Latest Period
Q2 2026
Security Snapshot
Upstream Bio, Inc. - Common Stock (UPB) Institutional Ownership
CUSIP: 91678A107
13F Institutional Holders and Ownership History from Q4 2024 to Q2 2026
Institutions Reporting
37
Shares (Excl. Options)
7,360,611
Price
$6.92
Save this security page for your next review
Keep this CUSIP in your watchlists so you can revisit quarter changes from one place. If you create an account from here, we will bring you back after verification.
- Security type / class
- Equity / Common Stock
- Symbol
- UPB on Nasdaq
- All holders as of 30 Jun 2026
- Q2 2026
- Total 13F shares
- 7,360,611
- Total 13F value
- $50,941,904
- Portfolio coverage rank
- 0%
- Share change
- +115,746
- Value change
- -$834,142
- Number of holders
- 37
- Shares outstanding
- 54,129,115
- SEC-reported price per share
- $7.98
Latest holder snapshot
5 signals
Issuer context
Names, identifiers, and filing context for this profile.
2 identity fields
13F Shares, Excluding Options vs Price
13F Value, Excluding Options
Total Investors
Key facts
- UPB - Upstream Bio, Inc. - Common Stock is tracked under CUSIP 91678A107.
- 37 institutions reported positions in Q2 2026.
- 6 significant owners is listed from Schedule 13D/13G reporting.
Change
- Holder count moved from 138 to 37 between Q1 2026 and Q2 2026.
- SEC-reported value moved from $403,623,162 to $50,941,904.
Research use
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Evidence
Source: SEC Form 13F
Open SEC evidence
Latest holder context comes from 37 institutions filings for Q2 2026.
Security key
91678A107
Latest holder period
Q2 2026
13F holders
37
13D/G owners
6
CIK / CUSIP context first
Open Q2 2026 holders
UPB full holder history
Upstream Bio, Inc. SEC filings
Upstream Bio, Inc. company facts
Upstream Bio, Inc. insider transactions
Broader feeds
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 91678A107:
13D/G owners
Significant owners
Large-stake holder rows connected to Schedule 13D/G evidence.
Rows
6
Security
UPB
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| FMR LLC | 15% | +11% | $93,972,663 | +$9,006,605 | 7,936,880 | +11% | FMR LLC | 30 Jun 2025 |
| NORGES BANK | 5.3% | $54,226,626 | 2,882,647 | Norges Bank | 30 Sep 2025 | |||
| BlackRock, Inc. | 5.2% | $19,477,821 | 2,814,714 | BlackRock, Inc. | 30 Jun 2026 | |||
| Decheng Capital Global Life Sciences Fund IV, L.P. | 5% | -18% | $25,886,246 | -$5,324,038 | 2,724,868 | -17% | Decheng Capital Global Life Sciences Fund IV, L.P. | 31 Mar 2026 |
| HBM Healthcare Investments (Cayman) Ltd. | 4.1% | -20% | $41,290,257 | -$9,780,217 | 2,195,111 | -19% | HBM Healthcare Investments (Cayman) Ltd. | 30 Sep 2025 |
| TCG Crossover GP I, LLC | 3.9% | -26% | $39,822,919 | -$12,878,523 | 2,117,103 | -24% | TCG Crossover GP I, LLC | 30 Sep 2025 |
As of 30 Jun 2026, 37 institutional investors reported holding 7,360,611 shares of Upstream Bio, Inc. - Common Stock (UPB). This represents 14% of the company’s total 54,129,115 outstanding shares.
13F concentration
Top 25 institutional shareholders
Largest 13F positions for this security by reported shares and value.
Top holder share
14%
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| BlackRock, Inc. | 6.9% | 3,753,358 | +11% | 0% | $25,973,237 |
| SEB Asset Management AB | 1.6% | 878,473 | 0% | 0.02% | $6,079,022 |
| STATE STREET CORP | 1.4% | 766,323 | +8.6% | 0% | $5,302,955 |
| Y-Intercept (Hong Kong) Ltd | 1.3% | 693,555 | -31% | 0.09% | $4,799,401 |
| Walleye Capital LLC | 0.92% | 498,490 | 0.02% | $3,449,551 | |
| DEUTSCHE BANK AG\ | 0.45% | 241,447 | +33% | 0% | $1,670,814 |
| Bank of New York Mellon Corp | 0.16% | 85,747 | +5.4% | 0% | $593,369 |
| GSA CAPITAL PARTNERS LLP | 0.13% | 69,348 | +77% | 0.03% | $480,000 |
| Simplify Asset Management Inc. | 0.11% | 62,113 | -20% | 0.01% | $429,822 |
| ALPS ADVISORS INC | 0.1% | 55,228 | +26% | 0% | $382,178 |
| Russell Investments Group, Ltd. | 0.09% | 47,543 | +1204% | 0% | $329,000 |
| CITIGROUP INC | 0.07% | 40,339 | +698% | 0% | $279,145 |
| AXQ CAPITAL, LP | 0.05% | 27,068 | -1.6% | 0.02% | $187,311 |
| nVerses Capital, LLC | 0.04% | 24,029 | 0.26% | $166,280 | |
| SG Americas Securities, LLC | 0.04% | 20,338 | 0% | $141,000 | |
| WINTON GROUP Ltd | 0.04% | 19,800 | 0% | $137,016 | |
| Quadrature Capital Ltd | 0.03% | 17,988 | 0% | $124,477 | |
| STRS OHIO | 0.02% | 12,000 | +22% | 0% | $83,040 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0.02% | 10,017 | 0% | $75,428 | |
| Police & Firemen's Retirement System of New Jersey | 0.02% | 9,456 | 0% | 0% | $65,436 |
| China Universal Asset Management Co., Ltd. | 0.02% | 8,661 | -9.7% | 0% | $59,934 |
| NEW YORK STATE COMMON RETIREMENT FUND | 0.01% | 5,200 | +5100% | 0% | $35,984 |
| Persistent Asset Partners Ltd | 0.01% | 4,855 | -12% | 0.01% | $33,597 |
| Mirae Asset Global Investments Co., Ltd. | 0% | 2,434 | -14% | 0% | $16,843 |
| Global Retirement Partners, LLC | 0% | 1,870 | +585% | 0% | $12,940 |
Quarter history
Institutional holders across reporting periods
Holder count, reported shares/value, and median price by quarter.
Periods
7
Latest
Q2 2026
Rows shown
1-7 of 7
| Period | 13F Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q2 | 7,360,611 | $50,941,904 | -$834,142 | $6.92 | 37 |
| 2026 Q1 | 44,855,500 | $403,623,162 | -$257,351,863 | $9.00 | 138 |
| 2025 Q4 | 51,176,304 | $1,389,381,175 | +$178,186,919 | $27.15 | 133 |
| 2025 Q3 | 44,461,719 | $836,327,467 | -$50,813,162 | $18.81 | 94 |
| 2025 Q2 | 48,353,677 | $530,923,062 | +$32,738,813 | $10.98 | 82 |
| 2025 Q1 | 42,073,968 | $257,482,324 | -$17,702,490 | $6.12 | 76 |
| 2024 Q4 | 42,074,592 | $690,108,943 | +$649,643,232 | $16.44 | 70 |