BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 euro per share (BCYC)

Q: What does CUSIP 088786108 represent in this 13F holders report?

CUSIP 088786108 is the security identifier for BCYC - BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 euro per share used to aggregate holder disclosures.

Q: How many institutions held BCYC - BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 euro per share in Q4 2025?

109 institutional investors reported BCYC - BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 euro per share for Q4 2025. Use the holders table for investor-level position and value details.

CUSIP: 088786108

Q4 2025 13F Holders as of 31 Dec 2025

Security type / class: Equity / American Depositary Shares, each representing one ordinary share, nominal value 0.01 euro per share
Total 13F shares: 39,173,346
Total 13F value: $277,662,853
Share change: +532,216
Put/Call ratio: 37%
SEC-reported price per share: $7.08
Number of holders: 109
Value change: +$3,442,632
Number of buys: 52
Number of sells: 40
Shares outstanding: 50,340,741

Security key

088786108

Report period

Q4 2025

Institutions

109

Top holders

BCYC full security history Ownership snapshot Full 13F holder table BICYCLE THERAPEUTICS PLC SEC filings BICYCLE THERAPEUTICS PLC company facts

Broader feeds

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Ownership snapshot

Top reported holders of BCYC - BICYCLE THERAPEUTICS PLC - American Depositary Shares, each representing one ordinary share, nominal value 0.01 euro per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

Forbion Growth Opportunit...

Disclosed value leader

BAKER BROS. ADVISORS LP

Comparable rows

15/15

Latest evidence

30 Sep 2025

13D/G 13F Lead comparable stake: 7.3% 13D/G row: Forbion Growth Opportunities Fund II Cooperatief U.A. Showing 1-6 of 15 holder rows.

Quick read

Forbion Growth Opportunities Fund II Cooperatief U.A. leads the comparable SEC ownership view at 7.3%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens Forbion Growth Opportunities Fund II Cooperatief U.A.'s linked filing trail.

Comparable ownership Top 5

Forbion Growth Opportunities Fund... 7.3%

Point72 Asset Management, L.P. 3.9%

Deep Track Capital, LP 2.4%

BAKER BROS. ADVISORS LP 22%

FCPM III SERVICES B.V. 6.9%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Forbion Growth Opportunities Fund II Cooperatief U.A.	13D/G 13D/G	7.3%	$28,343,629 3,452,330 shares	$0	21 Nov 2024
Point72 Asset Management, L.P.	13D/G 13F Company 13D/G 13F	3.9%	$14,882,536 1,860,317 shares	-$15,032,008	30 Jun 2025
Deep Track Capital, LP	13D/G 13D/G	2.4%	$9,625,952 1,203,244 shares	-$12,943,416	30 Jun 2025
BAKER BROS. ADVISORS LP	13F Company 13F	22%	$84,252,663 10,885,357 shares	—	30 Sep 2025
FCPM III SERVICES B.V.	13F Company 13F	6.9%	$26,721,034 3,452,330 shares	—	30 Sep 2025
ARMISTICE CAPITAL, LLC	13F Company 13F	5.9%	$23,049,720 2,978,000 shares	—	30 Sep 2025

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2025

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

109

39,173,346

Rows available

109

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q4 2025 vs Q3 2025 Across Filers

Q3 2025 holders

Q4 2025 holders

109

Holder diff

Investor	Q3 2025 Shares	Q4 2025 Shares	Share Diff	Share Chg %	Q3 2025 value	Q4 2025 value	Value change	Value Chg %