BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 per share (BCYC) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2019 to Q4 2025

Type / Class
Equity / American Depositary Shares, each representing one ordinary share, nominal value 0.01 per share
Symbol
BCYC on Nasdaq
Shares outstanding
49,938,272
Price per share
$6.58
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
38,999,546
Total reported value
$276,432,349
% of total 13F portfolios
0%
Share change
+532,216
Value change
+$3,442,632
Number of holders
107
Price from insider filings
$6.58
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 per share (BCYC) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Forbion Growth Opportunities Fund II Cooperatief U.A. 7.3% $28,343,629 3,452,330 Forbion Growth Opportunities Fund II Cooperatief U.A. 21 Nov 2024
ARMISTICE CAPITAL, LLC 6.5% +15% $21,292,880 +$3,711,120 3,236,000 +21% Armistice Capital, LLC 31 Dec 2025
WESTFIELD CAPITAL MANAGEMENT CO LP 6% +11% $20,720,099 +$2,787,083 3,016,026 +16% Westfield Capital Management Company, L.P. 31 Dec 2025
Point72 Asset Management, L.P. 3.9% -49% $14,882,536 -$15,032,008 1,860,317 -50% Point72 Asset Management, L.P. 30 Jun 2025
Deep Track Capital, LP 2.4% -54% $9,625,952 -$12,943,416 1,203,244 -57% Deep Track Capital, LP 30 Jun 2025

As of 31 Dec 2025, 107 institutional investors reported holding 38,999,546 shares of BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 per share (BCYC). This represents 78% of the company’s total 49,938,272 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 per share (BCYC) together control 72% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
BAKER BROS. ADVISORS LP 22% 10,885,357 0% 0.45% $77,068,328
FCPM III SERVICES B.V. 6.9% 3,468,430 +0.47% 3.2% $24,556,484
ARMISTICE CAPITAL, LLC 6.5% 3,236,000 +8.7% 0.56% $22,910,880
WESTFIELD CAPITAL MANAGEMENT CO LP 6% 3,016,026 +2.2% 0.09% $21,353,464
Siren, L.L.C. 4% 2,012,752 0% 0.43% $14,250,284
ACADIAN ASSET MANAGEMENT LLC 3.3% 1,671,258 +27% 0.02% $11,806,000
Long Focus Capital Management, LLC 3.3% 1,633,091 +15% 0.59% $11,562,284
GSK plc 3.1% 1,529,561 0% 1.4% $10,829,292
Candriam S.C.A. 2.4% 1,192,279 +1.7% 0.04% $8,441,695
PRICE T ROWE ASSOCIATES INC /MD/ 2.3% 1,171,787 -15% 0% $8,297,000
PRINCIPAL FINANCIAL GROUP INC 2.3% 1,148,272 -0.01% 0% $8,129,766
SCHRODER INVESTMENT MANAGEMENT GROUP 1.2% 584,770 0% $3,976,436
BNP PARIBAS ASSET MANAGEMENT Holding S.A. 1.1% 568,225 0% $4,023,000
RENAISSANCE TECHNOLOGIES LLC 1.1% 566,600 +9.2% 0.01% $4,011,528
SILVERCREST ASSET MANAGEMENT GROUP LLC 0.96% 476,976 0% 0.02% $3,376,990
MORGAN STANLEY 0.93% 465,222 -43% 0% $3,293,773
Birchview Capital, LP 0.93% 462,700 +200% 1.9% $3,275,916
BlackRock, Inc. 0.67% 332,889 +18% 0% $2,356,854
MILLENNIUM MANAGEMENT LLC 0.65% 326,626 -69% 0% $2,312,512
Jefferies Financial Group Inc. 0.6% 297,247 -26% 0.02% $2,104,509
MOORE CAPITAL MANAGEMENT, LP 0.55% 275,000 +120% 0.04% $1,947,000
CITADEL ADVISORS LLC 0.54% 271,383 +44% 0% $1,921,391
Palo Alto Investors LP 0.44% 221,071 0% 0.22% $1,565,183
PINNACLE ASSOCIATES LTD 0.38% 190,480 -3.1% 0.02% $1,348,598
PLATINUM INVESTMENT MANAGEMENT LTD 0.37% 184,603 0% 0.3% $1,306,989

Institutional Holders of BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 per share (BCYC) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 38,999,546 $276,432,349 +$3,442,632 $7.08 107
2025 Q3 36,906,185 $285,619,779 -$29,768,237 $7.74 99
2025 Q2 41,200,406 $286,338,478 -$7,404,258 $6.95 110
2025 Q1 41,735,285 $354,350,748 -$8,366,393 $8.49 95
2024 Q4 41,890,221 $586,472,317 -$21,543,705 $14.00 96
2024 Q3 40,439,351 $915,266,321 +$21,080,974 $22.63 104
2024 Q2 39,722,044 $803,959,492 +$167,237,644 $20.24 105
2024 Q1 30,475,266 $758,677,656 +$6,974,793 $24.90 93
2023 Q4 31,374,408 $567,252,558 -$28,664,876 $18.08 98
2023 Q3 32,418,922 $651,281,538 +$165,201,151 $20.09 101
2023 Q2 24,236,173 $618,449,426 +$18,484,148 $25.52 84
2023 Q1 23,558,818 $498,895,905 -$47,151,037 $21.27 89
2022 Q4 23,577,228 $697,847,861 +$39,624,167 $29.60 87
2022 Q3 23,196,999 $539,598,338 +$13,911,506 $23.26 77
2022 Q2 22,709,672 $381,075,755 -$69,885,312 $16.78 78
2022 Q1 20,168,148 $884,247,452 -$137,175,184 $43.88 100
2021 Q4 21,550,279 $1,311,636,981 +$387,558,387 $60.87 98
2021 Q3 14,210,499 $591,072,741 +$80,484,868 $41.59 67
2021 Q2 12,412,613 $376,901,461 +$30,169,498 $30.36 53
2021 Q1 11,420,830 $341,203,000 +$123,064,104 $29.87 39
2020 Q4 7,328,435 $131,544,000 -$3,975,466 $17.95 27
2020 Q3 7,550,163 $143,830,000 +$24,085,212 $19.05 18
2020 Q2 6,287,737 $98,861,000 +$4,298,929 $15.74 15
2020 Q1 5,977,254 $81,901,000 +$1,078,206 $13.65 12
2019 Q4 5,901,993 $55,657,000 -$6,870,216 $9.43 8
2019 Q3 6,446,149 $73,420,000 -$1,907,302 $11.39 11
2019 Q2 6,635,216 $66,751,000 +$66,751,000 $10.06 14