Comparable stake leader
Opaleye Management Inc.
SEC ownership of Eton Pharmaceuticals, Inc.
Top holders, 13D/G large-stake signals, insider positions, and transaction flow tied to CIK 0001710340.
Disclosed value leader
Opaleye Management Inc.
Comparable rows
3/50
Latest evidence
06 Oct 2026
- Public ticker
- ETON on Nasdaq
- Parsed ownership sources
-
13D/G, 3/4/5, and 13F
Source: Parsed SEC ownership filingsUse: Compare filing families carefully
- Largest SEC-reported holder
-
Opaleye Management Inc.
Ranking: Comparable ownership first, then disclosed value
- Comparable ownership rows
-
3 of 50
Meaning: Rows with safely comparable ownership %
- Latest 13D/G holder
-
Opaleye Management Inc.
Source: Latest parsed Schedule 13D/G stake
- Latest parsed ownership date
-
06 Oct 2026
Freshness: Most recent filing date in this holder set
- Issuer CIK
- 0001710340
- Issuer location
- Deer Park, IL
Ownership snapshot
CIK-linked ownership evidence from parsed SEC filings.
3 signals
Issuer
Names, identifiers, and filing context for this profile.
2 identity fields
Ownership snapshot
Top shareholders of Eton Pharmaceuticals, Inc. (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
Opaleye Management Inc.
Disclosed value leader
Opaleye Management Inc.
Comparable rows
3/50
Latest evidence
06 Oct 2026
13D/G
3/4/5
13F
Lead comparable stake: 8.5%
47 rows are not safely comparable across share classes.
13D/G row: Opaleye Management Inc.
Showing 1-8 of 50 holder rows.
Quick read
Opaleye Management Inc. leads the comparable SEC ownership view at 8.5%.
3 of 50 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens Opaleye Management Inc.'s linked filing trail.
Comparable ownership
Top 3
Opaleye Management Inc.
8.5%
EcoR1 Capital, LLC
7.7%
BlackRock, Inc.
6.9%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-8 of 50 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| Opaleye Management Inc. |
13D/G
3/4/5
10%+ Owner
|
8.5%
Reported 13D/G
· 30 Sep 2026
|
$125,635,600
2,440,000 shares
|
$0 | 30 Sep 2026 |
| EcoR1 Capital, LLC |
13D/G
|
7.7%
Reported 13D/G
· 31 Dec 2024
|
$28,407,583
1,981,003 shares
|
$0 | 31 Dec 2024 |
| BlackRock, Inc. |
13D/G
|
6.9%
Reported 13D/G
· 30 Jun 2026
|
$68,143,242
1,882,410 shares
|
+$12,744,319 | 30 Jun 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC |
13F
Company
|
—
denominator unverified
|
$61,960,080
1,203,342 shares
|
— | 30 Sep 2026 |
| Sean Brynjelsen |
3/4/5
President & CEO, Director
|
—
mixed-class rows
|
$60,284,064
4,008,506 shares
mixed-class rows
|
-$9,913,490 | 19 Aug 2026 |
| Nantahala Capital Management, LLC |
13F
Company
|
—
denominator unverified
|
$45,079,855
875,507 shares
|
— | 30 Sep 2026 |
| STATE STREET CORP |
13F
Company
|
—
denominator unverified
|
$39,932,709
775,543 shares
|
— | 30 Sep 2026 |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
Company
|
—
denominator unverified
|
$39,368,003
764,398 shares
|
— | 30 Sep 2026 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
Forms 3/4/5 flow
Insider trading overview
Net insider flow leans to selling over the last 12 months. Net value: -$30,989,615.
Buys
$0
Insiders: 0
Sells
$30,989,615
Insiders: 7
Net
-$30,989,615
Shares: -688,221
Window
Last 12 months
4 rolling buckets
Buy value
Sell value
Shares: 0
Shares: 688,221
| Window (months) | Buy shares | Sell shares | Buy value | Sell value | Net value |
|---|---|---|---|---|---|
| 0-3 | 0 | 263,221 | $0 | $16,478,510 | -$16,478,510 |
| 3-6 | 0 | 425,000 | $0 | $14,511,105 | -$14,511,105 |
| 6-9 | 0 | 0 | $0 | $0 | $0 |
| 9-12 | 0 | 0 | $0 | $0 | $0 |
Reporting owners
Insider holders from Forms 3/4/5
Showing 1-12 of 12 reporting-owner rows connected to Eton Pharmaceuticals, Inc.. Open a relationship link for the CIK-to-CIK filing trail.
Rows
12
Largest Forms 3/4/5 holder
Opaleye Management Inc.
