Insider Trading & Ownership of Opaleye Management Inc.

Location
Boston, MA
Summary
The estimated value of insider holdings of Opaleye Management Inc. is at least $231,131,258 dollars as of 06 Jan 2026. Opaleye Management Inc. is the 10%+ Owner of HARROW, INC. and owns shares of HARROW, INC. (HROW) stock worth about $104.48M. Opaleye Management Inc. is the 10%+ Owner of Eton Pharmaceuticals, Inc. and owns shares of Eton Pharmaceuticals, Inc. (ETON) stock worth about $45.18M. Opaleye Management Inc. is the 10%+ Owner of SANUWAVE Health, Inc. and owns shares of SANUWAVE Health, Inc. (SNWV) stock worth about $29.82M. Opaleye Management Inc. is the 10%+ Owner of Sol-Gel Technologies Ltd. and owns shares of Sol-Gel Technologies Ltd. (SLGL) stock worth about $19.65M. Opaleye Management Inc. is the 10%+ Owner of CODEXIS, INC. and owns shares of CODEXIS, INC. (CDXS) stock worth about $16.9M. Opaleye Management Inc. is the Former 10% Owner. of TELA Bio, Inc. and owns shares of TELA Bio, Inc. (TELA) stock worth about $11.71M. Opaleye Management Inc. is the 10%+ Owner of Protara Therapeutics, Inc. and owns shares of Protara Therapeutics, Inc. (TARA) stock worth about $3.4M.
Signature
Opaleye Management Inc., By: /s/ James Silverman, President
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Ownership of Opaleye Management Inc.

Symbol Company Relationship Holdings Value Past Year Net Change Change % Report Period
HROW, HROWL HARROW, INC. 10%+ Owner $104,480,098 -$2,908,329 -2.7% 09 Jun 2025
ETON Eton Pharmaceuticals, Inc. 10%+ Owner $45,177,234 +$125,484 +0.28% 10 Jun 2025
SNWV SANUWAVE Health, Inc. 10%+ Owner $29,818,165 +$242,236 +0.82% 06 Oct 2025
SLGL Sol-Gel Technologies Ltd. 10%+ Owner $19,646,286 +$3,658,443 +23% 02 Jan 2026
CDXS CODEXIS, INC. 10%+ Owner $16,900,093 +$8,303,033 +97% 26 Nov 2025
TELA TELA Bio, Inc. Former 10% Owner. $11,710,150 20 Apr 2023
TARA Protara Therapeutics, Inc. 10%+ Owner $3,399,232 11 Sep 2024
TCON Tracon Pharmaceuticals, Inc. 10%+ Owner 10 Nov 2023

Insider Transactions Reported by Opaleye Management Inc.:

Sym Company Class Transaction % Value $ * Price $ Shares Shares After Date Ownership
* An asterisk sign (*) next to the price indicates that the price is likely invalid.