CASSAVA SCIENCES INC - Common Stock (SAVA) Institutional Ownership

13F Institutional Holders and Ownership History from Q1 2019 to Q4 2025

Type / Class: Equity / Common Stock
Symbol: SAVA on Nasdaq
Shares outstanding: 48,331,225
Price per share: $2.17
All holders as of 31 Dec 2025: Q4 2025
Total 13F shares: 13,705,063
Total reported value: $27,134,470
% of total 13F portfolios: 0%
Share change: +102,217
Value change: -$919,309
Number of holders: 98
Price from insider filings: $2.17

Reported Shares, Excluding Options vs Price

Reported Value, Excluding Options

Total Investors

Significant Owners of CASSAVA SCIENCES INC - Common Stock (SAVA) based on Schedule 13D/G filings

Filer	Ownership	Holdings Value	Nb Shares	Reporting Name	Report Period
Nachtrab Matthew	4.7%	$3,560,189	2,267,636	Nachtrab Matthew	16 Aug 2024
VANGUARD GROUP INC	4.5%	$3,927,830	2,170,072	The Vanguard Group	30 Jun 2025
BlackRock, Inc.	3.2%	$2,797,129	1,545,375	BlackRock, Inc.	30 Jun 2025

As of 31 Dec 2025, 98 institutional investors reported holding 13,705,063 shares of CASSAVA SCIENCES INC - Common Stock (SAVA). This represents 28% of the company’s total 48,331,225 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of CASSAVA SCIENCES INC - Common Stock (SAVA) together control 26% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution	Ownership %	Shares Held	Share Change %	Portfolio %	Holdings Value
VANGUARD GROUP INC	4.9%	2,375,589	+3.8%	0%	$4,703,666
MARSHALL WACE, LLP	4.4%	2,115,307	+2.6%	0%	$4,188,307
BlackRock, Inc.	2.9%	1,419,934	+0.76%	0%	$2,811,469
TWO SIGMA ADVISERS, LP	2%	954,800	-0.7%	0%	$1,890,504
TWO SIGMA INVESTMENTS, LP	1.3%	642,401	+14%	0%	$1,271,954
GEODE CAPITAL MANAGEMENT, LLC	1.1%	545,969	+1.5%	0%	$1,081,433
SUSQUEHANNA INTERNATIONAL GROUP, LLP	1.1%	528,018	+38%	0%	$1,045,476
JANE STREET GROUP, LLC	1.1%	513,137	+162%	0%	$1,016,011
D. E. Shaw & Co., Inc.	0.97%	469,326		0%	$929,266
Point72 Asset Management, L.P.	0.62%	299,579		0%	$593,166
GSA CAPITAL PARTNERS LLP	0.6%	287,879		0.05%	$570,000
ACADIAN ASSET MANAGEMENT LLC	0.59%	284,213	+1063%	0%	$561,000
MILLENNIUM MANAGEMENT LLC	0.57%	274,399	-14%	0%	$543,310
GROUP ONE TRADING LLC	0.56%	269,470	+34%	0.02%	$533,551
JACOBS LEVY EQUITY MANAGEMENT, INC	0.51%	246,987	+9.9%	0%	$489,034
STATE STREET CORP	0.44%	212,187	-0.4%	0%	$420,130
Susquehanna Portfolio Strategies, LLC	0.43%	206,835	0%	0.01%	$409,533
SIMPLEX TRADING, LLC	0.36%	173,065	+7%	0.01%	$342,668
NORTHERN TRUST CORP	0.31%	149,194	+14%	0%	$295,405
CANADA PENSION PLAN INVESTMENT BOARD	0.3%	144,100		0%	$285,318
DIMENSIONAL FUND ADVISORS LP	0.29%	140,057		0%	$277,313
Graham Capital Management, L.P.	0.27%	128,703	+9.1%	0.01%	$254,832
Connor, Clark & Lunn Investment Management Ltd.	0.21%	100,577		0%	$199,142
Jump Financial, LLC	0.19%	91,620		0%	$181,408
FEDERATED HERMES, INC.	0.19%	91,479	+111%	0%	$181,128

Institutional Holders of CASSAVA SCIENCES INC - Common Stock (SAVA) across Reporting Periods

Period	Reported Shares, Excl. Options	Value, Excl. Options	Value Change	Puts Notional Value	Calls Notional Value	Price (Median)	Investors
2025 Q4	13,705,063	$27,134,470	-$919,309	$1,405,998	$1,499,256	$1.98	98
2025 Q3	13,778,326	$40,074,441	+$5,019,405	$1,101,435	$2,913,492	$2.91	101
2025 Q2	12,246,863	$22,166,624	-$6,209,960	$815,233	$1,270,548	$1.81	96
2025 Q1	15,768,881	$23,653,533	-$3,650,996	$1,267,905	$2,012,355	$1.50	114
2024 Q4	17,411,806	$41,096,950	-$26,811,358	$17,862,520	$7,513,992	$2.36	135
2024 Q3	14,006,298	$412,343,524	+$21,408,686	$178,413,916	$80,685,694	$29.43	159
2024 Q2	13,297,542	$164,180,761	+$20,340,671	$18,969,600	$14,542,125	$12.35	140
2024 Q1	11,593,879	$235,338,414	-$49,008,344	$18,853,468	$27,133,817	$20.29	141
2023 Q4	13,929,974	$313,474,831	+$20,318,834	$40,085,808	$49,600,785	$22.51	150
2023 Q3	12,909,705	$214,797,641	+$17,325,070	$42,116,968	$45,163,488	$16.64	136
2023 Q2	11,697,131	$286,735,353	-$6,324,947	$34,543,534	$31,485,888	$24.52	150
2023 Q1	11,914,630	$287,373,528	+$15,058,161	$31,884,668	$32,313,212	$24.12	140
2022 Q4	11,254,249	$332,457,243	+$2,217,261	$72,843,064	$68,738,838	$29.54	146
2022 Q3	10,511,058	$439,522,416	+$28,422,554	$102,064,642	$142,913,972	$41.82	164
2022 Q2	9,860,019	$277,264,167	-$22,312,348	$72,704,904	$66,579,276	$28.12	136
2022 Q1	10,487,576	$389,768,314	-$39,764,775	$141,252,186	$78,442,360	$37.14	147
2021 Q4	11,534,283	$504,052,860	-$49,487,683	$195,963,000	$145,576,000	$43.70	160
2021 Q3	12,113,852	$751,991,955	+$67,636,793	$294,845,000	$265,558,000	$62.08	169
2021 Q2	10,434,065	$891,498,117	+$48,315,268	$123,442,600	$174,814,600	$85.44	163
2021 Q1	10,158,803	$456,594,941	+$91,884,258	$42,736,000	$58,038,050	$44.95	116
2020 Q4	9,404,804	$64,135,775	+$15,501,397	$3,228,000	$1,391,000	$6.82	70
2020 Q3	6,699,572	$77,113,513	+$9,133,318	$3,872,000	$6,323,000	$11.51	63
2020 Q2	5,994,033	$18,463,673	-$2,167,955	$734,000	$965,000	$3.08	47
2020 Q1	6,007,016	$24,760,000	+$5,851,160	$197,000	$521,000	$4.11	38
2019 Q4	4,360,623	$22,674,000	+$6,170,969			$5.20	27
2019 Q3	1,823,694	$2,188,000	-$1,850,994			$1.20	16
2019 Q2	3,351,011	$4,055,000	+$2,993			$1.21	20
2019 Q1	3,342,185	$4,312,000	+$4,312,000			$1.29	22