Upstream Bio, Inc. financial data

Symbol
UPB on Nasdaq
Location
Waltham, MA
Fiscal year end
31 December
Latest financial report
10-Q - Q3 2025 - 05 Nov 2025

Key Ratios

Label TTM Value / Value Unit Change %
Current Ratio 4034% %
Debt-to-equity 2.8% %
Return On Equity -29% % -176%
Return On Assets -28% %
Operating Margin -5020% %

Shares

Label TTM Value / Value Unit Change %
Entity Common Stock, Shares Outstanding 54,038,591 shares 0.82%
Common Stock, Shares, Outstanding 53,999,522 shares 1685%
Common Stock, Value, Issued $56,000 USD 1767%
Weighted Average Number of Shares Outstanding, Basic 53,930,946 shares 1684%
Weighted Average Number of Shares Outstanding, Diluted 53,930,946 shares 1684%

Income Statement

Label TTM Value / Value Unit Change %
Revenue from Contract with Customer, Excluding Assessed Tax $2,799,000 USD 13%
Research and Development Expense $118,410,000 USD 114%
General and Administrative Expense $24,901,000 USD 36%
Operating Income (Loss) $140,512,000 USD -100%
Nonoperating Income (Expense) $18,286,000 USD 41%
Income Tax Expense (Benefit) $0 USD
Net Income (Loss) Attributable to Parent $122,226,000 USD -129%
Earnings Per Share, Basic 10 USD/shares 91%
Earnings Per Share, Diluted 10 USD/shares 91%

Balance Sheet

Label TTM Value / Value Unit Change %
Cash and Cash Equivalents, at Carrying Value $72,164,000 USD 119%
Accounts Receivable, after Allowance for Credit Loss, Current $683,000 USD 13%
Assets, Current $389,017,000 USD 71%
Property, Plant and Equipment, Net $616,000 USD 6.6%
Operating Lease, Right-of-Use Asset $1,368,000 USD -29%
Goodwill $0 USD
Assets $391,195,000 USD 68%
Accounts Payable, Current $3,952,000 USD -19%
Employee-related Liabilities, Current $3,037,000 USD 52%
Liabilities, Current $11,908,000 USD 9.5%
Operating Lease, Liability, Noncurrent $703,000 USD -44%
Liabilities $12,611,000 USD 3.9%
Accumulated Other Comprehensive Income (Loss), Net of Tax $493,000 USD 40%
Retained Earnings (Accumulated Deficit) $291,764,000 USD -72%
Stockholders' Equity Attributable to Parent $378,584,000 USD
Liabilities and Equity $391,195,000 USD 68%

Popular Metrics

Label TTM Value / Value Unit Change %
Net Cash Provided by (Used in) Operating Activities $41,165,000 USD -134%
Net Cash Provided by (Used in) Financing Activities $34,000 USD -100%
Net Cash Provided by (Used in) Investing Activities $213,381,000 USD -1640%
Common Stock, Shares Authorized 500,000,000 shares 1129%
Common Stock, Shares, Issued 53,999,522 shares 1685%
Common Stock, Par or Stated Value Per Share 0 USD/shares 0%
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect $254,580,000 USD -4584%
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents $72,358,000 USD 118%
Deferred Tax Assets, Valuation Allowance $60,664,000 USD 53%
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent 0 pure
Deferred Tax Assets, Gross $61,152,000 USD 54%
Operating Lease, Liability $1,834,000 USD
Comprehensive Income (Loss), Net of Tax, Attributable to Parent $122,084,000 USD -115%
Lessee, Operating Lease, Liability, to be Paid $2,145,000 USD
Property, Plant and Equipment, Gross $903,000 USD 32%
Operating Lease, Liability, Current $716,000 USD 5.6%
Lessee, Operating Lease, Liability, to be Paid, Year Two $800,000 USD 0%
Lessee, Operating Lease, Liability, to be Paid, Year One $700,000 USD 0%
Operating Lease, Weighted Average Discount Rate, Percent 0.12 pure -25%
Lessee, Operating Lease, Liability, Undiscounted Excess Amount $311,000 USD
Lessee, Operating Lease, Liability, to be Paid, Year Three $800,000 USD 0%
Deferred Tax Assets, Operating Loss Carryforwards $10,994,000 USD 57%
Preferred Stock, Shares Issued 0 shares
Preferred Stock, Shares Authorized 10,000,000 shares
Unrecognized Tax Benefits $0 USD
Additional Paid in Capital $669,799,000 USD 7449%
Preferred Stock, Shares Outstanding 0 shares
Depreciation, Depletion and Amortization $43,000 USD 231%
Deferred Tax Assets, Net of Valuation Allowance $488,000 USD 3967%
Share-based Payment Arrangement, Expense $9,912,000 USD 39%
Preferred Stock, Par or Stated Value Per Share 0 USD/shares