Type / Class
Equity / Common Stock, par value $0.001 per share
Shares outstanding
54,284,692
Total 13F shares
44,461,719
Share change
-3,895,388
Total reported value
$836,327,467
Put/Call ratio
4.6%
Price per share
$18.81
Number of holders
94
Value change
-$50,813,162
Number of buys
59
Number of sells
32

Institutional Holders of Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB) as of Q3 2025

As of 30 Sep 2025 Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB) had 94 institutional shareholders that have filed 13F forms with the Securities Exchange Commission (SEC). These institutions held a total of 44,461,719 shares of stock of the company.
Largest 10 holders included FMR LLC, ORBIMED ADVISORS LLC, Decheng Capital LLC, BlackRock, Inc., ENAVATE SCIENCES GP, LLC, VANGUARD GROUP INC, Bain Capital Life Sciences Investors, LLC, TCG Crossover Management, LLC, Altshuler Shaham Ltd, and Omega Fund Management, LLC.
This table shows 94 institutional shareholders of the security as of 30 Sep 2025.
Investor Option Weight % Change % Value $ * Price $ Shares Share Change Activity Report Period
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.