Open Document Open Filing 22 Mar 2024 20 Mar 2024 001-35814
SC 13G/A Open Document Open Filing 14 Feb 2024
13F-HR Open Document Open Filing 14 Feb 2024 31 Dec 2023 028-15896
SC 13G/A Open Document Open Filing 14 Feb 2024
SC 13G Open Document Open Filing 09 Feb 2024
SC 13G/A Open Document Open Filing 09 Feb 2024
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SC 13G Open Document Open Filing 05 Jan 2024
4 Open Document Open Filing 16 Nov 2023 19 Sep 2023 001-35814
13F-HR Open Document Open Filing 15 Nov 2023 30 Sep 2023 028-15896
4 Open Document Open Filing 14 Nov 2023 10 Nov 2023 001-36818
4 Open Document Open Filing 20 Sep 2023 19 Sep 2023 001-35814
13F-HR Open Document Open Filing 14 Aug 2023 30 Jun 2023 028-15896
13F-HR Open Document Open Filing 15 May 2023 31 Mar 2023 028-15896
4 Open Document Open Filing 20 Apr 2023 20 Apr 2023 001-39130
SC 13G Open Document Open Filing 12 Apr 2023
4 Open Document Open Filing 13 Mar 2023 09 Mar 2023 001-36818
SC 13G/A Open Document Open Filing 13 Feb 2023
SC 13G/A Open Document Open Filing 13 Feb 2023
SC 13G/A Open Document Open Filing 13 Feb 2023
13F-HR Open Document Open Filing 10 Feb 2023 31 Dec 2022 028-15896
SC 13G/A Open Document Open Filing 23 Jan 2023
SC 13G/A Open Document Open Filing 20 Jan 2023
SC 13G/A Open Document Open Filing 20 Jan 2023
4 Open Document Open Filing 30 Dec 2022 30 Dec 2022 001-36694
4 Open Document Open Filing 16 Dec 2022 14 Dec 2022 001-36818
4 Open Document Open Filing 14 Dec 2022 14 Dec 2022 001-35814
4 Open Document Open Filing 08 Dec 2022 06 Dec 2022 001-36818
13F-HR Open Document Open Filing 14 Nov 2022 30 Sep 2022 028-15896
4 Open Document Open Filing 04 Nov 2022 03 Nov 2022 001-39130
4 Open Document Open Filing 19 Oct 2022 18 Oct 2022 001-36818
4 Open Document Open Filing 11 Oct 2022 11 Oct 2022 001-39130
4 Open Document Open Filing 03 Oct 2022 29 Sep 2022 001-36818
4 Open Document Open Filing 30 Sep 2022 28 Sep 2022 001-35814
4 Open Document Open Filing 28 Sep 2022 27 Sep 2022 001-36818
4 Open Document Open Filing 26 Sep 2022 23 Sep 2022 001-39130
4 Open Document Open Filing 22 Sep 2022 22 Sep 2022 001-36818
4 Open Document Open Filing 20 Sep 2022 20 Sep 2022 001-36818
4 Open Document Open Filing 19 Sep 2022 19 Sep 2022 001-39130
4 Open Document Open Filing 19 Sep 2022 19 Sep 2022 001-36818
4 Open Document Open Filing 16 Sep 2022 15 Sep 2022 001-39130
4 Open Document Open Filing 15 Sep 2022 13 Sep 2022 001-39130
4 Open Document Open Filing 15 Sep 2022 14 Sep 2022 001-36694
4 Open Document Open Filing 16 Aug 2022 16 Aug 2022 001-39130
13F-HR Open Document Open Filing 15 Aug 2022 30 Jun 2022 028-15896
4/A Open Document Open Filing 12 Aug 2022 01 Aug 2022 001-39130
4 Open Document Open Filing 12 Aug 2022 10 Aug 2022 001-39130
4 Open Document Open Filing 02 Aug 2022 01 Aug 2022 001-39130
4 Open Document Open Filing 26 Jul 2022 26 Jul 2022 001-36818
4 Open Document Open Filing 22 Jul 2022 22 Jul 2022 001-39130
4 Open Document Open Filing 21 Jul 2022 21 Jul 2022 001-39130
4 Open Document Open Filing 20 Jul 2022 20 Jul 2022 001-39130
4 Open Document Open Filing 15 Jul 2022 15 Jul 2022 001-36818
4 Open Document Open Filing 14 Jul 2022 14 Jul 2022 001-36818
4 Open Document Open Filing 05 Jul 2022 01 Jul 2022 001-39130
4 Open Document Open Filing 30 Jun 2022 29 Jun 2022 001-39130
4 Open Document Open Filing 27 Jun 2022 24 Jun 2022 001-36818
4 Open Document Open Filing 24 Jun 2022 24 Jun 2022 001-39130
4 Open Document Open Filing 23 Jun 2022 21 Jun 2022 001-36818
