Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Historical Holders from Q4 2024 to Q3 2025

Symbol
UPB on Nasdaq
Type / Class
Equity / Common Stock, par value $0.001 per share
Shares outstanding
54,284,692
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares, excl. options
44,461,719
Holdings value
$836,327,467
% of all portfolios
0.003%
Number of holders
94
Number of buys
59
Number of sells
-32
Average buys %
+0%
Average sells %
-0%
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
FMR LLC 14.8% +10.8% $93,972,663 +$9,006,605 7,936,880 +10.6% FMR LLC 30 Jun 2025
Decheng Capital Global Life Sciences Fund IV, L.P. 6.1% $29,501,931 3,285,293 Xiangmin Cui 31 Dec 2024
NORGES BANK 5.3% $54,226,626 2,882,647 Norges Bank 30 Sep 2025
HBM Healthcare Investments (Cayman) Ltd. 4.1% -20% $41,290,257 -$9,780,217 2,195,111 -19.2% HBM Healthcare Investments (Cayman) Ltd. 30 Sep 2025
TCG Crossover GP I, LLC 3.9% -26% $39,822,919 -$12,878,523 2,117,103 -24.4% TCG Crossover GP I, LLC 30 Sep 2025

Institutional Holders of Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Period Reported Shares, Excl. Options Value, Excl. Options Change Price Investors
2025 Q3 44,461,719 $836,327,467 -$50,813,162 $18.81 94
2025 Q2 48,353,677 $530,923,062 +$32,738,813 $10.98 82
2025 Q1 42,073,968 $257,482,324 -$17,702,490 $6.12 76
2024 Q4 42,074,592 $690,108,943 +$649,643,232 $16.44 70