Security key
91678A107
Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)
CUSIP: 91678A107
Q2 2025 13F Holders as of 30 Jun 2025
- Security type / class
- Equity / Common Stock, par value $0.001 per share
- Total 13F shares
- 48,353,677
- Total 13F value
- $530,923,062
- Share change
- +2,883,110
- SEC-reported price per share
- $10.98
- Number of holders
- 82
- Value change
- +$32,738,813
- Number of buys
- 53
- Number of sells
- 22
- Shares outstanding
- 54,497,360
Holder snapshot
6 signals
Security identity
1 source field
Report period
Q2 2025
Institutions
82
Top holders
10
UPB full security history
Ownership snapshot
Full 13F holder table
Newer quarter: Q3 2025
Previous quarter: Q1 2025
Upstream Bio, Inc. SEC filings
Upstream Bio, Inc. company facts
Broader feeds
Reporting periods
Holder history for CUSIP 91678A107
Recent filing periods:
Ownership snapshot
Top reported holders of UPB - Upstream Bio, Inc. - Common Stock, par value $0.001 per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
FMR LLC
Disclosed value leader
FMR LLC
Comparable rows
15/15
Latest evidence
30 Jun 2025
13D/G
13F
3/4/5
Lead comparable stake: 15%
13D/G row: FMR LLC
Showing 1-6 of 15 holder rows.
Quick read
FMR LLC leads the comparable SEC ownership view at 15%.
15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Comparable ownership
Top 5
FMR LLC
15%
ORBIMED ADVISORS LLC
10%
Decheng Capital LLC
6%
Altshuler Shaham Ltd
5.9%
TCG Crossover Management, LLC
5.1%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-6 of 15 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| FMR LLC |
13D/G
13F
Company
|
15%
|
$93,972,663
7,936,880 shares
|
+$9,006,605 | 30 Jun 2025 |
| ORBIMED ADVISORS LLC |
13F
3/4/5
Company · Director, 10%+ Owner
|
10%
|
$34,844,765
5,693,589 shares
|
— | 31 Mar 2025 |
| Decheng Capital LLC |
13F
Company
|
6%
|
$20,105,993
3,285,293 shares
|
— | 31 Mar 2025 |
| Altshuler Shaham Ltd |
13F
Company
|
5.9%
|
$3,519,516
3,235,293 shares
|
— | 31 Mar 2025 |
| TCG Crossover Management, LLC |
13F
Company
|
5.1%
|
$17,146,790
2,801,763 shares
|
— | 31 Mar 2025 |
| Enavate Sciences GP, LLC |
13F
Company
|
4.5%
|
$15,053,382
2,459,703 shares
|
— | 31 Mar 2025 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
13F holder rows
Institutional holders as of Q2 2025
Investor-level positions for this CUSIP, loaded as an interactive table.
Institutions
82
Shares
48,353,677
Rows available
82
| Investor | Option | Weight % | Change % | SEC-reported value | * Price | Shares | Share Change | Activity | Report Period |
|---|
* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.
Compare Q2 2025 vs Q1 2025 Across Filers
Q1 2025 holders
76
Q2 2025 holders
82
Holder diff
6
| Investor | Q1 2025 Shares | Q2 2025 Shares | Share Diff | Share Chg % | Q1 2025 value | Q2 2025 value | Value change | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend