Paul B Manning - 30 May 2025 SCHEDULE 13D/A Report for TAYSHA GENE THERAPIES, INC. Common Stock, $0.00001 par value per share (TSHA)

Filing Manager: Paul B Manning
Reporting Manager: Paul B Manning
Security: TAYSHA GENE THERAPIES, INC. Common Stock, $0.00001 par value per share
Symbol: TSHA
Shares outstanding: 261,235,827 shares
Disclosed Ownership: 25,601,111 shares
Ownership: 9.8%
Form type: SCHEDULE 13D/A
Filing time: 03 Jun 2025, 21:54:54 UTC
Date of event: 30 May 2025
SEC: View on sec.gov

Reporting Managers (6)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
Paul B Manning	9.8%	25,601,111	22,737,407	2,863,704	Paul B. Manning	Paul B. Manning	0001494695
The Paul B. Manning Revocable Trust dated May 10, 2000	5.6%	14,723,948	14,723,948	0	Paul B. Manning	Paul B. Manning, Trustee	0000000009
The PBM 2023 Grantor Retained Annuity Trust	1.5%	4,013,459	4,013,459	0	Paul B. Manning	Paul B. Manning, Trustee	0001234567
The PBM 2025 Grantor Retained Annuity Trust	1.5%	4,000,000	4,000,000	0	Paul B. Manning	Paul B. Manning, Trustee	0001234569
BKB Growth Investments, LLC	1.1%	2,841,704	0	2,841,704	/s/ Paul B. Manning and /s/ Bradford Manning	By: Tiger Lily Capital, LLC, its Manager, By: Paul B. Manning, Manager and Bradford Manning, Manager	0001234568
BKB G2 Investments, LLC	0%	22,000	0	22,000	/s/ Paul B. Manning and /s/ Bradford Manning	By: Tiger Lily Capital, LLC, its Manager, By: Paul B. Manning, Manager and Bradford Manning, Manager	0001234570