Ikarian Capital, LLC - Oct 31, 2025 SCHEDULE 13G/A Report for Spruce Biosciences Inc. Common Stock, par value $0.0001 per share (SPRB)

Filing Manager: Ikarian Capital, LLC
Reporting Manager: Ikarian Capital, LLC
Security: Spruce Biosciences Inc. Common Stock, par value $0.0001 per share
Symbol: SPRB
Shares outstanding: 1.06M shares
Disclosed Ownership: 121K shares
Ownership: 11.4%
Form type: SCHEDULE 13G/A
Date filed: 11/7/2025, 04:30 PM
Date of event: Oct 31, 2025
Previous filing: Oct 8, 2025
SEC: View on sec.gov

Reporting Managers (2)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
Ikarian Capital, LLC	11.4%	121K	0	121K	/s/ Neil Shahrestani	Neil Shahrestani, Sole Manager
Neil Shahrestani	11.4%	121K	0	121K	/s/ Neil Shahrestani	Neil Shahrestani