Net 12M change
-$30.99M
Full value: -$30,989,615 · USD · 12-month changeLatest report
10 Nov 2026
| Name | Relationship | Holdings Value | Past Year Net Change | Change % | Valuation | Report Date |
|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 10%+ Owner | $102,899,116 | -$5,831,670 | -5.4% | Filing P/S | 14 Jul 2026 |
| Sean Brynjelsen | President & CEO, Director | $60,284,064 | -$9,913,490 | -14% | Mixed | 19 Aug 2026 |
| Norbert G. Riedel | Director | $5,535,723 | Mixed | 31 Jul 2026 | ||
| James R. Gruber | Chief Financial Officer | $3,508,134 | Mixed | 12 Jan 2026 | ||
| Paul Maier V | Director | $2,615,269 | -$2,953,572 | -53% | Mixed | 28 Aug 2026 |
| David Krempa | Chief Business Officer | $2,595,358 | -$5,086,079 | -66% | Mixed | 06 Oct 2026 |
| Danka Radosavljevic | Chief Operating Officer | $813,522 | Mixed | 31 Jul 2026 | ||
| Ipek Erdogan-Trinkaus | Chief Commercial Officer | $277,012 | -$235,937 | -46% | Filing P/S | 10 Nov 2026 |
| Judith M. Matthews | Chief Financial Officer | $142,527 | Mixed | 31 Jul 2026 | ||
| Charles J. Casamento | Director | $0 | -$5,345,072 | -100% | Mixed | 10 Nov 2026 |
| Jennifer McKie Adams | Director | $0 | -$1,623,795 | -100% | Mixed | 31 Jul 2026 |
| William Wilson Troutman | CFO and Secretary | Mixed | 07 Feb 2022 |
Recent insider transactions for Eton Pharmaceuticals, Inc.
Showing up to 300 recent insider transactions from the last 12 months.
| Insider | Symbol | Class | Transaction | % | SEC-reported value | SEC-reported price | Shares | Shares owned | Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|---|
| Ipek Erdogan-Trinkaus | ETON | Common Stock | Sale | -46.2% | -$235,937 | $67.41 | -3,500 | 4,081 | 10 Nov 2026 | Direct |
| Ipek Erdogan-Trinkaus | ETON | Common Stock | Options Exercise | 85.8% | 3,500 | 7,581 | 10 Nov 2026 | Direct | ||
| Ipek Erdogan-Trinkaus | ETON | Employee Stock Option | Options Exercise | -8.61% | -3,500 | 37,155 | 10 Nov 2026 | Direct | ||
| Charles J. Casamento | ETON | Common Stock | Sale | -100% | -$5,345,072 | $66.35 | -80,555 | 0 | 10 Nov 2026 | Direct |
| Charles J. Casamento | ETON | Common Stock | Options Exercise | 80,555 | 80,555 | 10 Nov 2026 | Direct | |||
| Charles J. Casamento | ETON | Stock Option | Options Exercise | -100% | -80,555 | 0 | 10 Nov 2026 | Direct | ||
| David Krempa | ETON | Common Stock | Sale | -8.76% | -$229,406 | $55.07 | -4,166 | 43,381 | 06 Oct 2026 | Direct |
| David Krempa | ETON | Common Stock | Options Exercise | 28.4% | 10,522 | 47,547 | 02 Oct 2026 | Direct | ||
| David Krempa | ETON | Restricted Stock Units | Options Exercise | -33.3% | -10,522 | 21,044 | 02 Oct 2026 | Direct | ||
| Paul Maier V | ETON | Common Stock | Sale | -45.6% | -$2,953,572 | $59.07 | -50,000 | 59,745 | 28 Aug 2026 | Direct |
| Paul Maier V | ETON | Common Stock | Options Exercise | 132.3% | 62,500 | 109,745 | 28 Aug 2026 | Direct | ||
| Paul Maier V | ETON | Employee Stock Option | Options Exercise | 12,500 | 0 | 28 Aug 2026 | Direct | |||
| Paul Maier V | ETON | Employee Stock Option | Options Exercise | -100% | -50,000 | 0 | 28 Aug 2026 | Direct | ||
| David Krempa | ETON | Common Stock | Sale | -40.3% | -$1,626,750 | $65.07 | -25,000 | 37,025 | 24 Aug 2026 | Direct |
| David Krempa | ETON | Common Stock | Options Exercise | 67.5% | 25,000 | 62,025 | 24 Aug 2026 | Direct | ||
| David Krempa | ETON | Employee Stock Option | Options Exercise | -26.3% | -25,000 | 70,000 | 24 Aug 2026 | Direct | ||
| Sean Brynjelsen | ETON | Common Stock | Sale | -8.65% | -$5,525,301 | $60.70 | -91,022 | 961,194 | 20 Aug 2026 | Direct |
| Sean Brynjelsen | ETON | Common Stock | Sale | -0.85% | -$562,472 | $62.65 | -8,978 | 1,052,216 | 19 Aug 2026 | Direct |
| Charles J. Casamento | ETON | Common Stock | Award | 10,000 | 10,000 | 31 Jul 2026 | Direct | |||
