Security key
85209E208
SPRUCE BIOSCIENCES, INC. - Common Stock, par value $0.0001 per share (SPRB)
CUSIP: 85209E208
Q4 2025 13F Holders as of 31 Dec 2025
- Type / Class
- Equity / Common Stock, par value $0.0001 per share
- Shares outstanding
- 1,373,497
- Total 13F shares
- 753,855
- Share change
- -2,256,040
- Total reported value
- $65,599,507
- Price per share
- $87.11
- Number of holders
- 32
- Value change
- -$189,602,432
- Number of buys
- 27
- Number of sells
- 3
Report period
Q4 2025
Institutions
32
Top holders
10
SPRB full security history
Newer quarter: Q1 2026
Previous quarter: Q3 2025
SPRUCE BIOSCIENCES, INC. SEC filings
SPRUCE BIOSCIENCES, INC. company facts
Broader feeds
Reporting periods
Holder history for CUSIP 85209E208
Recent filing periods:
Top shareholders of SPRB - SPRUCE BIOSCIENCES, INC. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC |
13D/G
13F
|
Company |
11%
|
121,356
|
$1,060,227 | $0 | 31 Oct 2025 | |
| CITADEL ADVISORS LLC |
13D/G
|
Kenneth Griffin |
6.5%
|
70,035
|
$5,707,852 | -$3,228,541 | 31 Dec 2025 | |
| Boone Peter David Mr |
13D/G
|
— |
6.4%
|
68,184
|
$8,045,712 | $0 | 21 Nov 2025 | |
| WELLINGTON MANAGEMENT GROUP LLP |
13D/G
|
— |
5.5%
|
58,949
|
$4,804,344 | $0 | 31 Dec 2025 | |
| ADAR1 Capital Management, LLC |
13D/G
|
— |
5.4%
|
58,000
|
$4,796,020 | $0 | 31 Dec 2025 | |
| RiverVest Venture Fund III, L.P. |
13D/G
|
John P. McKearn, Ph.D. |
4.2%
|
1,759,521
|
$140,762 | $0 | 07 Jan 2025 | |
| HealthCap VIII, L.P. |
13D/G
|
— |
3.4%
|
36,640
|
$335,256 | $0 | 07 Oct 2025 | |
| Parkman Healthcare Partners LLC |
3/4/5
|
10%+ Owner |
0.08%
|
1,050
|
$18,328 | +$8,298 | 06 Oct 2025 | |
| Carlyle Group Inc. |
13F
|
Company |
211%
|
2,896,518
|
$24,765,229 | — | 30 Sep 2025 | |
| Cable Car Capital, LP |
13F
|
Company |
1.9%
|
26,666
|
$238,661 | — | 30 Sep 2025 | |
| Lion Point Capital, LP |
13F
|
Company |
0.07%
|
1,000
|
$8,950 | — | 30 Sep 2025 | |
| OSAIC HOLDINGS, INC. |
13F
|
Company |
0.01%
|
133
|
$931 | — | 30 Sep 2025 | |
| UBS Group AG |
13F
|
Company |
0.01%
|
132
|
$1,181 | — | 30 Sep 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.01%
|
98
|
$878 | — | 30 Sep 2025 | |
| CALDWELL SUTTER CAPITAL, INC. |
13F
|
Company |
0%
|
13
|
$116 | — | 30 Sep 2025 | |
| BANK OF AMERICA CORP /DE/ |
13F
|
Company |
0%
|
3
|
$27 | — | 30 Sep 2025 | |
| Novo Holdings A/S |
3/4/5
|
10%+ Owner |
—
class O/S missing
|
2,550,000
|
$1,924,485 | — | 21 Mar 2024 | |
| Samir M. Gharib |
3/4/5
|
PRESIDENT AND CFO |
—
mixed-class rows
|
9,290
mixed-class rows
|
$695,534 | — | 15 Dec 2025 | |
| Javier B. Szwarcberg |
3/4/5
|
CHIEF EXECUTIVE OFFICER, Director |
—
mixed-class rows
|
21,396
mixed-class rows
|
$253,640 | — | 31 Dec 2025 | |
| Douglas Kirk Ways |
3/4/5
|
Interim Chief Medical Officer, Director |
—
mixed-class rows
|
5,000
mixed-class rows
|
$91,912 | — | 11 Dec 2025 | |
| Ralph William Charlton III |
3/4/5
|
CHIEF MEDICAL OFFICER |
—
mixed-class rows
|
224,839
mixed-class rows
|
$87,394 | — | 10 Dec 2024 | |
| Subaweerage Dias |
3/4/5
|
Chief Medical Officer |
—
mixed-class rows
|
95,000
mixed-class rows
|
$33,200 | — | 16 Dec 2021 | |
| Richard King |
3/4/5
|
Chief Executive Officer, Director |
—
class O/S missing
|
2,230
|
$2,180 | — | 30 Jun 2021 | |
| Bali Muralidhar |
3/4/5
|
Director |
—
class O/S missing
|
30,000
|
— | — | 22 Jul 2025 | |
| Niall O'Donnell |
3/4/5
|
Director |
—
class O/S missing
|
30,000
|
— | — | 25 May 2023 | |
| Tiba Aynechi |
3/4/5
|
Director |
—
class O/S missing
|
30,000
|
— | — | 22 Jul 2025 | |
| Moghrabi Dina Chaya |
3/4/5
|
Director |
—
class O/S missing
|
22,500
|
— | — | 25 May 2022 |
Institutional Holders of SPRUCE BIOSCIENCES, INC. - Common Stock, par value $0.0001 per share (SPRB) as of Q4 2025
As of 31 Dec 2025,
SPRUCE BIOSCIENCES, INC. - Common Stock, par value $0.0001 per share (SPRB) was held by
32 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
753,855 shares.
The largest 10 holders included
Ikarian Capital, LLC, Squadron Capital Management LLC, CITADEL ADVISORS LLC, WELLINGTON MANAGEMENT GROUP LLP, ADAR1 Capital Management, LLC, Alyeska Investment Group, L.P., BOOTHBAY FUND MANAGEMENT, LLC, Balyasny Asset Management L.P., Carlyle Group Inc., and ExodusPoint Capital Management, LP.
This page lists
32
institutional shareholders reporting positions in this security
for the Q4 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
9
Q4 2025 holders
32
Holder diff
23
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 Value $ | Q4 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.