4 Open Document Open Filing 22 Jun 2022 22 Jun 2022 001-39130
4 Open Document Open Filing 10 Jun 2022 10 Jun 2022 001-39130
SC 13D Open Document Open Filing 10 Jun 2022
SC 13G Open Document Open Filing 03 Jun 2022
13F-HR Open Document Open Filing 16 May 2022 31 Mar 2022 028-15896
4 Open Document Open Filing 10 May 2022 10 May 2022 001-36818
4 Open Document Open Filing 29 Apr 2022 29 Apr 2022 001-36818
4 Open Document Open Filing 25 Apr 2022 22 Apr 2022 001-36818
4/A Open Document Open Filing 15 Apr 2022 07 Apr 2022 001-36694
4 Open Document Open Filing 14 Apr 2022 13 Apr 2022 001-36818
4 Open Document Open Filing 13 Apr 2022 12 Apr 2022 001-35814
4 Open Document Open Filing 12 Apr 2022 11 Apr 2022 001-36818
4 Open Document Open Filing 08 Apr 2022 07 Apr 2022 001-36694
4 Open Document Open Filing 17 Mar 2022 16 Mar 2022 001-36818
SC 13G Open Document Open Filing 18 Feb 2022
13F-HR Open Document Open Filing 14 Feb 2022 31 Dec 2021 028-15896
SC 13G/A Open Document Open Filing 01 Feb 2022
SC 13G/A Open Document Open Filing 01 Feb 2022
SC 13G/A Open Document Open Filing 01 Feb 2022
4 Open Document Open Filing 31 Jan 2022 28 Jan 2022 001-36694
4 Open Document Open Filing 31 Jan 2022 28 Jan 2022 001-36818
4 Open Document Open Filing 31 Jan 2022 28 Jan 2022 001-35814
SC 13G/A Open Document Open Filing 26 Jan 2022
SC 13G/A Open Document Open Filing 26 Jan 2022
SC 13G/A Open Document Open Filing 26 Jan 2022
4 Open Document Open Filing 24 Jan 2022 21 Jan 2022 001-36818
SC 13G/A Open Document Open Filing 24 Jan 2022
4 Open Document Open Filing 21 Jan 2022 19 Jan 2022 001-36818
4 Open Document Open Filing 29 Dec 2021 28 Dec 2021 001-36694
4 Open Document Open Filing 29 Dec 2021 29 Dec 2021 001-36818
4 Open Document Open Filing 29 Dec 2021 27 Dec 2021 001-36818
4 Open Document Open Filing 27 Dec 2021 23 Dec 2021 001-36694
4 Open Document Open Filing 22 Dec 2021 20 Dec 2021 001-36694
4 Open Document Open Filing 20 Dec 2021 16 Dec 2021 001-36694
4 Open Document Open Filing 16 Dec 2021 01 Dec 2021 001-36818
4 Open Document Open Filing 15 Dec 2021 01 Dec 2021 001-36818
4 Open Document Open Filing 07 Dec 2021 01 Dec 2021 001-36818
4 Open Document Open Filing 03 Dec 2021 01 Dec 2021 001-36818
4 Open Document Open Filing 19 Nov 2021 17 Nov 2021 001-36694
4 Open Document Open Filing 19 Nov 2021 17 Nov 2021 001-38738
4 Open Document Open Filing 17 Nov 2021 15 Nov 2021 001-38738
13F-HR Open Document Open Filing 16 Nov 2021 30 Sep 2021 028-15896
4 Open Document Open Filing 09 Nov 2021 05 Nov 2021 001-38738
4 Open Document Open Filing 08 Nov 2021 04 Nov 2021 001-36694
4 Open Document Open Filing 05 Nov 2021 03 Nov 2021 001-38738
4 Open Document Open Filing 13 Oct 2021 08 Oct 2021 001-38738
4 Open Document Open Filing 23 Aug 2021 19 Aug 2021 001-35814
4 Open Document Open Filing 19 Aug 2021 17 Aug 2021 001-35814
13F-HR Open Document Open Filing 16 Aug 2021 30 Jun 2021 028-15896
4 Open Document Open Filing 06 Aug 2021 04 Aug 2021 001-38738
4 Open Document Open Filing 22 Jul 2021 19 Jul 2021 001-35814
4 Open Document Open Filing 22 Jun 2021 17 Jun 2021 001-35814
4/A Open Document Open Filing 21 Jun 2021 15 Jun 2021 001-38738
SC 13G/A Open Document Open Filing 17 Jun 2021
4 Open Document Open Filing 17 Jun 2021 26 May 2021 001-38738
4 Open Document Open Filing 27 May 2021 25 May 2021 001-38738
13F-HR Open Document Open Filing 18 May 2021 31 Mar 2021 028-15896
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13F-HR Open Document Open Filing 12 Feb 2021 31 Dec 2020 028-15896
