Security key
877619106
Taysha Gene Therapies, Inc. - Common Stock, $0.00001 par value per share (TSHA)
CUSIP: 877619106
Q4 2025 13F Holders as of 31 Dec 2025
- Security type / class
- Equity / Common Stock, $0.00001 par value per share
- Total 13F shares
- 269,009,134
- Total 13F value
- $1,479,387,583
- Share change
- +6,395,054
- Put/Call ratio
- 16%
- SEC-reported price per share
- $5.50
- Number of holders
- 195
- Value change
- +$50,473,906
- Number of buys
- 121
- Number of sells
- 68
- Shares outstanding
- 332,184,263
Holder snapshot
7 signals
Open additional details 1 more signal available
Security identity
Names, identifiers, and filing context for this profile.
1 source field
Report period
Q4 2025
Institutions
195
Top holders
10
TSHA full security history
Ownership snapshot
Full 13F holder table
Taysha Gene Therapies, Inc. SEC filings
Taysha Gene Therapies, Inc. company facts
Broader feeds
Ownership snapshot
Top reported holders of TSHA - Taysha Gene Therapies, Inc. - Common Stock, $0.00001 par value per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
Paul B. Manning
Disclosed value leader
BlackRock, Inc.
Comparable rows
15/15
Latest evidence
31 Dec 2025
13D/G
3/4/5
13F
Lead comparable stake: 9.8%
13D/G row: Paul B. Manning
Showing 1-6 of 15 holder rows.
Quick read
Paul B. Manning leads the comparable SEC ownership view at 9.8%.
15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens Paul B. Manning's linked filing trail.
Comparable ownership
Top 5
Paul B. Manning
9.8%
BlackRock, Inc.
6.5%
GOLDMAN SACHS GROUP INC
5.1%
FMR LLC
4.9%
Octagon Capital Advisors LP
3.3%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-6 of 15 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| Paul B. Manning |
13D/G
3/4/5
10%+ Owner
|
9.8%
|
$59,394,578
25,601,111 shares
|
$0 | 30 May 2025 |
| BlackRock, Inc. |
13D/G
13F
Company
|
6.5%
|
$98,187,600
17,852,291 shares
|
+$25,844,308 | 31 Dec 2025 |
| GOLDMAN SACHS GROUP INC |
13F
13D/G
Company · THE GOLDMAN SACHS GROUP, INC.
|
5.1%
from 13D/G
|
$43,764,725
13,383,708 shares
|
— | 30 Sep 2025 |
| FMR LLC |
13D/G
13F
Company
|
4.9%
|
$74,406,012
13,528,366 shares
|
-$11,547,008 | 31 Dec 2025 |
| Octagon Capital Advisors LP |
13D/G
13F
Company
|
3.3%
|
$29,650,725
9,067,500 shares
|
-$4,520,775 | 30 Sep 2025 |
| RTW INVESTMENTS, LP |
13F
Company
|
7.3%
|
$79,638,532
24,354,291 shares
|
— | 30 Sep 2025 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
13F holder rows
Institutional holders as of Q4 2025
Investor-level positions for this CUSIP, loaded as an interactive table.
Institutions
195
Shares
269,009,134
Rows available
195
| Investor | Option | Weight % | Change % | SEC-reported value | * Price | Shares | Share Change | Activity | Report Period |
|---|
* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
152
Q4 2025 holders
195
Holder diff
43
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 value | Q4 2025 value | Value change | Value Chg % |
|---|