HBM Healthcare Investments (Cayman) Ltd. - 30 Sep 2025 SCHEDULE 13G/A Report for Upstream Bio, Inc. Common Stock, par value $0.001 per share (UPB)

Filing Manager: HBM Healthcare Investments (Cayman) Ltd.
Reporting Manager: HBM Healthcare Investments (Cayman) Ltd.
Security: Upstream Bio, Inc. Common Stock, par value $0.001 per share
Symbol: UPB
Shares outstanding: 53.5M shares
Disclosed Ownership: 2.2M shares
Ownership: 4.1%
Form type: SCHEDULE 13G/A
Filing time: 14 Nov 2025, 16:05:34 UTC
Date of event: 30 Sep 2025
Previous filing: 13 Feb 2025
SEC: View on sec.gov

Reporting Managers (1)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
HBM Healthcare Investments (Cayman) Ltd.	4.1%	2.2M	2.2M	0	/s/ Jean-Marc LeSieur	Jean-Marc LeSieur, Managing Director