SC 13G Open Document Open Filing 08 Jan 2021
4 Open Document Open Filing 28 Dec 2020 22 Dec 2020 001-36818
4 Open Document Open Filing 22 Dec 2020 18 Dec 2020 001-35814
13F-HR Open Document Open Filing 16 Nov 2020 30 Sep 2020 028-15896
4 Open Document Open Filing 23 Oct 2020 21 Oct 2020 001-36818
4 Open Document Open Filing 16 Oct 2020 16 Oct 2020 001-38738
4 Open Document Open Filing 02 Oct 2020 30 Sep 2020 001-36694
4 Open Document Open Filing 25 Sep 2020 23 Sep 2020 001-36818
SC 13D/A Open Document Open Filing 25 Sep 2020
4 Open Document Open Filing 25 Sep 2020 24 Sep 2020 001-36694
SC 13G Open Document Open Filing 21 Sep 2020
4 Open Document Open Filing 09 Sep 2020 04 Sep 2020 001-36818
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SC 13G Open Document Open Filing 01 Sep 2020
4 Open Document Open Filing 31 Aug 2020 27 Aug 2020 001-36818
3 Open Document Open Filing 31 Aug 2020 27 Aug 2020 001-36818
SC 13G Open Document Open Filing 28 Aug 2020
SC 13G Open Document Open Filing 21 Aug 2020
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13F-HR Open Document Open Filing 14 Aug 2020 30 Jun 2020 028-15896
4 Open Document Open Filing 14 Jul 2020 10 Jul 2020 001-35814
4 Open Document Open Filing 09 Jul 2020 07 Jul 2020 001-35814
4 Open Document Open Filing 23 Jun 2020 19 Jun 2020 001-35814
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SC 13G/A Open Document Open Filing 26 May 2020
4 Open Document Open Filing 22 May 2020 20 May 2020 001-35814
3 Open Document Open Filing 22 May 2020 14 May 2020 001-35814
13F-HR Open Document Open Filing 15 May 2020 31 Mar 2020 028-15896
SC 13G/A Open Document Open Filing 07 Apr 2020
3 Open Document Open Filing 06 Apr 2020 26 Mar 2020 001-38738
4 Open Document Open Filing 03 Apr 2020 03 Apr 2020 001-36554
SC 13G Open Document Open Filing 30 Mar 2020
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13F-HR Open Document Open Filing 14 Feb 2020 31 Dec 2019 028-15896
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SC 13G Open Document Open Filing 21 Jan 2020
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4 Open Document Open Filing 03 Jan 2020 02 Jan 2020 001-36554
4 Open Document Open Filing 02 Jan 2020 30 Dec 2019 001-36554
3 Open Document Open Filing 27 Dec 2019 17 Dec 2019 001-36554
SC 13G Open Document Open Filing 27 Dec 2019
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13F-HR Open Document Open Filing 14 Nov 2019 30 Sep 2019 028-15896
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13F-HR Open Document Open Filing 14 Aug 2019 30 Jun 2019 028-15896
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13F-HR Open Document Open Filing 14 Nov 2018 30 Sep 2018 028-15896
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SC 13G Open Document Open Filing 17 Apr 2017
SC 13G/A Open Document Open Filing SCHEDULE 13G AMENDMENT NO. 2 23 Feb 2017
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4/A Open Document Open Filing OWNERSHIP DOCUMENT 14 Mar 2016 11 Mar 2016 001-35814
4/A Open Document Open Filing OWNERSHIP DOCUMENT 14 Mar 2016 11 Mar 2016 001-35814
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4 Open Document Open Filing OWNERSHIP DOCUMENT 30 Jun 2015 30 Jun 2015 001-35814
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4 Open Document Open Filing OWNERSHIP DOCUMENT 20 May 2015 19 May 2015 001-35814
3 Open Document Open Filing OWNERSHIP DOCUMENT 20 May 2015 18 May 2015 001-35814
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