| Judith M. Matthews | ETON | Common Stock | Award | 32,246 | 32,246 | 31 Jul 2026 | Direct | |||
| Ipek Erdogan-Trinkaus | ETON | Common Stock | Award | 80,000 | 80,000 | 31 Jul 2026 | Direct | |||
| Sean Brynjelsen | ETON | Common Stock | Award | 128,985 | 128,985 | 31 Jul 2026 | Direct | |||
| David Krempa | ETON | Common Stock | Award | 128,985 | 128,985 | 31 Jul 2026 | Direct | |||
| Paul Maier V | ETON | Common Stock | Award | 10,000 | 10,000 | 31 Jul 2026 | Direct | |||
| Norbert G. Riedel | ETON | Common Stock | Award | 10,000 | 10,000 | 31 Jul 2026 | Direct | |||
| Jennifer McKie Adams | ETON | Common Stock | Award | 10,000 | 10,000 | 31 Jul 2026 | Direct | |||
| Opaleye Management Inc. | ETON | Common Stock, par value $0.001 per share | Sale | -25% | -$499,886 | $37.54 | -13,315 | 40,000 | 14 Jul 2026 | By Managed Account |
| Opaleye Management Inc. | ETON | Common Stock, par value $0.001 per share | Sale | -0.56% | -$563,146 | $37.54 | -15,000 | 2,665,000 | 14 Jul 2026 | By Opaleye, L.P. |
| Sean Brynjelsen | ETON | Common Stock | Options Exercise | 23.2% | 200,000 | 1,061,194 | 14 Jul 2026 | Direct | ||
| Sean Brynjelsen | ETON | Employee Stock Option | Options Exercise | 200,000 | 0 | 14 Jul 2026 | Direct | |||
| Sean Brynjelsen | ETON | Common Stock | Options Exercise | 3.3% | 27,500 | 861,194 | 12 Jul 2026 | Direct | ||
| Sean Brynjelsen | ETON | Restricted Stock Units | Options Exercise | -100% | -27,500 | 0 | 12 Jul 2026 | Direct | ||
| David Krempa | ETON | Common Stock | Options Exercise | 37% | 10,000 | 37,025 | 12 Jul 2026 | Direct | ||
| David Krempa | ETON | Restricted Stock Units | Options Exercise | -100% | -10,000 | 0 | 12 Jul 2026 | Direct | ||
| Opaleye Management Inc. | ETON | Common Stock, par value $0.001 per share | Sale | -11.1% | -$256,522 | $38.37 | -6,685 | 53,315 | 07 Jul 2026 | By Managed Account |
| Opaleye Management Inc. | ETON | Common Stock, par value $0.001 per share | Sale | -0.74% | -$767,456 | $38.37 | -20,000 | 2,680,000 | 07 Jul 2026 | By Opaleye, L.P. |
| Opaleye Management Inc. | ETON | Common Stock, par value $0.001 per share | Sale | -0.37% | -$380,000 | $38.00 | -10,000 | 2,700,000 | 06 Jul 2026 | By Opaleye, L.P. |
| Opaleye Management Inc. | ETON | Common Stock, par value $0.001 per share | Sale | -29.4% | -$934,628 | $37.39 | -25,000 | 60,000 | 02 Jul 2026 | By Managed Account |
| Opaleye Management Inc. | ETON | Common Stock, par value $0.001 per share | Sale | -2.34% | -$2,430,032 | $37.39 | -65,000 | 2,710,000 | 02 Jul 2026 | By Opaleye, L.P. |
| David Krempa | ETON | Restricted Stock Units | Award | 11.5% | 10,000 | 96,829 | 26 Jun 2026 | Direct | ||
| Jennifer McKie Adams | ETON | Common Stock | Sale | -100% | -$1,623,795 | $32.48 | -50,000 | 0 | 17 Jun 2026 | Direct |
| Jennifer McKie Adams | ETON | Common Stock | Options Exercise | 50,000 | 50,000 | 17 Jun 2026 | Direct | |||
| Jennifer McKie Adams | ETON | Employee Stock Option | Options Exercise | -100% | -50,000 | 0 | 17 Jun 2026 | Direct | ||
| Sean Brynjelsen | ETON | Common Stock | Sale | -12.6% | -$3,825,717 | $31.88 | -120,000 | 833,694 | 28 May 2026 | Direct |
| David Krempa | ETON | Common Stock | Sale | -43.8% | -$619,375 | $31.47 | -19,679 | 25,249 | 27 May 2026 | Direct |
| David Krempa | ETON | Common Stock | Options Exercise | 77.9% | 19,679 | 44,928 | 27 May 2026 | Direct | ||
| David Krempa | ETON | Employee Stock Option | Options Exercise | -100% | -19,679 | 0 | 27 May 2026 | Direct | ||
| David Krempa | ETON | Common Stock | Sale | -59.8% | -$1,181,732 | $31.49 | -37,524 | 25,249 | 26 May 2026 | Direct |
| David Krempa | ETON | Common Stock | Options Exercise | 148.6% | 37,524 | 62,773 | 26 May 2026 | Direct | ||
| David Krempa | ETON | Employee Stock Option | Options Exercise | -100% | -37,524 | 0 | 26 May 2026 | Direct |
* marks a reported price that did not pass the local price check.